- Graeme Clark Collection
Graeme Clark Collection
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ItemThe effect of pulsatile intracochlear electrical stimulation on intracellularly recorded cochlear nucleus neuronsPaolini, Antonio, G. ; Clark, Graeme M. (Monduzzi Editore, 1997)The anterior division of the ventral cochlear nucleus (AVCN) is the first relay station of the auditory pathway. We examined responses of neurons in the A VCN to intracochlear electrical stimulation using in vivo intracellular recordings. Twin pulse stimulation results indicated that these neurones evoke action potentials which are able to follow pulsatile stimulation at high rates. This ability to respond to each pulse along the stimulus train diminished when stimulus duration was increased to 50 ms. At rates 400 Hz and below in all neurones tested a deterministic response was seen to this longer duration pulsatile stimulation. With increasing rate of stimulation the response become more stochastic with apparent loss of encoding ability. These results have in1pIications in the clinical application of cochlear implants operating at high stimulus rates.
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ItemTemporal coding in auditory neurons to electrical stimulationHocking, J. ; Brown, M. ; Clark, Graeme M. (Monduzzi Editore, 1997)Different electrically evoked response properties are elicited by similar acoustically differentiated AVCN units. Discharge entrainment and synchrony of some AVCN units is maintained throughout the electrical stimulus duration at all rates, similar to that described for auditory nerve fibres. Other units exhibit a decline in discharge entrainment over the duration of the electrical stimulus with increasing rate. Within this group of units, some exhibit a highly synchronous response while others show a decline in the response synchrony with increasing stimulus rate.