Minerva Elements Records
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ItemNo Preview AvailableUtility of the STOP and STOP-BANG Questionnaires in a Pre-Screened Population Presenting for Overnight Polysomnography(Sleep and Biological Rhythms, 2009)Obstructive Sleep Apnoea (OSA) is a common condition, the diagnosis of which is often delayed by prolonged waiting lists at the point of referral or in the sleep laboratory. Clinical prediction tools may become useful in triaging assessment and management of this condition. Recent publications have proposed and validated two new pre-operative screening tools for Obstructive Sleep Apnoea (OSA) in surgical patients (STOP and STOP-BANG). These screening tools have not been examined in a general sleep population. Methods: All patients attending for in-laboratory polysomnography at Box Hill Hospital during the study period were asked to complete the STOP questionnaire, and sleep scientists recorded the biometric data required for the BANG component. Polysomnography proceeded with sleep staging and event scoring performed according to the Chicago Criteria. Risk stratification by the STOP and STOP-BANG tools was combined with total Respiratory Disturbance Index from polysomnogram reports. Results: 69 patients have been recruited, although data continues to be collected. As expected, there is a predominance of moderate and severe OSA in this cohort (45/69, 65%). The STOP-BANG tool maintains higher sensitivity, negative predictive value and odds ratios than the STOP tool at each degree of OSA severity examined. Receiver operating characteristic curves demonstrate superiority of the STOP-BANG tool for RDI > 15, when compared with STOP-BANG for RDI > 30 and STOP at both RDI cut-offs. Conclusions: With ongoing data collection we hope to confirm trends seen in predictive values with these tools. Removal of less discriminatory criteria may improve their statistical usefulness, perhaps allowing development into risk stratification tools that will assist in triaging investigation and management of patients with suspected OSA.
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ItemPast Injustices and Future Protections: On the Politics of Promising(Indigenous Law Centre University of New South Wales, 2009)
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ItemArtistic practices of the Bohol School of Painting: An analytical and archival study of nineteenth-century panel paintings in the Philippines(Archetype Publishing, 2005)In the center of the Philippines on the island of Bohol, a unique panel painting practice evolved linking western artistic methods introduced by the Spanish with Filipino knowledge of materials and techniques. The scientific analysis of five nineteenth century panel paintings belonging to the Baclayon Parish was undertaken and combined with an archival investigation of the Parish Archives to develop a better understanding of their provenance. Results illustrate the western construction methods used in the panel paintings with an oil medium as well as the utilization of local materials such as Kedondong wood for the panel support, cotton and bast fiber paper for a gap filler between the wood panels, and a transparent brown hydrocarbon for the ground layer. Some of the pigments identified correlate with the geological deposits from the region and others correspond with the archival church records. Other identified pigments were not referenced in the archives or found locally. The latter indicate the importation of high quality pigments, not of Filipino origin. Further, the good condition of the panels highlight their sound preparation and an environment suited for these particular works.
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ItemNo Preview AvailableSoutheast Asian oil paintings: supports and preparatory layers(Archetype Books, 2008)
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ItemOur chemical cultural heritage: Macadam and Kirkland (1862-85)(Royal Australian Chemical Institute, 2009)In the November edition (p. 20), I provided an overview of the Chemistry Collection at the University of Melbourne, its significance and various projects I have been involved with that aim to make the collection available to the public. I hinted at how many of the items in the collection are associated with key figures in the history of chemistry and science not only at the University of Melbourne but also on national and international levels. These early teachers of chemistry are featured in an inaugural exhibition in the foyer of the Chemistry Building. Here I will focus on the early days, when chemistry was taught through the Medical School and the two main chemistry lecturers of this time: Macadam and Kirkland.
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ItemOur chemical cultural heritage: The University of Melbourne Chemistry Collection(Royal Australian Chemical Institute, 2009)The key issues covered and a description of The University of Melbourne Chemistry Collection is discussed. The collection is being temporarily housed at the university, until it is returned to its original home, The School of Chemistry.
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ItemNo Preview AvailableUtility of the stop and stop-bang questionnaires in a pre-screened population presenting for overnight polysomnography(Wiley, 2009)Obstructive Sleep Apnoea (OSA) is a common condition, the diagnosis of which is often delayed by prolonged waiting lists at the point of referral or in the sleep laboratory. Clinical prediction tools may become useful in triaging assessment and management of this condition.Recent publications have proposed and validated two new pre-opera-tive screening tools for Obstructive Sleep Apnoea (OSA) in surgical patients (STOP and STOP-BANG). These screening tools have not been examined in a general sleep population.Methods: All patients attending for in-laboratory polysomnography at Box Hill Hospital during the study period were asked to complete the STOP questionnaire, and sleep scientists recorded the biometric data required for the BANG component. Polysomnography proceeded with sleep staging and event scoring performed according to the Chicago Criteria.Risk stratification by the STOP and STOP-BANG tools was combined with total Respiratory Disturbance Index from polysomnogram reports.Results: 69 patients have been recruited, although data continues to be collected. As expected, there is a predominance of moderate and severe OSA in this cohort (45/69, 65%).The STOP-BANG tool maintains higher sensitivity, negative predic-tive value and odds ratios than the STOP tool at each degree of OSA severity examined. Receiver operating characteristic curves demonstrate superiority of the STOP-BANG tool for RDI > 15, when compared with STOP-BANG for RDI > 30 and STOP at both RDI cut-offs.Conclusions: With ongoing data collection we hope to confirm trends seen in predictive values with these tools. Removal of less discrimina-tory criteria may improve their statistical usefulness, perhaps allowing development into risk stratification tools that will assist in triaging investigation and management of patients with suspected OSA.
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ItemNo Preview AvailableIntercultural communication by non-native and native speakers of Japanese in text-based synchronous CMC.(ascilite, 2008)This study explores speech behaviour when non-native speakers of Japanese (NNSJ) and native speakers of Japanese (NSJ) exchange cultural information, specifically using text- based synchronous computer-mediated communication. This experimental study uses a scaffolding technique in which a Japanese language teacher is less present and NNSJ are left to communicate with NSJ within a restricted timeframe. This study demands their intercultural engagement, thus suggesting an outcome of intercultural relationship building. While the study examined participants’ speech behaviours – specifically, the key speech act of requesting – observed to be important for realising smooth intercultural relationships, it also highlighted attributes of available technologies useful in facilitating intercultural engagement. Since people from different cultural backgrounds have different perceptions of politeness reflected in their behaviour and language use, understanding how request strategies are used by NSJ could give NNSJ intercultural insights and skills in Japanese language and socio-cultural behaviour. CMC has been utilised in computer-assisted language learning (CALL), with students able to learn languages through a real-world context and access native speakers of the target language, beyond the classroom. CMC has been found to be an effective adopted ‘third place’ (Kramsch 1993) located at the intersection of the cultures the learner grew up with, and the cultures to which they are introduced. In the case of language use, technology allows NNSJ to record their conversations, and reflect on the language being used, thus gaining intercultural insights and skills; these could be transferable to other communication modes, whether computer-driven technology or face-to-face. It is intended that the findings of this study might shed light on the innovative enhancement of non-native Japanese speakers’ intercultural and socio-cultural competence through the use of text-based CMC.
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ItemNo Preview AvailableAgm1/Pgm-3-mediated sugar nucleotide synthesis is essential for hematopoiesis and development(AMER SOC MICROBIOLOGY, 2007-08)Carbohydrate modification of proteins includes N-linked and O-linked glycosylation, proteoglycan formation, glycosylphosphatidylinositol anchor synthesis, and O-GlcNAc modification. Each of these modifications requires the sugar nucleotide UDP-GlcNAc, which is produced via the hexosamine biosynthesis pathway. A key step in this pathway is the interconversion of GlcNAc-6-phosphate (GlcNAc-6-P) and GlcNAc-1-P, catalyzed by phosphoglucomutase 3 (Pgm3). In this paper, we describe two hypomorphic alleles of mouse Pgm3 and show there are specific physiological consequences of a graded reduction in Pgm3 activity and global UDP-GlcNAc levels. Whereas mice lacking Pgm3 die prior to implantation, animals with less severe reductions in enzyme activity are sterile, exhibit changes in pancreatic architecture, and are anemic, leukopenic, and thrombocytopenic. These phenotypes are accompanied by specific rather than wholesale changes in protein glycosylation, suggesting that while universally required, the functions of certain proteins and, as a consequence, certain cell types are especially sensitive to reductions in Pgm3 activity.
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ItemNo Preview AvailableMof (MYST1 or KAT8) is essential for progression of embryonic development past the blastocyst stage and required for normal chromatin architecture(AMER SOC MICROBIOLOGY, 2008-08)Acetylation of histone tails is a hallmark of transcriptionally active chromatin. Mof (males absent on the first; also called MYST1 or KAT8) is a member of the MYST family of histone acetyltransferases and was originally discovered as an essential component of the X chromosome dosage compensation system in Drosophila. In order to examine the role of Mof in mammals in vivo, we generated mice carrying a null mutation of the Mof gene. All Mof-deficient embryos fail to develop beyond the expanded blastocyst stage and die at implantation in vivo. Mof-deficient cell lines cannot be derived from Mof(-/-) embryos in vitro. Mof(-/-) embryos fail to acetylate histone 4 lysine 16 (H4K16) but have normal acetylation of other N-terminal histone lysine residues. Mof(-/-) cell nuclei exhibit abnormal chromatin aggregation preceding activation of caspase 3 and DNA fragmentation. We conclude that Mof is functionally nonredundant with the closely related MYST histone acetyltransferase Tip60. Our results show that Mof performs a different role in mammals from that in flies at the organism level, although the molecular function is conserved. We demonstrate that Mof is required specifically for the maintenance of H4K16 acetylation and normal chromatin architecture of all cells of early male and female embryos.