Graeme Clark Collection
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ItemSpatial representation of the cochlea within the inferior colliculus of neonatally deafened kittens following chronic electrical stimulation of the auditory nerve [Abstract]( 1995)The orderly tonotopic representation of the cochlea is accurately reproduced within the central auditory system of normal hearing animals. Any degradation of this representation as a result of a neonatal hearing loss or chronic electrical stimulation during development could have important implications for the use of multichannel cochlear implants in young children. In the present study we have used 2-deoxyglucose autoradiography (2-00) to examine the topographic representation of the cochlea within the inferior colliculus (IC) of neonatally deafened kittens following periods of chronic intracochlear electrical stimulation.
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ItemDecrement in auditory nerve function following acute high rate stimulation in guinea pigs [Abstract]( 1995)Cochlear implants have been shown to successfully provide profoundly deaf patients with auditory cues for speech discrimination. Psychophysical studies suggested that speech processing strategies based on stimulus rates of up to 1000 pulses per second (pps) may lead to an improvement in speech perception, due to a better representation of the rapid variations in the amplitude of speech. However, "neural fatigue" has been known to occur following brief periods of electrical stimulation at rates high enough to ensure that stimuli occur within the neurons relative refractory period, and has been shown to depend on stimulus duration and rate of the evoked neural activity. Prolonged electrical stimulation at these high stimulus rates could, therefore, have an adverse effect on the neurons metabolism and result in cellular energy depletion.
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ItemThe auditory cortex and auditory deprivation: experience with cochlear implants in the congenitally deaf [Abstract]( 1995)The primary auditory cortex (AI) exhibits a topographic representation of the organ of Corti in normal hearing animals. Plasticity studies have shown that this orderly representation of frequency can be modified following a restricted hearing loss or by behavioural trainingl,2. Little is known, however, of the effects of a profound hearing loss on AI, although a number of early studies have suggested an enhancement of activity from other modalities3. Knowledge of the functional status of the central auditory pathway in the profoundly deaf, and the ability of these structures to undergo reorganization particularly following long periods of auditory deprivation - are important issues for the clinical management of cochlear implant patients. In this paper we review our recent clinical and experimental experience with cochlear implants in the congenitally deaf.
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ItemResults of multichannel cochlear implantation in very young children [Abstract]( 1995)Most researchers and clinicians working in the cochlear implant field have assumed that profoundly deaf children will have a better prognosis in terms of speech perception, speech production and language development, implanted at as young an age as possible. However, it has been difficult to gather direct evidence for this hypothesis due to the problems in assessing children under the age of five years with formal tests.
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ItemSpeech perception benefits for children using the Speak speech processing strategy in quiet and noise [Abstract]( 1995)The Speak speech processing strategy, based on the Spectral Maxima Speech Processor (SMSP) developed at the University of Melbourne, has now been implemented in the Spectra 22 speech processor developed by Cochlear Pty Limited, and clinical trials of both patients changing from the previous Multipeak strategy to Speak and patients starting up with Speak have been conducted. Results in adult patients changing to Speak have shown significant improvements in speech perception in quiet and particularly in background noise as compared with Multipeak.
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ItemSpeech perception benefits for implanted children with preoperative residual hearing [Abstract]( 1995)Since the implantation of the first children with the Nucleus 22-channel cochlear prosthesis in Melbourne in 1985, there has been rapid expansion in the number of implanted children world-wide. Improved surgical technique and experience in paediatric assessment and management have contributed to a trend to implant very young children. At the same time there has also been continuing development of improved speech processing strategies resulting in greater speech perception benefits.
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ItemSpeech perception benefits for implanted children with preoperative residual hearing [Abstract]( 1995)Since the implantation of the first children with the Nucleus 22-channel cochlear prosthesis in Melbourne in 1985, there has been rapid expansion in the number of implanted children world-wide. Improved surgical technique and experience in paediatric assessment and management have contributed to a trend to implant very young children. At the same time there has also been continuing development of improved speech processing strategies resulting in greater speech perception benefits. In the Melbourne program, over 60% of children obtain significant scores on open-set word and sentence tests using their cochlear implant alone without the aid of lipreading. As parents and professionals have become aware of these improved benefits to speech perception benefits in profoundly deaf children, there have been requests to consider implanting severely-to-profoundly deaf children. In these children with higher levels of residual hearing, only those children with poorer-than-expected performance on speech perception tests using hearing aids have been considered for surgery. A number of such cases have now been implanted in the Melbourne program. The speech perception benefits for this group are reported and are being compared with benefits for the profoundly deaf group of children.
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ItemSpeech perception benefits for children using the Speak speech processing strategy in quiet and noise [Abstract]( 1995)The Speak speech processing strategy, based on the Spectral Maxima Speech Processor (SMSP) developed at the University of Melbourne, has now been implemented in the Spectra 22 speech processor developed by Cochlear Pty Limited, and clinical trials of both patients changing from the previous Multipeak strategy to Speak and patients starting up with. Speak have been conducted. Results in adult patients changing to Speak have shown significant improvements in speech perception in quiet and particularly in background noise as compared with Multipeak. Preliminary studies with children changing from Multipeak to Speak strategy, measured over a 10 month period, have also shown significant benefits from use of the Speak scheme in both quiet and noisy test situations. Results of follow up studies of these children after more than one year experience with the Speak processing strategy are presented. Statistical analysis of performance over time suggests that an increase in benefit is observed in children after additional experience with the Speak processing strategy. In addition, results for children who have used only the Speak processing strategy from the time of implantation are also presented. The results confirm that the Speak processing strategy provides significant benefits in quiet, and particularly in the presence of background noise for both groups of patients.
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ItemResults of multichannel cochlear implantation in very young children [Abstract]( 1995)Most researchers and clinicians working in the cochlear implant field have assumed that profoundly deaf children will have a better prognosis in terms of speech perception, speech production and language development. if implanted at as young an age as possible. However, it has been difficult to gather direct evidence for this hypothesis due to the problems in assessing children under the age of five years with formal tests. Recent results with older children have supported the view that early implantation may provide the optimal outcome in most cases. The implantation of very young children raises two areas of concern that do not apply in adults and older children: accurate assessment of degree of hearing loss and auditory potential; and postoperative assessment of outcomes. This paper will describe research results from the University of Melbourne which address these issues and present results for children implanted as young as eighteen months of age.
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ItemEvoked responses in the auditory cortex of the congenitally deaf white cat following electrical stimulation of the cochlea [Abstract]( 1995)Knowledge of the functional status of central auditory structures is important when estimating possible benefits of cochlear implantation in the congenitally deaf. Thus far the performance of prelingually deaf adults following cochlear implantation has been disappointing. We have used congenitally deaf cats as a model for prelingual deafness. These animals are deaf from an early age as shown by longitudinal recordings of auditory brainstem responses. They were studied as adults (age 2 years). Under general anaesthesia the cochleae were electrically stimulated using the NUCLEUS-22 banded scala tympani electrode array. Recordings were made from the contralateral auditory cortex and inferior colliculus. Gross potentials, together with multi� and single-unit activities were recorded. Here we confine ourselves to gross potential recordings from the auditory cortex. The skull was opened over the auditory area and the cortex photographed. A computer-controlled 3-axes microdrive provided precise and reproducible positioning of the monopolar recording electrode. Gross potentials were evoked by electrical stimulation of the auditory nerve using bipolar electrodes 1/2, 7/8 or 1/8 (electrode 1 being the most apical). These potentials were recorded from both the cortical surface and at depths of up to 4 mm, amplified and band pass filtered (10 Hz to 10 kHz). The stimuli (0.2 ms biphasic pulses) evoked middle latency responses (10 - 20 ms) over the primary and secondary auditory areas. Thresholds were lowest using electrodes 1/8 (-24 dB re. 1 mApp). Narrower electrode configurations (1/2 and 7/8) were up to 15 dB less effective. The potentials evoked were mono-, bi- or triphasic in shape, depending on recording site. We observed little evidence of tonotopic cortical mapping of stimulation site (1/2 vs. 7/8). If present at all, potentials were considerably smaller when the recording electrode was placed outside the auditory areas. Moreover, threshold currents were far higher (40 dB). It is concluded that the auditory cortex of congenitally deaf animals receives specific information via stimulation of the auditory nerve.