Graeme Clark Collection
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ItemThe pitch of amplitude-modulated electrical stimuli in cochlear implantees [Abstract]( 1993)The ability of cochlear implantees to detect amplitude modulation of pulsatile electrical stimulation, suggests that some speech feature information may be conveyed effectively by this means. For example, modulations at the fundamental frequency of speech may provide a voice pitch percept to implantees, particularly in speech processing strategies which generate constant-rate stimulation. The pitch evoked by sinusoidally modulated current pulse trains on a single electrodes has been studied. Modulation frequencies of 100, 150 and 200Hz, and carrier pulse rates varying from 200 to 1200Hz, were used. The results showed that the pitch of the stimulation was related to the modulation frequency, provided that either the carrier rate was a multiple of the modulation frequency, or the carrier rate was sufficiently high (at least four times the modulation frequency for the stimuli studied here). Furthermore, when the modulated stimuli were matched in pitch to non-modulated pulse trains, it was. found that the rate of the matched non-modulated stimuli was close to but somewhat higher than the modulation frequency. This difference depended on the carrier rate and varied among subjects.
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ItemEvaluation of leadwire fixation for paediatric cochlear implants [Abstract]( 1994)A paediatric cochlear implant should include a leadwire system that can readily expand in the presence of tissue adhesions and can be effectively fixed at a site close to the cochlea to ensure that the electrode array is not displaced during skull growth. In this study, leadwires were implanted in six young animals for a period of five months. During explantation, the mean force � standard deviation required to expand individual leadwire was found to be 12.5 � 5.0g. In order to evaluate the efficacy of leadwire fixation techniques, four fixation procedures were initially developed in human temporal bones and subsequently used to fix leadwires implanted in the temporal bones of eight animals for a period of four months. Leadwires were fixed by platinum wires at the fossa incudis or by platinum wires with a titanium barbed nail at the mastoid. The biomechanical evaluation revealed that the forces required to displace the leadwire from fixation points were 70.6 � 33.5g. Significantly, the forces required to withdraw a chronically implanted electrode array from an animal cochlea were 1.5 � 0.4g. The present results highlight the importance of an effective leadwire fixation technique for paediatric cochlear implants, particularly in preventing the displacement of an electrode array from the cochlea during skull growth.
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ItemEffects of rate and pulse manipulations of the spectral maxima speech processor upon speech production( 1993)Postlingually deafened adults experience many changes in their speech as a consequence of late-onset deafness. Previous studies have indicated changes in fundamental frequency, duration, intensity, and vowel formant frequencies in postlingually deafened adults. Postlingually deafened adults who receive multichannel cochlear implants demonstrate improved control of fundamental frequency and intensity. Shifts in formant frequencies to values similar to normal hearing. speakers also appears in some adult implant users. In order to examine how adult implant users adjust their vowel production in response to map changes, we examined vowel production following manipulations to the processing strategy of the Spectral Maxima Speech Processor. This processor uses a speech processing scheme in which six spectral maxima from the outputss of 16 bandpass filters stimulate the cochlea on a place basis at a constant rate. The rate of sampling of the filterbank output is 250 Hz, so six biphasic pulses are presented every 4 msec and there is no attempt to extract fundamental frequency or to find the formant peaks in the speech signal. Two manipulations to the scheme were examined. In the first condition, the rate of sampling remained at 250Hz but eight biphasic pulses were presented rather than six. In the second condition, six biphasic pulses were presented but the rate of sampling of the filterbank output was increased to 400 Hz. Speech samples also were acquired using the standard spectral maxima processor .and with no auditory feedback when the processor was turned off. Speech samples from three �subjects were acquired immediately after receiving the manipulated speech processors and after two weeks experience with the various processors. Preliminary data indicate one subject experienced increased fundamental frequencies while using the 400 Hz high rate strategy. No significant changes were observed in fundamental frequency between the normal SMSP processor and the eight pulse variation. Elimination of feedback resulted in significantly lower fundamental frequencies. The high rate and eight pulse variations resulted in significantly higher first formant frequencies. Second formant frequencies also appear to be influenced by the processing strategies. Comparisons of values produced immediately after receiving a new strategy versus those produced after two weeks use show shifts in primarily first formant values. Data will be presented for all three subjects and discussed in regard to sensitivity to variations in speech processing schemes and the influence of experience with manipulated schemes. (Work supported by the N1H-NIDCD).
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ItemElectrical stimulation of the auditory nerve: comparison of half-band with full-band scala tympani bipolar electrodes( 1993)The Melbourne/Cochlear auditory prosthesis uses an intracochlear electrode array containing 22 circumferential full-band electrodes mounted on a Silastic carrier. It could be hypothesized that half-band electrodes, oriented towards the modiolus, would produce lower stimulus thresholds than conventional full-band electrodes. This hypothesis is based on the assumption that, compared with full-band electrodes, half-band electrodes would produce an electrical field in which a greater proportion of the current would excite a defined group of neurons. In order to verify this hypothesis we recorded electrically evoked auditory brainstem responses (EABRs) for both full- and half-band electrodes inserted in the scala tympani of deafened cats. EABR thresholds for half-band electrodes oriented towards the modiolus were not significantly different from thresholds evoked using full-band electrodes (p>0.05, paired t-test), whereas thresholds evoked using half-band electrodes oriented towards the outer scala wall were significantly higher (p<0.01) than either the modiolar half-band or the full-band electrodes. These physiological results suggest that the electrical field generated within the auditory nerve by modiolar oriented half-band electrodes does not differ significantly from that produced by full-band electrodes. On the basis of these results, together with the fact that half-band electrodes would have higher current densities and electrode impedances, and would require careful orientation during implantation, we consider that there is no benefit in incorporating half-band electrodes in the design of scala tympani electrode arrays.
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ItemComparative performance of children using the cochlear 22-channel implant and 8-channel 'Tickle Talker'( 1992)Direct comparison of "Tickle Talker" and Cochlear Implant users is problematic, due to difficulties in matching groups of children for hearing loss, age, duration of deafness, speech perception and language skills, and educational placement. However, two studies were undertaken to compare and contrast potential benefits available from these two devices. In the first study, a number of children from one educational setting were evaluated over a six month period. Half of the children used the multiple channel cochlear implant, while the other half used the multiple channel "Tickle Talker". The number of training sessions, clinicians involved, type of training provided, and overall management philosophy were identical for both devices. Comparison of progress of these two groups of children demonstrates that both devices are effective in improving' communication. However, differences were found with the tactile device being more limited in information provided and speech perception benefits. In the second study, two children who have used both devices were evaluated. These two children initially used the ''Tickle Talker" for periods up to two years, and subsequently had a multiple-channel cochlear implant. Similar habilitation was provided to these children with both devices, and measures of speech perception were taken at similar time periods. Results for one of the children, a prelinguistically deafened adolescent, already show similar benefits in terms of supplementation of lipreading for both devices. However, this patient has also shown some open-set word and sentence perception using the implant-alone. To date, this level of performance has not been achieved with the ''Tickle Talker". The results of these studies suggest a role for a multiple channel tactile device in a cochlear implant clinic as a training device for evaluating the ability of adults or children to integrate speech information presented through different sensory modalities. This could facilitate pre-implant evaluation of the potential for children to benefit from added speech information, which is often difficult to evaluate in congenitally deaf children.
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ItemSteady-state evoked potentials (SSEPS): a new tool for the accurate assessment of hearing in cochlear implant candidates [Abstract]( 1992)Determining hearing thresholds is crucial in assessing cochlear implant candidates; never more so than in young children unable to undergo behavioural audiometry. In these children an objective measure of hearing is desirable. Steady-state evoked potentials (SSEPs) are potentials recorded from the scalp and simultaneously analysed. Stimuli ore amplitude and frequency modulated pure tones. A system has been developed which allows the presence of such a response to be automatically detected and the technique thus permits an objective, frequent specific assessment of hearing threshold to be mode in sleeping or awake subjects (1). This paper investigates the use of SSEPs in determining hearing thresholds in young profoundly deaf children who are candidates for cochlear implants. Responses in such patients are compared with those obtained in normal adults, neonates and experimental animals. Results indicate that the SSE? can provide a consistent and reliable measure of threshold and the technique appears to have a number of advantages over the auditory brainstem response: automated response detection removes the subjective element of threshold determination, higher levels of stimulus presentation are possible, low frequency threshold determination is more accurate and the testing procedure IS quicker.
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Item3D reconstruction of the temporal bone in cochlear implant surgery [Abstract]( 1991)High resolution CT-imaging is a routine part of the preoperative evaluation of prospective cochlear implant patients. We have used image analysis techniques to produce three-dimensional (3D) reconstruction of the temporal bone from serial CT-scans. These images have proved very useful in the examination of the temporal bone prior to implant surgery.
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ItemMultichannel cochlear implants in children: an overview of experimental and clinical results [Abstract]( 1991)During the last decade there has been great progress in the clinical management of profound, postlinguistically deafened adults through the use of multichannel cochlear implants. The device developed by Cochlear Pty. Ltd. in association with the University of Melbourne, electrically stimulates selective regions of the residual auditory nerve using an array of 22 Pt electrodes located within the scala tympani. A speech processing strategy has been developed to provide patients with both voice pitch, and first and second formant information. Following experimental safety studies and successful clinical trials, this device was approved for use in adults by the United States FDA in 1985. In 1990, following further miniaturization of the implant, the FDA approved the device for use in profoundly deafened children above the age of two years. The present paper presents an overview of our recent biological safety studies and clinical experience with cochlear implants in children, and discusses the likely future development of these devices. Our biological safety studies were designed to evaluate the safety and design requirements of cochlear implantation in children, and more recently has focussed on issues for implantation in very young children (< 2 years old). These studies included the measurement of growth in the human temporal bone and the development of lead wires that can accommodate such growth, the development of an electrode fixation technique close to the cochlea, the effect of cochlear implantation on skull growth, the effect of long-term electrical stimulation on the maturing auditory system and the stimulating electrodes, and the effect of middle ear infection on cochlear implantation. Our clinical experience is based on twenty-five children that have now been implanted in our clinic. They include (i) postlinguistically deafened children; (ii) congenitally or early-deafened young children; and (iii) congenitally or early deafened adolescents. Clinical testing has shown improvements in speech perception, speech production and language in all three groups. Postlinguistically deafened children show similar speech perception results to postlinguistically deafened adults. For the congenitally deaf, younger children tend to show better results than the adolescents. Significantly, these clinical results are consistent with results from 142 children obtained from clinics throughout the world. These experimental and clinical results support the use of cochlear implants in young children. Further clinical improvements can be expected in the future with advances in both hardware and speech processing strategies.
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ItemCochlear implant safety studies [Abstract]( 1991)We have examined a number of safety issues associated with cochlear implantation in both adults and children and confirm that it is safe. The results of these studies may be summarized as follows: 1) The insertion of a free-fit scala tympani array into the human cochlea produces minimal damage to cochlear structures provided insertion is stopped at the point of first resistance. 2) Chronic intracochlear implantation and electrical stimulation using charge balanced biphasic current pulses does not result in neural degeneration or evoke an adverse tissue reaction within the cochlea. 3) The use of fascia to seal the implanted round window results in an effective barrier to the spread of infection into the cochlea. 4) Temporal bone studies have shown that the distance between the round window and the fossa incudis remains essentially unchanged from birth. Therefore, the fossa incudis provides a suitable fixation point for the electrode array in young children. This study also showed that the distance from the round window to the implanted receiver-stimulator undergoes significant change in children of up to two years of age. These children would require an expanding leadwire system. 5) Finally, long-term effects of cochlear implant surgery on skull growth have shown that this should not be a problem when implanting very young children. This work was supported by the NIH (NOI-NS-7-2342).
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ItemClinical results for profoundly deaf patients using the 22-elctrode cochlear prosthesis [Abstract]( 1987)The 22-electrode cochlear prosthesis developed in Australia by the University of Melbourne and Cochlear Pty. Limited has been in clinical use in Melbourne for five years. Results for 40 postlingually deaf adults have shown significant communication benefit for 90% of patients. Twenty patients (50%) have demonstrated the ability to understand conversational speech without lipreading or visual cues. No electronic or mechanical failures have been observed in any of the implanted devices. There have been no serious medical complications, but psychological disturbance has occurred in two cases. Experience with prelingually deaf adults has indicated that initial hearing responses for this group are not as good as for the postlingually deaf patients. However, improvement over time has been evident with consistent use of the device. Long-term benefit for these patients will depend to a large extent on motivational and social factors. Results for a small number of young deaf children have been encouraging. The age at onset of profound deafness, intelligence, educational management and family support are all important factors affecting the potential benefit of a cochlear implant for a child.