Graeme Clark Collection
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ItemCochlear implants: a personal scientific journey [Abstract]( 2002)Electrical stimulation of the auditory system to reproduce hearing commenced through academic curiosity, and the hope of helping deaf people. It received direction from neurophysiology, and later psychophysics and speech science. In the 1960s and 1970s there were many questions requiring answers before cochlear implants could become a practical reality. Key concerns were: (1) the cochlea was too complex for electrical stimulation to reproduce the coding of sound; (2) multiple electrodes inserted into the cochlea for the place coding of frequency could damage the auditory nerves to be stimulated; (3) speech was too complex to be reproduced by electrical stimulation; and (4) children born deaf would not develop the appropriate neural connectivity for speech understanding. The first questions were addressed on the experimental animal. Speech research on patients was only possible with the advent of silicon chip technology allowing the development of an implantable receiver-stimulator package. Initial research established proof of principle that connected discourse was possible with multiple electrode stimulation of the auditory nerve in severely and profoundly deaf people. The research has been developed industrially for the benefits to be provided on a widespread basis through clinics worldwide. Further research has resulted in continuing improvements so that the average profoundly deaf person can hear as well as someone with severe hearing loss using a hearing aid. There is still much research required to achieve high fidelity sound, hearing in noise, and totally implantable devices.
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ItemHistopathology of the binaural cochlear implant subject [Abstract]( 2001)Binaural hearing improves speech reception in noise, and is necessary for sound localisation. Normal hearing subjects use both interaural time, and intensity, differences to localise sound. This study investigates why sound localisation in bilateral cochlear implantees is insensitive to interaural time differences (Hoesel 1993). We looked for evidence of neural degeneration in the auditory brainstem involved in binaural sound localisation, since this may have degraded the neural circuitry required to accurately code interaural time delays. Method: The brainstem of a bilateral cochlear implantee was prepared for light microscopy by embedding it in paraffin, sectioning at 10 mm and staining sections with thionine or Luxol fast blue (LFB). The histological sections were digitised with NIH Image and 3-dimensional reconstructions made of the cochlear nucleus (CN) and superior olivary complex (SOC) with AnalysePC. Within the CN and the SOC, cell number and size were estimated by the physical dissector technique following thionine staining, and myelination of the nerve fibres was estimated using the optical density method following LFB staining. Results: A reduction in cell size (from thionine staining) and myelination (from LFB staining) was seen in both the CN and the SOC. Conclusions: These finding are consistent with neural degeneration within the auditory pathways. This may have lead to a degradation of the neural circuitry required to accurately detect interaural time delays.
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ItemSpeech perception in implanted children: influence of preoperative residual hearing on outcomes [Abstract]( 1998)Since the first child was implanted with the Nucleus 22-channel prosthesis in Melbourne in 1985, several thousand children world-wide have now benefitted from this technology. More effective paediatric assessment and management procedures have now been developed, allowing cochlear implants to be offered to children under the age of 2 years. Improvements in speech processing strategy have also been implemented in the Nucleus implant system, resulting in increased mean speech perception benefits for implanted adults. Although a range of performance on formal measures of hearing, speech or language has been reported for children using implants, results from the first decade of implant experience consistently show that significant benefits are available to children receiving their implant at an early age. Reported speech perception results for implanted children show that a considerable proportion (60%) of paediatric patients in the Melbourne and Sydney clinics are able to understand some open-set speech using electrical stimulation alone. These results, and the upward trend of mean speech perception benefits shown for postlinguistically deafened adults have raised questions as to whether severely, or severely-to-profoundly deaf children currently using hearing aids would in fact benefit more from a cochlear implant. To investigate the potential influence of the degree of preoperative residual hearing on postoperative speech perception, results for all implanted children in the Melbourne and Sydney cochlear implant programs were analysed. Results showed that as a group, children with higher levels of preoperative residual hearing were consistently more likely to achieve open-set speech perception benefits. Potential factors in this finding could be higher levels of ganglion cell survival or greater patterning of the auditory pathways using conventional hearing aids prior to implantation. Conversely, children with the least preoperative residual hearing were less predictable, with some children achieving open-set perception, and others showing more limited closed-set benefits to perception. For these children, it is likely that preoperative residual hearing is of less significance than other factors in outcomes.
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ItemPreoperative residual hearing as a predictor of postoperative speech scores for adult cochlear implant users [Abstract]( 1994)The development of multiple channel cochlear implants has been a significant advance in the rehabilitation of profound hearing loss. Speech perception benefits have been particularly evident for postlinguistically deafened adults, who as a group have shown not only supplementation of lipreading scores but also significant comprehension of words and sentences using an implant alone, without the aid of lipreading. In many cases, patients are able to use their implant for telephone conversation. Speech perception benefits for adult users have increased with advances in speech processing and improved means of habilitation. These improvements in open-set speech benefits for adult users have resulted in a steady increase in group mean scores and a reevaluation of selection criteria for cochlear implantation. In the initial development of cochlear implants, only those with little or no residual hearing were considered as candidates. Current selection criteria now include those with substantial residual hearing, who may score up to 40% in the best-aided condition on word and sentence speech perception tests. In order to provide realistic expectations for prospective cochlear implant patients, it is important to establish the relationship of many preimplant factors to postimplant speech perception benefits. For severely hearing impaired adults, the relationship between preoperative residual hearing, as measured by aided word and sentence speech perception test scores, and postoperative speech perception benefits is of significant interest. Analysis of data collected over a 15 year period for adult patients is presented. The rationale for conducting full speech perception assessments for all potential cochlear implant patients is stressed.
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ItemCombined cochlear implant and speech processing hearing aid for implant users with a severe to profound hearing loss in the contralateral ear [Abstract]( 1994)The bimodal device was developed for cochlear implant users who simultaneously wear a hearing aid in the opposite ear having residual hearing of a severe to profound degree. The aim was to create a single device to provide both input signals in a more compatible manner and thus maximise use of the individual's total hearing capabilities. The acoustic component of the bimodal device is very flexible and can implement various speech processing strategies with speed, ease and precision. The Frequency Response Tailoring strategy utilises three filters to fit a frequency gain curve to within 1-2 dB of that desired. Modifications at discrete frequencies, ranges or slopes can be readily made. The Peak Sharpening or Spectral Enhancement strategy amplifies the formant peaks in speech for potential improvement of formant resolution and speech perception in the presence of background noise. The Resynthesis strategy presents specifically selected components of speech in selected combinations and includes the ability to transpose higher frequency information to lower frequency ranges for individuals with no aidable high frequency hearing levels. Different fits can be quickly and easily interchanged for comparison and evaluation and subsequent modifications indicated can be readily effected. Any combination of acoustic and implant speech processing strategy can be presented to optimise speech perception for the individual user.
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ItemThe evolution continues: the clinical trials of the SPEAK strategy in Nucleus 22 channel cochlear implant users [Abstract]( 1994)Research in the field of cochlear implants continues in centres around the world. The aim of all centres is to improve the speech perception abilities of those children and adults fitted with a cochlear implant. Most recently the work of Hugh McDermott and Colette McKay (Melbourne University, Department of Otolaryngology) in developing and researching the SMSP (Spectral Maxima Sound Processor) has greatly enhanced the speech understanding abilities of a number of subjects implanted with the Nucleus 22 Channel Cochlear Implant.
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ItemPlace pitch perception with multiple electrode cochlear implants: the use of concurrent activation of nearby electrodes to produce additional ptich percepts [Abstract]( 1992)In multiple electrode cochlear implants, each electrode produces a pitch percept which is usually related monotonically to its distance from the round window. The number of these pitch percepts is limited by the number of usable electrodes and their discriminability, varying up to a maximum of 22 for the mini-system 22 implant but sometimes significantly less. A study on two implanted subjects in which the pitch of pulse trains on two concurrently activated nearby electrodes was compared with the pitch produced when each of the electrodes was activated on its own, showed that the pitch of the concurrently activated electrodes was different from each component electrode and was placed in an intermediate position. Furthermore the pitch of the concurrent stimulation could be altered by adjusting the relative current levels on the two component electrodes. This may partly explain the improvements, particularly in vowel discrimination, obtained with the SMSP strategy described in the accompanying paper.
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ItemDiscrimination of electrical trajectories by cochlear implant patients [Abstract]( 1990)Abstract not available due to copyright.
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ItemResults in children using the 22 electrode cochlear implant [Abstract]( 1989)Abstract not available due to copyright.
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ItemStudies in tactile speech perception using the University of Melbourne Tickle Talker [Abstract]( 1998)During the past four years, a series of studies have been undertaken investigating the perception of speech presented through the tactile modality. These studies formed part of a project to develop an effective and safe electro tactile speech perception device for those children and adults requiring additional communication assistance to that provided by hearing aids, but unable to benefit from cochlear implants.