Graeme Clark Collection
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ItemPotential applications of a small and high surface area platinum electrode as an implanted impedance bio-sensor or recording electrode.( 2001)A small Platinum (Pt) electrode (geometric area: -0.43 mm2) was treated in an electrochemical etching process, to produce a highly porous columnar thin layer (-600 nm) on the surface of the electrode. The modified Pt electrode (Pt-p) showed similar electrical properties to a platinum-black electrode but with high mechanical integrity. Previous studies of chronic stimulation had also shown good biocompatibility and surface stability over several months implantation. This paper discusses the potential applications of the modified electrode as an implanted bio-sensor: (1) as a recording electrode compared to an untreated Pt electrode. (2) as a probe in detecting electrical characteristics of living biological material adjacent to the electrode in vivo, which may correlate to inflammation or trauma repair. Results of electrochemical impedance spectroscopy (BIS) revealed much lower electrode interface polarisation impedance, reduced overall electrode impedance, and a largely constant impedance above 100 Hz for the Pt-p electrode compared with untreated Pt electrodes. This provides a platform for recording biological events with low noise interference. Results of A.C. impedance spectroscopy of the high surface area electrode only reflect changes in the surrounding biological environment in the frequency range (1 kHz to 100kHz), interference from electrode polarisation impedance can be neglected. The results imply that the surface-modified electrode is a good candidate for application to implantable biosensors for detecting bio-electric events. The modification procedure and its high surface area concept could have application to a smart MEMS device or microelectrode.
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ItemFactors determining and limiting the impedance behaviour of implanted bio-electrodes.( 2001)Impedance-frequency characteristics of several types of bio-electrodes, platinum (Pt), modified Pt, iridium (Ir), and iridium oxides, are presented in this paper. The study aimed at investigating the effects of bio-electrode array design and biological environments on the impedance behavior. Electrochemical impedance spectra were measured in physiological saline, and additional data were obtained from in vivo animal studies using implanted electrodes. The frequency spectrum can be approximately divided into three regions, in which different factors are dominant. At 1 kHz to 100 kHz or higher, impedance is mainly determined by the electrode geometric area and biological materials adjacent to the electrode. The impedance of a micromachined thin, film connector track could contribute in this region. At the low frequency region of 1 Hz (or lower) to 100 Hz, electrode material, the electrode real surface area and electrode potential playa dominant role in the impedance. There is a mix of these factors in the middle frequency region, 100 Hz to 1 kHz. However, the boundaries of the three regions are not fixed, but rather shift depending on the individual electrode. In the case of microelectrodes, the boundaries move towards high frequencies. Results showed that the effect of material selection and surface modification on impedance was more pronounced in the case of smaller electrodes. or when relatively low frequencies were used. The responses of living tissue to implants resulted in changes in the biological environment near the implanted electrodes and this led to a large increase in impedance at high frequencies. The impedance-frequency characteristic provides a guideline for a bio-electrode array design to meet a particular bio-medical application, and also an evaluation method for bio-electrode arrays.
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ItemSpeech perception in implanted children: effects of speech processing strategy and residual hearing(Mendoza Editor, 1997)The ability of implanted children to adapt to different speech processing strategies has been demonstrated for the Nucleus implant system. Children previously experienced with the Multipeak speech processing strategy. were able to gain significant improvements in consonant, word and sentence perception using the Speak speech processing strategy. suggesting some degree of neural plasticity in neural-auditory coding. Of 192 implanted children with different degrees of preoperative residual hearing, 65% were found to obtain significant scores on open-set speech materials using electrical stimulation alone. Those children with more residual hearing had a greater probability of achieving open-set understanding and at a minimum level, perceived high frequency consonant information which would not have been available through conventional hearing aids.
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ItemMulticenter evaluations of speech perception in adults and children with the nucleus (cochlear) 22-channel cochlear implant(Kugler, 1996)The Nucleus 22-channel cochlear implant has been implanted in over 10,500 patients in 79 countries. and used for more than 25 languages. It arose as a result of our early physiological, behavioral and biological research on experimental animals. The historical development of the Nucleus device has been outlined in detail by Clark. Our ongoing research has led to improvements in the way speech is processed with the 22-channel device that are now resulting in improved speech perception for profoundly totally deaf people that is, on average, better than the speech perception obtained by many deaf people with hearing aids. The multiple-channel cochlear implant was first approved by the US Food and Drug Administration (FDA) for use in postlinguistically deaf adults in 1985. It was subsequently approved for use in children in 1990. The proportion of children (18 years of age and under) to have now received it is approximately 439C (4,500 out of 10.500). In evaluating improvements in speech processing it is important to design well-controlled studies, and a number of important ones which have previously been published are summarized in this paper. In addition, speech perception results for all the Nucleus speech processing strategies have been obtained four to six months postoperatively from unselected patients presenting to the Cochlear Implant Clinic at the Royal Victorian Eye & Ear Hospital (RVEEH), Melbourne, and are presented in this paper. As results can vary greatly with different durations of experience it is essential to make comparisons at the same time postoperatively. These clinical data are the most complete to date for comparing the Nucleus speech processing strategies.
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ItemHabilitation issues in the management of children using the cochlear multiple-channel cochlear prosthesis( 1993)Since 1985, a significant proportion of patients seen In the Melbourne cochlear Implant clinic have been children. The children represent a diverse population, with both congenital and acquired hearing-impairment, a wide-range or hearing levels pre-Implant, and an age range from 2 years to 18 years. The habilitation programme developed for the overall group must be flexible enough to be tailored to the Individual needs of each child, and to adapt to the changing needs or children as they progress. Long-term data shows that children are continuing to show Improvements after 5-7 years of device use, particularly In their perception of open-set words and sentences. Habilitation programs must therefore be geared to the long-term needs of children and their families. Both speech perception and speech production need to be addressed In the specific content of the habilitation program for any Individual child. In addition, for young children, the benefits or Improved speech perception should have an Impact on development of speech and language, and the focus of the programme for this age child will reflect this difference In emphasis. Specific materials and approaches will vary for very young children, school-age and teenage children. In addition, educational selling will have a bearing on the Integration of listening and device use Into the classroom environment.
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ItemSpeech processing strategies in an electrotactile aid for hearing-impaired adults and children(Australian Speech Science and Technology Association, 1990)An electrotactile speech processor (Tickle Talker) for hearing-impaired children and adults has been developed and tested. Estimates of second format frequency, fundamental frequency and speech amplitude are extracted from the speech input, electrically encoded and presented to the user through eight electrodes located over the digital nerve bundles on the fingers of the non-dominant hand. Clinical results with children and adults confirm that tactually-encoded speech features can be recognized, and combined with input from vision or residual audition to improve recognition of words in isolation or in sentences. Psychophysical testing suggests that alternative encoding strategies using multiple-electrode stimuli are feasible. Preliminary results comparing encoding of consonant voiced/voiceless contrasts with new encoding schemes are discussed.