Graeme Clark Collection
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ItemThe use of click-ABR and steady state evoked potentials for hearing assessment in young cochlear implant candidates [Abstract]( 1997)The accurate assessment of hearing thresholds in prospective cochlear implant candidates is essential. As the minimum age of implantation has reduced, audiologists have been faced with the complicated task of obtaining precise audiometric information in children whose immaturity may severely restrict the assessment process. Clearly for these young candidates, there is a place for a reliable, objective measure of residual hearing in the pre-operative test battery. This paper examines the degree of accuracy with which the click-ABR and the steady-state evoked potential (SSEP) techniques can provide estimates of hearing level in subjects with several profound hearing loss.
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ItemExpandable leadwires for a paediatric cochlear implant [Abstract]( 1993)Anatomic studies of skull growth have shown an increase (about 20 mm) in the distance between the round window and the asterion where the receiver-stimulator is usually located. In order to accommodate the skull growth of young patients, an expandable leadwire connecting the receiver-stimulator and the electrode array is necessary. Several expandable leadwires were evaluated in experimental animals, including helical leadwires protected by Silastic tubes and leadwires, with "V" or "W"-shaped levels in a single phase, and protected by thin Silastic or Teflon bags. The leadwires together with their controls were implanted on young animal's scapulae, temporal and parietal bones and in subcutaneous tissue. The in vivo expansion of the leadwire was monitored by periodic x-ray examination and the force to expand the leadwire was measured at the completion of implantation. The results showed that helical leadwires weresurrounded by fibrous tissue and a large force was required to expand them. The V or W-shaped leadwires were able to expand up to 20 mm in vivo and only a moderate force was required to expand them. For most of the cases, there was none or little fibrous tissue in Silastic or Teflon bags. The results indicated that for a paediatric cochlear implant, leadwires with V or W-shaped levels could, expand and biocompatible envelopes could effectively protect the leadwires from being bound by fibrous tissue.
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ItemPaediatric cochlear implant surgery [Abstract]( 1992)The operation in children is similar to that in adults, but special care needs to be taken with the skin flap, the anchoring of the electrode array and the sealing of .the cochleostomy. Research into the effects of head growth and otitis media in an implanted ear indicates that these should not be a problem. Surgical complications are also similar to those in adults, with the most common being related to the skin flap. The major complication rate at 4 % is slightly less than that in adults and most of these get effective implant function.
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ItemPaediatric cochlear implantation: radiological and histopathological studies of skull growth in the monkey( 1993)The human skull undergoes significant growth within the first two years of life (Dahm et aI, 1992). Therefore, before children under two can be considered candidates for cochlear implantation, the effects of the surgical procedure on subsequent skull growth must be well understood. To evaluate the effects of implantation on skull growth four macaque monkeys were implanted with dummy cochlear implants at six months of age. To model the procedure in the very young child, the bed for the receiver-stimulator was drilled across a calvarial suture down to the underlying dura and an electrode array inserted into the scala tympani via a mastoidectomy and posterior,tympanotomy. Plain skull radiographs were perioqical1y taken to monitor skull growth for periods of up to three years following implantation. Their longitudinal measurements revealed no evidence of asymmetrical skull growth when compared with unimplanted control animals. Computer tomographic scans taken at post-mortem confirmed these findings. Finally, subsequent histopathological evaluation of the receiver-stimulator package bed indicated that it becomes obliterated by hard tissue, resulting in a localized flattening of the vault under the receiver-stimulator. However, this tissue exhibited histological evidence of sutures, indicating that the surgical procedure should not lead to premature sutural closure. In conclusion, the present experimental results suggest that long-term cochlear implantation in very young children will not lead to any significant skull deformity.
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ItemThe effect of inflammation on blood vessel area as a cause of variation in ganglion cell density measurements in the cat cochlea [Abstract]( 1992)The success of a cochlear implant depends on an adequate number of surviving spiral ganglion cells. Further loss of ganglion cells may arise from the biology of cochlear implantation itself. The quantitative analysis of ganglion cells is, therefore, an important consideration when assessing the biological safety of a cochlear implant.
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ItemSpeech perception benefits for children using the 22-channel Melbourne/cochlear hearing prosthesis [Abstract]( 1993)In 1985; the first child was implanted with the Cochlear 22-channel cochlear prosthesis at the University of Melbourne Royal Victorian Eye & Ear Hospital Cochlear Implant Clinic. There are now 42 children who have received the device in Melbourne. Analysis of patient details for these children show a very heterogeneous group, with a wide range in age, hearing thresholds, duration of deafness and aetiology. The major aetiologies found were either a congenital profound deafness.; or a hearing loss due to meningitis. In all but 3 cases, the children are using 15 or more electrodes in the array. Speech perception benefits have been analyzed according to a six-level hierarchical classification scheme. All of-the children achieved a minimum benefit of discrimination of suprasegmental information (Category 2), and 59% of the children achieved open-set understanding of unfamiliar speech material without the aid of lip-reading (Categories 5 & 6). Detailed analysis suggests that the majority of children achieving open-set speech perception benefits had more than one year of experience with their implant. and less than seven years of profound deafness prior to implantation.
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ItemFactors associated with open-set speech perception in children using the Cochlear multiple-channel prosthesis [Abstract]( 1993)Since 1985, nearly 100 children have received the 22-channel cochlear prosthesis from the Melbourne and Sydney cochlear implant clinics. These two clinics account for the bulk of casesin Australia, and have similar management philosophies and selection criteria. The patient population represents a variety of etiologies, and ranges in age from 2 - 18 years of age. Bothcongenital and postlinguistic hearing losses are included. In order to assess benefit to speech perception in such a diverse group, the children's results have been tabulated according to a six level hierarchical scale of speech perception achievement. The scale ranges from category I,detection of sound only, to category 6, which includes significant perception scores for open-setwords and sentences. Analysis of the results shows that the majority of the children are achieving open-set speech perception benefits, and that results continue to improve with additional experience with their devices. There are a number of contributing factors to these open-set speech� perception results which have impact both on selection issues and on habilitation with different age ranges �of patients.
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ItemMultichannel cochlear implants in children: an overview of experimental and clinical results at the University of Melbourne [Opening Lecture]( 1992)During the last decade there has been great progress in the clinical management of profound, postlinguistically deafened adults through the use of multichannel cochlear implants. The device developed by The University of Melbourne in association with Cochlear Pty Ltd, electrically stimulates selective regions of the auditory nerve using an array of 22 platinum (Pt) electrodes located in the scala tympani. Its development followed basic experimental studies and the development and evaluation of a prototype device in the 1970's. Following safety studies and a successful clinical trial, the Melbourne/Cochlear multichannel implant was approved for use in adults by the United States Food and Drug Administration (FDA) in 1985. More than 3000 patients throughout the world have since been implanted with this device, many being able to understand a significant amount of unfamiliar, connected speech without lipreading Following miniaturization of the implant, it became suitable for use with children. In 1990, after additional biological safety and clinical investigations, the FDA approved the use of the Melbourne/Cochlear multichannel implant for profoundly deaf children above the age of two years. And in 1991, the device received the medical device implantation approval certificate from the Japanese Government. The present paper presents an overview of our recent biological safety studies and clinical experience in children, and discusses the likely future development of these devices.
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ItemFuture developments in speech processing for multichannel cochlear implants in children [Abstract]( 1992)The average speech perception score for adult implant patients is now about 60% on an open-set sentence test without lipreading. This is higher than the scores obtained by many profound and severe-to-profoundly impaired hearing aid users. This suggests that some hearing aid users, particularly those who use a hearing aid in one ear only, could benefit from a cochlear implant. As neither the implant nor the hearing aid will provide perfect speech recognition it is to be expected that this group should obtain maximum benefit by using the hearing aid in one ear together with the implant in the other ear. However, experience with this group of patients has shown that many people find the use of two independent devices unacceptable. Furthermore, perceptual interaction of the acoustic and electrical signals makes it desirable to be able to control the two outputs in a more co-ordinated way than is possible with two independent devices. Consequently, a "bimodal" speech processor has been developed with both acoustic and electrical outputs controlled from the same speech processing unit. Feature coding aspects of the implant processing have been applied to the acoustic signal in such a way as to enhance speech perception with the hearing aid and improve compatibility with the implant. Initial testing with the bimodal aid shows promise to help severely-to-profoundly impaired individuals. The device has also been useful as a research tool to investigate the complex interactions of simultaneous acoustic and electrical stimulation. The Spectral Maxima Sound Processor (SMSP) has also been developed at the University of Melbourne for use with the Nucleus cochlear implant. Studies with adult subjects have shown improved perception of vowels, consonants, words and sentences in quiet and sentences in background noise with the SMSP as compared with the MSP(MULTIPEAK) which is currently supplied for use with this implant. Results for four subjects showed mean scores for open set sentences at a 10 dB signal-to-noise ratio of 78.7% for the SMSP and 50.0% for the MSP. Mean scores for the same group on open set monosyllabic words in quiet were 57.4% for SMSP and 39.9% for MSP. These results suggest that future improvements in speech perception will be possible for children using the Nucleus cochlear implant.
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ItemFactors affecting speech perceptual performance for children using the 22-electrode cochlear prosthesis [Abstract]( 1992)Speech perception results for all 40 children and adolescents implanted with the. Nucleus 22 electrode cochlear prosthesis in Melbourne (as of February 1, 1992) were used to categorize performance for each child into one of six hierarchical groups: 1: detection of speech including high frequencies 2: discrimination of suprasegmental features of speech in addition to 1,3: discrimination and recognition of .vowel sounds in addition to 1 and 2,.4: discrimination arid recognition of consonant sounds in addition to 1, 2 and 3,5: open set speech. recognition with scores less than 20% for unfamiliar material in addition to 1 to 4,6: open set speech recognition with scores greater than 20% for unfamiliar material in addition to 1 to 5, above.All children demonstrated discrimination of suprasegmentals (level 2) and 58% demonstrated some openset speech recognition (levels 5 and 6). The pattern of results suggested that children who can discriminate segmental features of speech tend to achieve open set speech perception after adequate experience with the prosthesis. The performance level, described above, was used as the dependent variable in a multiple regression analysis to assess the effect of various factors on speech perception performance. The duration of profound hearing impairment and the amount of experience with the prosthesis were shown to contribute significantly to the variance, in performance level. A weaker trend was evident (or recently implanted children which may suggest that those' in oral/aural educational settings progress more rapidly, in terms of speech perception, than those in total communication settings. Age at implantation, cause of deafness, hearing levels prior to implantation, and number of electrodes in use, did not contribute significantly. to the variance in speech perception performance for these children. The results showed that all children with less than seven years of profound hearing impairment and with over one year of experience with the prosthesis have achieved some open-set speech recognition. This is an encouraging result as the trend in clinical application of cochlear prostheses has been towards implanting younger children in recent years. If this sample of hearing-impaired children in Melbourne is representative of the general population, we may expect that most implanted young children will ,develop reasonable speech perception skills after adequate experience and training.