Graeme Clark Collection

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Start date: 1994 × Type: Journal Article × Subject: hearing loss ×

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    Formant-based processing for hearing aids
    Blamey, P. J. ; Dooley, G. J. ; Seligman, P. M. ; Alcantara, J. I. ; Gerin, E. S. ( 1994)
    A body-worn hearing aid has been developed with the ability to estimate formant frequencies and amplitudes in real time. These parameters can be used to enhance the output signal by "sharpening" the formant peaks, by "mapping" the amplitudes of the formants onto the available dynamic range of hearing at each frequency, or by resynthesizing a speech signal that is suited to the listener�s hearing characteristics. Initial evaluations have indicated small improvements in speech perception for three groups of subjects: users of a combined cochlear implant and speech processing hearing aid, normally hearing listeners in background noise, and a hearing aid user with a severe hearing loss.
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    Partial hearing loss in the macaque following the co-administration of kanamycin and ethacrynic acid
    Shepherd, R. K. ; Xu, S. A. ; Clark, Graeme M. ( 1994)
    Co-administration of kanamycin (KA) with the loop diuretic ethacrynic acid (EA) rapidly produces a profound hearing loss in the cat while maintaining normal renal function [Xu et al., Hear. Res. 70, 205-215 (1993)]. In the present paper we have applied this deafening procedure to the old world monkey Macaca fascicularis (macaque). Following the co-administration of KA and EA, the hearing loss in the macaque developed far slower than we observed in the cat. Moreover, unlike the cat, there was evidence of a partial recovery in the animal’s hearing, resulting in a bilaterally symmetrical high frequency hearing loss. The extent of this hearing loss was dependent on the dose of the EA administered. Finally, the most unexpected result of the present study was the degree of acute nephrotoxicity experienced by these animals following the drug administration. The sensitivity of this species to renal failure restricted the dose of EA that could be safely administered. In conclusion, the co-administration of KA and EA cannot reliably produce a profound hearing loss in the macaque. While it can produce a dose dependent high frequency hearing loss the animal will also experience acute renal failure that requires careful management.