Minerva Elements Records
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ItemCultural wars in an Australian context: challenges in developing a national cultural policy(ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD, 2015-03-15)In March 2013, the Australian Federal Labor Government released Creative Australia. This document was described as the first national Cultural Policy statement in 20 years since the publication by a previous Labor Government of Creative Nation in 1994. However, within 6 months of the launch of this new policy, a Coalition (Conservative) Federal government was elected in September 2013. Up till now, Coalition Governments have rejected the need for a national cultural policy, so the future for Creative Australia may in fact be both contested and limited. Indeed, during the previous Federal Coalition Government a ‘cultural war’ erupted between the government and artists and intellectuals, over the latter’s desire for an Australian cultural policy. This paper addresses questions around the process of developing this new national cultural policy, why it occurred, and what future it might have now there is a new Coalition Federal Government in power.
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ItemAuditor Style and Financial Statement Comparability(American Accounting Association, 2014-03-01)The term “audit style” is used to characterize the unique set of internal working rules of each Big 4 audit firm for the implementation of auditing standards and the enforcement of GAAP within their clienteles. Audit style implies that two companies audited by the same Big 4 auditor, subject to the same audit style, are more likely to have comparable earnings than two firms audited by two different Big 4 firms with different styles. By comparable we mean that two firms in the same industry and year will have a more similar accruals and earnings structure. For a sample of U.S. companies for the period 1987 to 2011, we find evidence consistent with audit style increasing the comparability of reported earnings within a Big 4 auditor's clientele.
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ItemThe prevalence and clinicopathological features of programmed death-ligand 1 (PD-L1) expression: a pooled analysis of literatures(IMPACT JOURNALS LLC, 2016-03-22)BACKGROUND & AIMS: Programmed death-ligand 1 (PD-L1) has been recognized as a critical and promising target in therapies that direct immune escape of cancers. However, its association with aggressive clinicopathological features in solid tumors remains unclear. We investigated this question by synthesizing published articles. METHODS: Electronic databases were searched for relevant studies. Outcomes of interest included age, gender, tumor size, tumor size, lymph node metastasis and tumor cell differentiation. RESULTS: A total of 61 studies involving 17 types of malignancies were included. The overall expression rate of PD-L1 was 44.5% (95% CI, 37.5% to 51.6 %). Patients with regional lymph node metastases (OR 1.38; P < 0.01), large size tumor (OR 1.89; P < 0.01) or poor differentiated tumors (OR 1.71; P < 0.01) were associated with higher PD-L1 expression rate. However, no significant association was observed between young and elder patients (OR 1.04; P = 0.58), or male and female patients (OR 1.13; P = 0.06). A numerically higher PD-L1 expression rate was detected in polyclonal antibodies (57.2%) than monoclonal antibodies (39.6%). In addition, the PD-L1 expression rate reported by studies from Asian areas (52.3%) was numerically higher than those from non-Asian areas, namely Caucasians (32.7%). CONCLUSIONS: This meta-analysis indicated that patients with larger tumors, regional lymph node metastases, or poor-differentiated tumors were associated with a higher PD-L1 expression rate; in addition the expression rate of PD-L1 in Asians might be higher than that of Caucasians. This information might be useful in screening candidates for relevant tests and treatments.
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ItemAdoptive Immunotherapy in Postoperative Non-Small-Cell Lung Cancer: A Systematic Review and Meta-Analysis(PUBLIC LIBRARY SCIENCE, 2016-09-12)BACKGROUND: Adoptive immunotherapy (AI) has been applied in the treatment of non-small-cell lung cancer (NSCLC) patients, but the value of postoperative AI has been inconclusive largely as a result of the small number of patients included in each study. We performed a systematic review and meta-analysis to address this issue for patients with postoperative NSCLC. METHODS: Pubmed, Embase, Cochrane Library were searched for randomized controlled trials comparing adoptive immunotherapy with control therapies in postoperative NSCLC patients. The primary endpoint was overall survival. Hazard ratio (HR) was estimated and 95% confidence intervals (CI) were calculated using a fixed-effect model. RESULTS: Compared with control therapies, analyses of 4 randomized controlled trials (472 patients) showed a significant benefit of adoptive immunotherapy on survival (hazard ratio [HR] 0.61, 95% CI 0.45-0.84, p = 0.002), and a 39% reduction in the relative risk of death (no evidence of a difference between trials; p = 0.16, I² = 42%). In subgroup analyses by treatment cycles and treatment regimen, significant OS benefit was found in combination therapy of AI with chemotherapy, regardless of whether or not the treatment cycles were more than 10 cycles. CONCLUSION: Adoptive immunotherapy has the potential to improve overall survival in postoperative NSCLC. The findings suggest this is a valid treatment option for these patients. Further randomized clinical trials are urgently needed.
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ItemIguanodon and Megalosaurus: Two Victorian-era dinosaur models in the Tiegs Museum(Cultural Collections Unit, University of Melbourne Library, 2016)The Tiegs Museum at the University of Melbourne, as well as being an important zoology teaching resource for new generations of students, also serves as a tangible link to the scientific traditions of the 19th and 20th centuries. The collection includes many items from those times, such as spirit-preserved animals housed in elegant handmade jars, animal taxidermy from all over the world, and plaster casts of fossils. The Victorian era, in particular, was an exciting and revolutionary time for the life sciences, and the University of Melbourne, although geographically removed from much of the action, was very much a part of these developments. One of the many innovations
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ItemManaging stress and anxiety through qigong exercise in healthy adults: a systematic review and meta-analysis of randomized controlled trials(BMC, 2014-01-10)BACKGROUND: An increasing number of studies have documented the effectiveness of qigong exercise in helping people reduce psychological stress and anxiety, but there is a scarcity of systematic reviews evaluating evidence from randomized controlled trials (RCTs) conducted among healthy subjects. METHODS: Thirteen databases were searched for RCTs from their inception through June 2013. Effects of qigong exercise were pooled across trials. Standardized mean differences (SMDs) were calculated for the pooled effects. Heterogeneity was assessed using the I2 test. The risk of bias was assessed using the Cochrane criteria. RESULTS: Seven RCTs met the inclusion criteria. Two RCTs suggested that qigong exercise immediately relieved anxiety among healthy adults, compared to lecture attendance and structured movements only. Four RCTs suggested qigong exercise relieved anxiety (pooled SMD = -0.75; 95% CI, -1.11 to -0.40), and three RCTs suggested that qigong exercise reduced stress (pooled SMD = -0.88; 95% CI, -1.22 to -0.55) among healthy subjects following one to three months of qigong practice, compared to wait-list controls. CONCLUSIONS: The available evidence suggests that qigong exercise reduces stress and anxiety in healthy adults. However, given the limited number of RCTs and their methodological flaws, further rigorously designed RCTs are needed.
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ItemNo Preview AvailableBeyond Professional Competence: Effect of Equanimity on the Professional Quality of Life Among Health-Care Professionals Working in Perinatal Bereavement Support(SAGE Publications, 2016-04)Health-care professionals who offer perinatal bereavement support often encountered numerous stressful events in daily practices. Secondary trauma and burnout related to psychological distress are not uncommon. Literatures suggested that further skill training enhances perceived self-competence thus lowering such traumatic impact. Nevertheless, equanimity, an emerging concept in professional development, which is characterized by a sense of unflappability and resilience in face of challenges, is an indispensable element in protecting the well-being of health-care professionals. The current study aimed to examine the role of equanimity and perceived self-competence on professional quality of life among health-care professionals. A city-wide survey study was conducted among 101 individuals who offered perinatal bereavement support at tertiary care institutions in Hong Kong. Perceived self-competence was positively associated with compassion satisfaction (β = .380, p < .001, CI = 0. 038, 0.131) and negatively correlated to burnout (β = −.439, p < .001, CI = −0.148, −0.055), in which both relationships were moderated by the level of equanimity, that is, the impact of perceived self-competence on professional quality of life was only significant among individuals with higher level of equanimity. It implied that perinatal bereavement training should integrate not only knowledge and skills but also component of equanimity training to facilitate the capacity building among frontline health-care professionals.
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ItemEpigenetic Changes in Diabetes and Cardiovascular Risk(LIPPINCOTT WILLIAMS & WILKINS, 2016-05-27)Cardiovascular complications remain the leading causes of morbidity and premature mortality in patients with diabetes mellitus. Studies in humans and preclinical models demonstrate lasting gene expression changes in the vasculopathies initiated by previous exposure to high glucose concentrations and the associated overproduction of reactive oxygen species. The molecular signatures of chromatin architectures that sensitize the genome to these and other cardiometabolic risk factors of the diabetic milieu are increasingly implicated in the biological memory underlying cardiovascular complications and now widely considered as promising therapeutic targets. Atherosclerosis is a complex heterocellular disease where the contributing cell types possess distinct epigenomes shaping diverse gene expression. Although the extent that pathological chromatin changes can be manipulated in human cardiovascular disease remains to be established, the clinical applicability of epigenetic interventions will be greatly advanced by a deeper understanding of the cell type-specific roles played by writers, erasers, and readers of chromatin modifications in the diabetic vasculature. This review details a current perspective of epigenetic mechanisms of macrovascular disease in diabetes mellitus and highlights recent key descriptions of chromatinized changes associated with persistent gene expression in endothelial, smooth muscle, and circulating immune cells relevant to atherosclerosis. Furthermore, we discuss the challenges associated with pharmacological targeting of epigenetic networks to correct abnormal or deregulated gene expression as a strategy to alleviate the clinical burden of diabetic cardiovascular disease.
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ItemThe brain is not a soap – Neurobranding for designers( 2015)Research in neuroscience shows that almost all of our thoughts and behaviours are governed subconsciously, which runs counter to the human predisposition toward reasoned decision-making. This realisation is essential to comprehending why buyers frequently spend more on branded goods than unbranded alternatives. Brands have a profound neurological impact on customer behaviour by exerting a large influence on the subconscious. I carried out an eye-tracking study to investigate how brands interact with the subconscious mind to learn more about this phenomenon. Evidence of this impact comes from the field of neuromarketing, which blends social psychology, behavioural economics, and neuroscience. In order to keep brands visible in stakeholders' minds, this field helps designers create strategic methods that closely match the identity of the customer.
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ItemNo Preview Available