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ItemFrom apology to truth? Settler colonial injustice and curricular reform in Australia since 2008Keynes, M (Taylor and Francis Group, 2024)This article explores how recent curricular reform in Australia has been responsive to a culture of redress. It argues that taken together, the 2008 National Apology to the Stolen Generations and the 2010 national curriculum reform marked a turning point, whereby settler colonial injustices have since been systematically included in the curriculum. This is explored through a case study analysis of the two iterations of the Victorian Curriculum: History post-Apology— 2012 and 2016—the latter of which remains in current use. Using discourse analysis methods, this article argues that the inclusion of colonial injustice in the post-Apology era signals a consensus that has emerged around the significance of representing injustice in history curriculum, and by extension, for shaping future citizens. Through close textual analysis of the curriculum documents, this article finds that representations of historical injustice have been organized by four frames: memorialization, equivalence, personalization, and human rights. It argues that these frames curtail opportunities for the development of an understanding of the structural character and effects of settler colonialism, and limit consideration of the longer history of Indigenous sovereignty and self-determination. These failures raise questions about how impending reforms might respond to the contemporary political context where treaty negotiations and formal truth-telling with First Nations’ polities are unfolding.
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ItemNo Preview AvailablePretty polyglot: parrotisation as the difference in repetition, againLaird, T (Unlikely, 2023)This paper was written on Kulin Country — moving between the unceded lands of the Wurundjeri, Boon Wurrung, and Dja Dja Wurrung peoples. On Kulin Country, birds are powerfully symbolic: Bunjil, the creator spirit, travels as a wedgetail eagle, and Waa, the protector, travels as a crow. Even the humble parrots, as Wurundjerri knowledge holder Mandy Nicholson reminds us, are Bunjil's children, and they carry Bunjil's messages, for those who know how to listen.
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ItemTerrestrial Lidar Reveals New Information About Habitats Provided by Large Old TreesHolland, A ; Gibbons, P ; Thompson, J ; Roudavski, S (Elsevier, 2024)Large old trees have been described as keystone habitats for several species. However, current research does not fully explain why these species show a preference for such trees. In this study, we combined field observations of birds with terrestrial lidar scans and computational feature-recognition to describe habitats provided by trees at an unprecedented level of detail. We conducted field observations of birds at 62 trees and used parameters including branch angle, branch diameter, branch state (living or dead), and trunk diameter at breast height (DBH) to develop a generalised linear mixed model (GLMM) that could predict which types of branch birds are more likely to visit. We then quantified angles, diameters, and states of 78,006 branch objects representing the complete canopies of 16 trees. By combining these two models we predicted that large trees (>80 cm DBH) contained, on average, 383 m of branches that were highly suitable for birds (i.e., the predicted probability of observing a bird was ≥0.5), which was more than seven times the average length of highly suitable branches provided by medium trees (51–80 cm DBH). Only one of the sampled medium trees contained highly suitable branches. Small trees (<50 cm DBH) contained none. Our analysis provides new knowledge about characteristics that make large old trees disproportionately attractive to birds and presents a novel method of assessment that can apply to other complex habitat structures.
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ItemNo Preview AvailableFiles, Families and the Nation: An Archival History, PerhapsSilverstein, J (ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD, 2023-10-02)
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ItemNo Preview AvailableMental Health First Aid training for China: protocol for a randomised controlled trialReavley, NJ ; Morgan, AJ ; Jorm, AF ; Kitchener, BA ; Lu, S ; Li, W ; Wang, Y ; Kelly, CM ; Zhao, M ; He, Y (ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD, 2023-01-01)
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ItemNo Preview AvailableThe gendered body during Covid-19: views from Australia, the United Kingdom, and Japan - Introduction to themed sectionWood, R ; Mccann, H (ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD, 2024-01-02)
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ItemNo Preview AvailableImmobilisation of migrant domestic worker women and their children born in LebanonBlock, K ; Fernandez, B ; McGee, T ; Al-Barazi, Z ; Brennan, D (ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD, 2024-01-01)
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ItemNo Preview AvailableA Network of Sites and Upskilled Therapists to Deliver Best-Practice Stroke Rehabilitation of the Arm: Protocol for a Knowledge Translation StudyCarey, LM ; Cahill, LS ; Blennerhassett, JM ; Nilsson, M ; Lannin, NA ; Thijs, V ; Hillier, S ; Cadilhac, DA ; Donnan, GA ; Morris, ME ; Churilov, L ; Walker, M ; Ramanathan, S ; Pollack, M ; May, E ; Cloud, GC ; Mcgowan, S ; Wijeratne, T ; Budge, M ; Mckinnon, F ; Olver, J ; Hogg, T ; Murray, M ; Haslam, B ; Koukoulas, I ; Nielsen, B ; Mak-Yuen, Y ; Turville, M ; Neilson, C ; Butler, A ; Kim, J ; Matyas, TA (MDPI, 2023-12)Implementation of evidence-informed rehabilitation of the upper limb is variable, and outcomes for stroke survivors are often suboptimal. We established a national partnership of clinicians, survivors of stroke, researchers, healthcare organizations, and policy makers to facilitate change. The objectives of this study are to increase access to best-evidence rehabilitation of the upper limb and improve outcomes for stroke survivors. This prospective pragmatic, knowledge translation study involves four new specialist therapy centers to deliver best-evidence upper-limb sensory rehabilitation (known as SENSe therapy) for survivors of stroke in the community. A knowledge-transfer intervention will be used to upskill therapists and guide implementation. Specialist centers will deliver SENSe therapy, an effective and recommended therapy, to stroke survivors in the community. Outcomes include number of successful deliveries of SENSe therapy by credentialled therapists; improved somatosensory function for stroke survivors; improved performance in self-selected activities, arm use, and quality of life; treatment fidelity and confidence to deliver therapy; and for future implementation, expert therapist effect and cost-effectiveness. In summary, we will determine the effect of a national partnership to increase access to evidence-based upper-limb sensory rehabilitation following stroke. If effective, this knowledge-transfer intervention could be used to optimize the delivery of other complex, evidence-based rehabilitation interventions.
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ItemNo Preview AvailableLevodopa Rescues Retinal Function in the Transgenic A53T Alpha-Synuclein Model of Parkinson's DiseaseTran, KKN ; Wong, VHY ; Vessey, KA ; Finkelstein, DI ; Bui, BV ; Nguyen, CTO (MDPI, 2024-01)BACKGROUND: Loss of substantia nigra dopaminergic cells and alpha-synuclein (α-syn)-rich intraneuronal deposits within the central nervous system are key hallmarks of Parkinson's disease (PD). Levodopa (L-DOPA) is the current gold-standard treatment for PD. This study aimed to evaluate in vivo retinal changes in a transgenic PD model of α-syn overexpression and the effect of acute levodopa (L-DOPA) treatment. METHODS: Anaesthetised 6-month-old mice expressing human A53T alpha-synuclein (HOM) and wildtype (WT) control littermates were intraperitoneally given 20 mg/kg L-DOPA (50 mg levodopa, 2.5 mg benserazide) or vehicle saline (n = 11-18 per group). In vivo retinal function (dark-adapted full-field ERG) and structure (optical coherence tomography, OCT) were recorded before and after drug treatment for 30 min. Ex vivo immunohistochemistry (IHC) on flat-mounted retina was conducted to assess tyrosine hydroxylase (TH) positive cell counts (n = 7-8 per group). RESULTS: We found that photoreceptor (a-wave) and bipolar cell (b-wave) ERG responses (p < 0.01) in A53T HOM mice treated with L-DOPA grew in amplitude more (47 ± 9%) than WT mice (16 ± 9%) treated with L-DOPA, which was similar to the vehicle group (A53T HOM 25 ± 9%; WT 19 ± 7%). While outer retinal thinning (outer nuclear layer, ONL, and outer plexiform layer, OPL) was confirmed in A53T HOM mice (p < 0.01), L-DOPA did not have an ameliorative effect on retinal layer thickness. These findings were observed in the absence of changes to the number of TH-positive amacrine cells across experiment groups. Acute L-DOPA treatment transiently improves visual dysfunction caused by abnormal alpha-synuclein accumulation. CONCLUSIONS: These findings deepen our understanding of dopamine and alpha-synuclein interactions in the retina and provide a high-throughput preclinical framework, primed for translation, through which novel therapeutic compounds can be objectively screened and assessed for fast-tracking PD drug discovery.
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ItemNo Preview AvailableHuman Nasal Epithelium Organoids for Assessing Neutralizing Antibodies to a Protective SARS-CoV-2 Virus-like Particle VaccineCarrera Montoya, J ; Collett, S ; Fernandez Ruiz, D ; Earnest, L ; Edeling, MA ; Yap, AHY ; Wong, CY ; Cooney, JP ; Davidson, KC ; Roberts, J ; Rockman, S ; Tran, BM ; McAuley, JL ; Deliyannis, G ; Grimley, SL ; Purcell, DFJ ; Waters, SA ; Godfrey, DI ; Hans, D ; Pellegrini, M ; Mackenzie, JM ; Vincan, E ; Heath, WR ; Torresi, J (MDPI AG, )Existing mRNA COVID-19 vaccines have shown efficacy in reducing severe cases and fatalities. However, their effectiveness against infection caused by emerging SARS-CoV-2 variants has waned considerably, necessitating the development of variant vaccines. Ideally, next-generation vaccines will be capable of eliciting broader and more sustained immune responses to effectively counteract new variants. Additionally, in vitro assays that more closely represent virus neutralization in humans would greatly assist in the analysis of protective vaccine-induced antibody responses. Here, we present findings from a SARS-CoV-2 VLP vaccine encompassing three key structural proteins: Spike (S), Envelope (E), and Membrane (M). The VLP vaccine effectively produced neutralizing antibodies as determined by surrogate virus neutralization test, and induced virus-specific T-cell responses: predominantly CD4+, although CD8+ T cell responses were detected. T cell responses were more prominent with vaccine delivered with AddaVax compared to vaccine alone. The adjuvanted vaccine was completely protective against live virus challenge in mice. Furthermore, we utilized air–liquid-interface (ALI)-differentiated human nasal epithelium (HNE) as an in vitro system, which authentically models human SARS-CoV-2 infection and neutralization. We show that immune sera from VLP-vaccinated mice completely neutralized SARS-CoV-2 virus infection, demonstrating the potential of ALI-HNE to assess vaccine induced Nab.