Graeme Clark Collection

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    A study of intra-cochlear electrodes and tissue interface by electrochemical impedance methods in vivo
    Duan, Y. Y. ; Clark, Graeme M. ; Cowan, R. S. C. ( 2004)
    Unavailable due to copyright.
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    The role of radiographic phase-contrast imaging in the development of intracochlear electrode arrays
    XU, JIN ; Stevenson, Andrew W. ; Gao, Dachao ; TYKOCINSKI, MICHAEL ; LAWRENCE, DAVID ; Wilkins, Stephen W. ; Clark, Graeme M. ; Saunders, Elaine ; Cowan, Robert S. ( 2001)
    Objective: This study describes the application of a new radiographic imaging modality, phase-contrast radiography, to in vitro human temporal bone imaging and investigates it use in the development of new electrode arrays for cochlear implants. Background: The development of perimodiolar electrode arrays for cochlear implants requires detailed information from postoperative radiologic assessment on the position of the array in relation to the cochlear structures. Current standard radiographic techniques provide only limited details. Materials and Methods: Nucleus standard electrode arrays and perimodiolar Contour electrode arrays were implanted into the scala tympani of 11 human temporal bones. Both conventional and phase-contrast radiographs were taken of each temporal bone for comparative purposes. Results: Phase-contrast imaging provides better visulization of anatomic details of the inner ear and of the structure of the intracochlear electrode array, and better definition of electrode location in relation to cochlear walls. Conclusion: Phase-contrast radiography offers significant improvement over conventional radiography in images of in vitro human temporal bones. It seems to be a valuable tool in the development of intracochlear electrode arrays and cochlear implant research. However, this new radiographic technique still requires certain computational and physics challenges to be addressed before its clinical use can be established.
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    The Contour electrode array: Safety study and initial patient trials of a new perimodiolar design
    Tykocinski, M ; Saunders, E ; Cohen, LT ; Treaba, C ; Briggs, RJS ; Gibson, P ; Clark, GM ; Cowan, RSC (LIPPINCOTT WILLIAMS & WILKINS, 2001-01)
    OBJECTIVE: The aim of these studies was to investigate the insertion properties and safety of a new intracochlear perimodiolar electrode array design (Contour). BACKGROUND: An electrode array positioned close to the neural elements could be expected to reduce stimulation thresholds and might potentially reduce channel interaction. METHODS: Two sequential studies were conducted. In study 1, the Contour electrode array was inserted in 12 human temporal bones. After cochlear surface preparation, the position of the array was noted and the basilar membrane was examined for insertion damage. On the basis of the outcome of this temporal bone study, study 2 investigated the Contour array, mounted on a Nucleus CI-24 M device and implanted in three adult patients. RESULTS: Study I showed that in 10 temporal bones, the Contour array was positioned close to the modiolus, and the basilar membrane was intact. In the two remaining bones, the arrays had pierced the basilar membrane and were positioned in the scala vestibuli apical to the penetration. Statistical analysis showed an equivalent probability of insertion-induced damage of the two array designs. In study 2, image analysis indicated that the Contour electrodes were positioned closer to the modiolus than the standard Nucleus straight array. Lower T and C levels, but higher impedance values, were recorded from electrodes close to the modiolus. Initial speech perception data showed that all patients gained useful open-set speech perception, two patients achieving scores of 100% on sentence material 3 months postoperatively. CONCLUSIONS: The temporal bone studies showed the Contour electrode array to be generally positioned closer to the modiolus than the standard Nucleus straight array, and to have an equivalent probability of causing insertion-induced damage.
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    A comparison of a new prototype Tickle Talker with a Tactaid 7
    Galvin, Karyn L. ; Ginis, Jan ; Cowan, Robert S. C. ; Blamey, Peter J. ; Clark, Graeme M. ( 2001)
    This study compared the speech perception enhancement provided by two multichannel tactile aids: a new version of the Tickle TalkerT™ and the Tactaid 7. The subjects' impression of benefit was also examined. In an AB pattern, six adults with hearing impairment used each device daily for approximately 18 weeks and attended 12 training sessions. When tactile information was provided, the group demonstrated a significant enhancement for the perception of words (mean 17.2%) and phonemes (mean 12.9%) in monosyllabic word lists, words in sentences (mean 14.2%) and speech tracking (mean 7.7 wpm). The Tactaid 7 provided a significantly greater enhancement for the perception of words (21 % versus 13.4%), phonemes (16.7% versus 9.1%) and some speech features in monosyllabic word lists. Subjective ratings were slightly higher for the Tactaid 7, and four subjects preferred this device. Either device may be suitable for those not able or willing to have a cochlear implant.
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    Comparison of electrode position in the human cochlea using various perimodiolar electrode arrays
    TYKOCINSKI, MICHAEL ; Cohen, Lawrence T. ; Pyman, Brian C. ; Roland (Jr), Thomas ; Treaba, Claudiu ; PALAMARA, JOSEPH ; Dahm, Markus C. ; Shepherd, Robert K. ; XU, JIN ; Cowan, Robert S. ; Cohen, Noel L. ; Clark, Graeme M. ( 2000)
    Objective: This study was conducted to evaluate the insertion properties and intracochlear trajectories of three perimodiolar electrode array designs and to compare these designs with the standard Cochlear /Melbourne array. Background: Advantages to be expected of a perimodiolar electrode array include both a reduction in stimulus thresholds and an increase in dynamic range, resulting in a more localized stimulation pattern of the spiral ganglion cells, reduced power consumption, and, therefore, longer speech processor battery life. Methods: The test arrays were implanted into human temporal bones. Image analysis was performed on a radiograph taken after the insertion. The cochleas were then histologically processed with the electrode array in situ, and the resulting sections were subsequently assessed for position of the electrode array as well as insertion-related intracochlear damage. Results: All perimodiolar electrode arrays were inserted deeper and showed trajectories that were generally closer to the modiolus compared with the standard electrode array. However, although the precurved array designs did not show significant insertion trauma, the method of insertion needed improvement. After insertion of the straight electrode array with positioner, signs of severe insertion trauma in the majority o fimplanted cochleas were found. Conclusions: Although it was possible to position the electrode arrays close to the modiolus, none of the three perimodiolar designs investigated fulfilled satisfactorily all three criteria of being easy, safe, and a traumatic to implant.
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    Generalisation of tactile perceptual skills to new context following tactile-alone word recognition training with the Tickle Talker
    Galvin, Karyn L. ; Blamey, Peter J. ; Cowan, Robert S. C. ; Oerlemans, Michael ; Clark, Graeme M. ( 2000)
    Abstract not available due to copyright.
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    The effect of language knowledge on speech perception: what are we really assessing?
    Sarant, Julia Z. ; Blamey, Peter J. ; Cowan, Robert S. ; Clark, Graeme M. ( 1997)
    Objective: The authors examined whether open-set speech perception scores are limited by knowledge of vocabulary and syntax and further considered whether remediation of vocabulary and syntax will increase open-set speech perception scores. Study Design: This was a repeated-measures study design in the setting of a primary (elementary) school for the hearing impaired. Patients: The study population was composed of three hearing-impaired children using Nucleus 22-channel cochlear implant. Intervention: Intervention used was language remediation sessions. Main Outcome Measures: The main outcome measures were assessment of auditory-alone speech perception benefit using open-set words and sentences and assessment of syntactic knowledge using the Test of Syntactic Ability. Outcome measures were applied before and after remediation. Results: Child 1 and child 2 showed a significant postremediation improvement in their overall scores on the Test of Syntactic Ability and in their ability to perceive words learned during remediation. Child I and child 2 also showed a significant improvement in their scores on a modified Bamford-Kowal-Bench open-set sentence test, which specifically targeted grammatical constructs trained in remediation sessions. Conclusions: Remediation of language knowledge deficits significantly improved open-set speech perception for two children, suggesting a need to include language remediation in cochlear implant habilitation programs.
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    Speech perception results for children with implants with different levels of preoperative residual hearing
    Cowan, Robert S. C. ; DelDot, J. ; Barker, J. Z. ; Barker, Elizabeth J. ; Sarant, Julia Z. ; Pegg, P. ; Dettman, S. ; Galvin, K. L. ; Rance, G. ; Hollow, R. ; Dowell, R. C. ; Pyman, B. ; Gibson, W. P. R. ; Clark, Graeme, M. ( 1997)
    Objective: Many reports have established that hearing-impaired children using the Nucleus 22 channel cochlear implant may show both significant benefits to lipreading and significant scores on open-set words and sentences using electrical stimulation only. These findings have raised questions about whether severely or severely-to-profoundly deaf children should be candidates for cochlear implants. To study this question, postoperative results for implanted children with different levels of preoperative residual hearing were evaluated in terms of speech perception benefits. Study Design/Setting: A retrospective study of the first 117 children, sequentially, to undergo implantation in the Melbourne and Sydney Cochlear Implant Clinics was undertaken. All children had been assessed by and received their implants in a tertiary referral centre. Main Outcome Measures: To assess aided residual hearing, the children were grouped into four categories of hearing on the basis of their aided residual hearing thresholds measured preoperatively. To assess benefits, the scores of children on standard speech perception tests were reviewed. As different tests were used for children with different ages and language skills, children were grouped into categories according to the level of postoperative speech perception benefit. Results: The results showed that children in the higher categories of aided preoperative residual hearing showed significant scores on open-set word and sentence perception tests using the implant alone. For children in lower categories of aided residual hearing, results were variable within the groups. More than 90% of children with implants with aided residual hearing thresholds in the speech range above I kHz achieved open-set understanding of words and sentences. Conclusion: While the results of this preliminary study confirm previous findings of differential outcomes for children with different levels of preoperative residual hearing, they suggest that children with severe to profound hearing impairments should be considered for cochlear implantation.
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    Acquisition of a tactile-alone vocabulary by normally hearing users of the Tickle Talker
    Galvin, Karyn L. ; Blamey, Peter J. ; Oerlemans, Michael ; Cowan, Robert S. C. ; Clark, Graeme M. ( 1999)
    Abstract not available due to copyright.
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    A modification of play audiometry to assess speech discrimination ability in severe-profoundly deaf 2- to 4-year-old children
    Dawson, P. W. ; Nott, P. E. ; Clark, Graeme M. ; Cowan, Robert S. C. ( 1998)
    Objective: The aim was to develop an assessment procedure that was independent of language and speech production ability, to test speech feature discrimination severe-profoundly deaf children 2 to 4 yr of age. Design: The procedure being trialled was adapted from existing procedures. The child was required to respond with a game-like motor response to a “change” in a speech stimulus that was being presented repeatedly through a speaker. The change occurred at randomly determined times, and false alarm responses were measured during the waiting periods (while the child waited for the change). Two- to four-yr-old normally hearing children and hearing-impaired children using hearing aids and a group of 4-yr-old hearing-impaired children using cochlear implants were assessed on the task. Results: More than 82% of the 3- and 4-yr-old normally hearing and hearing-impaired children were able to complete the testing for the eight speech sound contrasts within three 20 minute sessions. Fifty percent of the 2-yr-old normally hearing and hearing-impaired children were able to condition and complete the task. All of the normally hearing children who completed the task successfully discriminated all speech sound contrasts. The performance of the hearing-impaired children using hearing aids was influenced by the degree of hearing loss and the type of speech contrast being tested. Similarly, the average performance of the children using cochlear implants was better for easier contrasts such as /ba/bi/ with contrasting vowel formant cues. Conclusions: This procedure has potential for use as a reliable clinical and research tool for assessing the development of auditory discrimination ability in 2- to 4-yr-old severe-profoundly deaf children.