Graeme Clark Collection
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ItemInner ear implants(Dekker, 2004)The cochlear implant is an electronic device that brings useful hearing to severely to profoundly deaf people through multiple-channel electrical stimulation of the auditory nerves in the inner ear. This is required if their inner ears are so badly damaged by injury and disease, or so inadequately developed, that they cannot provide sufficient hearing for communication, even when the sound is amplified with a hearing aid. By stimulating the nerve directly with patterns of electrical pulses, the implant bypasses the normal function of the sense organ of hearing in the inner ear to partially reproduce the coding of sound. It consists of a wearable speech processor that picks up sound with a microphone, analyzes the signal, and then sends it by radio waves to the implanted receiver stimulator, which decodes the message and stimulates the electrode wires inserted into the inner ear.
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ItemChronic electrical stimulation of the auditory nerve using non-charge-balanced stimuli( 1999)This study was designed to evaluate the pathophysiological response of the cochlea following long-term intracochlear electrical stimulation using a poorly charge-balanced stimulus regime, leading to direct current (DC) levels >0.1 µA. Four normal-hearing adult cats were bilaterally implanted with scala tympani electrode arrays and unilaterally stimulated for periods up to 2200 h. Stimuli consisted of 50 µs monophasic current pulses presented at 2000 pulses per second (pps) per channel, and resulted in DC levels of 0.4-2.8 µA. Both acoustic and electrical (EABR) evoked potentials were periodically recorded during the stimulation program. Frequency-specific stimuli indicated that an extensive and widespread hearing loss occurred over the 4-24 KHz region in all stimulated cochleae, although the 2 KHz region exhibited thresholds close to normal in some animals, despite long-term implantation and chronic stimulation. Longitudinal EABRs showed a statistically significant increase in threshold for three of the four animals. Histopathological evaluation of the cochleae revealed a highly significant reduction in ganglion cell density in stimulated cochleae compared with their controls. Spiral ganglion cell loss was significantly correlated with the degree of inflammation, duration of electrical stimulation, and the level of DC. In conclusion, the present study highlights the potential for neural damage following stimulation using poorly charge-balanced stimuli.
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ItemControl strategies for neurons modeled by self-exciting point processes( 1996)Abstract not available due to copyright.
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ItemElectrical stimulation of the auditory nerve: the coding of frequency, the perception of pitch and the development of cochlear implant speech processing strategies for profoundly deaf people( 1996)1. The development of speech processing strategies for multiple-channel cochlear implants has depended on encoding sound frequencies and intensities as temporal and spatial patterns of electrical stimulation of the auditory nerve fibres so that speech information of most importance for intelligibility could be transmitted. 2. Initial physiological studies showed that rate encoding of electrical stimulation above 200 pulses/s could not reproduce the normal response patterns in auditory neurons for acoustic stimulation in the speech frequency range above 200 Hz and suggested that place coding was appropriate for the higher frequencies. 3. Rate difference limens in the experimental animal were only similar to those for sound up to 200 Hz. 4. Rate difference limens in implant patients were similar to those obtained in the experimental animal. 5. Satisfactory rate discrimination could be made for durations of 50 and 100 ms, but not 25 ms. This made rate suitable for encoding longer duration suprasegmental speech information, but not segmental information, such as consonants. The rate of stimulation could also be perceived as pitch, discriminated at different electrode sites along the cochlea and discriminated for stimuli across electrodes. 6. Place pitch could be scaled according to the site of stimulation in the cochlea so that a frequency scale was preserved and it also had a different quality from rate pitch and was described as tonality. Place pitch could also be discriminated for the shorter durations (25 ms) required for identifying consonants. 8. As additional speech frequencies have been encoded as place of stimulation, the mean speech perception scores have continued to increase and are now better than the average scores that severely-profoundly deaf adults and children with some residual hearing obtain with a hearing aid.
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ItemAcute effects of high-rate stimulation on auditory nerve function in guinea pigs( 1995)Cochlear implants have been shown to successfully provide profoundly deaf patients with auditory cues for speech discrimination. Furthermore, a number of safety studies using the Melbourne/Cochlear electrode array indicated that chronic electrical stimulation using charge-balanced biphasic current pulses and stimulus rates between 100 and 500 pulses per second (pps) do not result in additional spiral ganglion loss or general cochlear pathology.1-3 However, safe maximum levels for stimulus parameters (stimulus rate, charge per phase, charge density) have not yet been adequately defined.
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ItemCochlear implants: future research directions( 1995)The future of cochlear implants for profoundly deaf people now seems assured, and further research should improve its benefits. The present benefits of cochlear implants have now been clearly demonstrated. The results have shown that many postlingually deaf adults get significant open-set speech recognition using electrical stimulation alone, and that profoundly deaf children with a cochlear implant get better speech perception than similar children who use hearing aids or tactile vocoders.
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ItemCross-fiber interspike interval probability distribution in acoustic stimulation: a computer modeling study( 1995)Electrical stimulation strategies for cochlear implants may be improved by studying temporal frequency coding in single auditory fibers and across fibers in acoustic stimulation (Clark et al, this suppl, section 5). In single nerve fibers, phase locking between action potentials and the acoustic stimulus can only be maintained at frequencies below about 600 Hz. At these frequencies, the time interval between successive action potentials, called the interspike interval (lSI), is distributed around the period of the stimulus, and it can therefore be used to code frequency within single fibers. At higher frequencies, the phase locking of individual nerve fibers diminishes, but it may still be possible to retain phase-locking properties by combining the action potentials in an ensemble of nerve fibers. In an ensemble of fibers, the lSI in each nerve is affected by factors such as the spectral shape of the stimulus, the characteristic frequency, and the firing characteristics of the nerve. The lSI between the fibers, however, is further affected by the propagation or phase delay of the traveling wave. It is therefore uncertain how these factors would affect frequency coding across fibers. It is possible that the propagation delay between the fibers may lower the phase locking in an ensemble of nerves -because the probability that the majority of nerves in an ensemble will fire simultaneously may be low. It is also possible that the combined firing statistics of the fibers in an ensemble may result in a higher degree of synchrony such that the predominant intervals in an ensemble are preserved over a wider frequency range than in a single fiber. Are these accurate postulations of the physical system? In a future electrical stimulation strategy that incorporates temporal frequency coding, is it necessary to mimic the spatial-temporal delay in the firing patterns caused by the traveling wave? These are important questions that need to be studied and answered. (From Introduction)
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ItemSignal processing for multichannel cochlear implants: past, present and future [Abstract]( 1994)Since the late 1970's, many groups have worked on developing effective signal processing for multichannel cochlear implants. The main aim of such schemes has been to provide the best possible speech perception for those using the device. Secondary aims of providing awareness and discrimination of environmental sounds and appreciation of music have also been considered. Early designs included some that attempted to simulate the normal cochlea. The application of such complex processing schemes was limited by the technology of the times. In some cases, researchers reverted to the use of single channel systems which could be controlled reliably with the existing technology. In other cases, as with the Australian implant, a simple multichannel processing scheme was devised that allowed a reliable implementation with available electronics. Over the next 15 years, largely due to the improvements in integrated circuit technology, the signal processors have slowly become more complex. Further psychophysical research has shown how additional information can be transferred effectively to implant users via electrical stimulation of the cochlea. This has lead to rapid improvement in the speech perception abilities of adults using cochlear implants. Some of the main developments in signal processing over the last 15 years will be discussed along with the latest speech perception results obtained with the new SPEAK processing scheme for the Australian 22-channel cochlear implant. Initial results for SPEAK show mean scores of 70% (equivalent to 85-90% phoneme scores) for open set monosyllabic word testing for experienced adult users. Although there remains a large range of performance for all users of cochlear implants, average speech perception scores for all implanted adults have also improved significantly with the developments in signal processing. It appears likely that multichannel cochlear implants will be a viable alternative for the treatment of severe hearing loss in the future.
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ItemPsychophysics of electrical stimulation of the auditory nerve: implications for coding of sound and speech processing for cochlear implants [Keynote address]( 1994)Psychophysical studies on electrical stimulation of the auditory nerve have contributed to our understanding of the coding of sound and speech signals. Those studies have also helped establish speech processing strategies for multiple-electrode cochlear implant patients. The first studies were on temporal coding of frequency and pitch perception to help determine whether a single or multiple electrode implant would be preferable for the coding of speech frequencies. Temporal frequency coding was initially studied in the experimental animal by measuring difference limens for frequency of stimulus rate. The results showed that rate coding occurs for low frequencies up to 200 or even 600 pulses per second. It was concluded that higher speech frequencies cannot be conveyed by variations in stimulus rate but require multiple-electrode stimulation. These studies in experimental animals were essentially confirmed in the human.