Graeme Clark Collection

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    Speech perception benefits for implanted children with preoperative residual hearing [Abstract]
    Hollow, R. ; Rance, G. ; Dowell, R.C. ; Pyman, B. ; Clark, Graeme M. ; Cowan, R. S. C. ; Galvin, K. L. ; Barker, E. J. ; Sarant, J. Z. ; Dettman, S. ( 1995)
    Since the implantation of the first children with the Nucleus 22-channel cochlear prosthesis in Melbourne in 1985, there has been rapid expansion in the number of implanted children world-wide. Improved surgical technique and experience in paediatric assessment and management have contributed to a trend to implant very young children. At the same time there has also been continuing development of improved speech processing strategies resulting in greater speech perception benefits. In the Melbourne program, over 60% of children obtain significant scores on open-set word and sentence tests using their cochlear implant alone without the aid of lipreading. As parents and professionals have become aware of these improved benefits to speech perception benefits in profoundly deaf children, there have been requests to consider implanting severely-to-profoundly deaf children. In these children with higher levels of residual hearing, only those children with poorer-than-expected performance on speech perception tests using hearing aids have been considered for surgery. A number of such cases have now been implanted in the Melbourne program. The speech perception benefits for this group are reported and are being compared with benefits for the profoundly deaf group of children.
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    Results of multichannel cochlear implantation in very young children [Abstract]
    Galvin, K. ; Clark, Graeme M. ; Dettman, S. ; Dowell, R. ; Barker, E. ; Rance, G. ; Hollow, R. ; Cowan, R. ( 1995)
    Most researchers and clinicians working in the cochlear implant field have assumed that profoundly deaf children will have a better prognosis in terms of speech perception, speech production and language development. if implanted at as young an age as possible. However, it has been difficult to gather direct evidence for this hypothesis due to the problems in assessing children under the age of five years with formal tests. Recent results with older children have supported the view that early implantation may provide the optimal outcome in most cases. The implantation of very young children raises two areas of concern that do not apply in adults and older children: accurate assessment of degree of hearing loss and auditory potential; and postoperative assessment of outcomes. This paper will describe research results from the University of Melbourne which address these issues and present results for children implanted as young as eighteen months of age.
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    Physiological and histopathological response of the cochlea to chronic electrical stimulation of the auditory nerve at high stimulus rates [Abstract]
    Shepherd, R. K. ; Xu, J. ; Clark, Graeme M. ( 1994)
    Previous research has shown that chronic electrical stimulation of the auditory nerve using charge balanced biphasic current pulses at rates of up to 500 pulses per second (pps) does not adversely affect the adjacent spiral ganglion population. More recently, a number of clinical trials have suggested that speech processing strategies based on high pulse rates (e.g. 1000 pps), can further improve speech perception. In the present study we evaluated the physiological and histopathological response of the cochlea following long-term stimulation using rates of 1000 pps. Thirteen normal hearing cats were bilaterally implanted with scala tympani electrodes and unilaterally stimulated using 25-50 �s per phase charge balanced biphasic current pulses presented at 1000 pps. Additional charge balance was achieved by shorting the electrodes between current pulses. Each animal was stimulated for periods ranging from 700 - 2100 hours at current levels within its dynamic range. Auditory brainstem responses to both acoustic (ABR) and electrical (EABR) stimuli were periodically recorded throughout the chronic stimulation program. At completion of the program the cochleas were prepared for histological examination. While all animals exhibited an increase in acoustic thresholds following surgery, click evoked ABR's returned to near normal levels in half the animals. Frequency specific stimuli indicated that the most extensive hearing loss occurred adjacent to the array (>12 kHz) while lower frequency thresholds appeared at or near normal Our EABR data showed that the majority of animals exhibited slight increases in threshold, although response amplitudes remained very stable for the duration of the stimulus program. The physiological data reported here will be correlated with cochlear histopathology. These initial findings suggest that chronic intracochlear electrical stimulation at high pulse rates, using a carefully designed charge balanced stimulator, does not appear to adversely affect the implanted cochlea.
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    Results for the Nucleus multiple-electrode cochlear implant in two children [Abstract]
    Tong, Y. C. ; Blamey, P. J. ; Dowell, R. C. ; Nienhuys, T. G. ; Musgrave, G. N. ; Busby, P. A. ; Roberts, S. A. ; Rickards, F. W. ; Dettman, S. J. ; Altidis, P. M. ; Clark, Graeme M. ( 1988)
    Two males, 9 years 10 months (CHILD 1) and 5 years 5 months (CHILD 2) at time of surgery, were implanted with the Nucleus multiple-electrode cochlear implant. Both patients were deafened as a result of meningitis in their third year. Assessments of speech perception, speech production and language skills were undertaken at regular intervals, pre and post operatively. For both patients in the audition alone condition, some speech perception post operative scores were significantly higher than pre operative scores and progressive improvements in scores over successive post operative data collection times were seen. Significant differences between the visual alone and auditory-visual condition scores were also observed for CHILD 1 post operatively. Speech production post operative scores were significantly higher than pre operative scores for both patients. The receptive vocabulary scores for both patients improved at a higher rate than that of age-matched normal children. The acquisition of expressive and receptive language skills for CHILD 2 was at a higher rate than that of age-matched children. Differences in the results between the two patients were seen, and this may be related to age and duration of deafness.