Minerva Elements Records
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ItemNo Preview AvailablePreliminary Report on the 2018-2019 Survey(Presses universitaires de Louvain, 2022-01-19)This volume, in two parts, is the fifth and last preliminary report on the excavations conducted at the Bronze Age site of Kephali tou Agiou Antoniou at Sissi in the nomos of Lasithi, Crete.
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ItemMechanisms of service ecosystem emergence: Exploring the case of public sector digital transformation(ELSEVIER SCIENCE INC, 2021-12)This research extends literature on the emergence of service ecosystems by developing new theoretical insight and explanation into how service ecosystems experience change and stability over time. Empirically, our case study focuses on digital transformation in the New Zealand public sector and the enterprise services market in 2010–2017. The exploratory and illustrative study builds on 22 in-depth interviews and extensive document analysis. We reveal three key mechanisms of service ecosystem emergence: compression, ecotonal coupling, and refraction. These mechanisms contribute to overcoming conflationary theorizing and the value of emergence in service research by establishing emergent relationality and a processual intertwining of being and becoming. These become the basis of multi-levelled, multidimensional complexity and cumulative organizing. We conclude the work by discussing the paper's contribution to service research.
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ItemPandemic racism and sexism in Australia: responses from Asian migrant women(Asia Institute, University of Melbourne, 2022)Since the COVID-19 pandemic began in December 2019, studies have emerged on its effect on either racism or sexism. Studies that address the intersection of pandemic-related racism and sexism are lacking and the experiences of Asian women have been neglected.
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ItemNo Preview AvailableWater sensitive outcomes for infill development: final report(Cooperative Research Centre for Water Sensitive Cities, 2021)Australian cities have experienced significant growth recently, a trend that is expected to continue. One response from governments has been to promote ‘infill development’, which increases urban density, but also has significant adverse effects on urban water cycles, resource use efficiency, and the amenity and liveability of urban areas.
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ItemPencil or Keyboard? Boys’ Preferences in Writing(Nova Southeastern University, 2020)Handwriting is an important subject in primary schools, especially in the Early Years. The importance of writing skill is now seen as a debate with the increasing demand on children to learn technology skills to help them with 21st Century learning—how to write on the keyboard effectively. The topic is important because handwriting is an essential life skill to have with or without technology. In this study, I looked at the importance of both in the context of the qualitative case studies in three schools in Melbourne, Australia. The aim of the research is to explore how do students understand the learning of handwriting and keyboarding in schools? This qualitative case study employed a Thematic Analysis approach in which the central intention was to understand the lived experience of six Year 6 boys across three schools and their attitudes to writing and technology. In this article, I addressed the importance of teaching handwriting to primary school students, especially in the first four years of their school life from Foundation to Year 3. The findings suggest that teachers should continue explicitly teaching handwriting to their students despite the heavy reliance on technology in today’s lifestyle.
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ItemIL-10 in glioma(Springer Nature [academic journals on nature.com], 2021-08-04)The prognosis for patients with glioblastoma (GBM), the most common and malignant type of primary brain tumour, is very poor, despite current standard treatments such as surgery, radiotherapy and chemotherapy. Moreover, the immunosuppressive tumour microenvironment hinders the development of effective immunotherapies for GBM. Cytokines such as interleukin-10 (IL-10) play a major role in modulating the activity of infiltrating immune cells and tumour cells in GBM, predominantly conferring an immunosuppressive action; however, in some circumstances, IL-10 can have an immunostimulatory effect. Elucidating the function of IL-10 in GBM is necessary to better strategise and improve the efficacy of immunotherapy. This review discusses the immunostimulatory and immunosuppressive roles of IL-10 in the GBM tumour microenvironment while considering IL-10-targeted treatment strategies. The molecular mechanisms that underlie the expression of IL-10 in various cell types are also outlined, and how this resulting information might provide an avenue for the improvement of immunotherapy in GBM is explored.
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ItemSueños náuticos en Australia (Australia's nuclear nautical dreams)(La Vanguardia, 2022-08-25)In a surprising statement with implications for nuclear weapons proliferation, Australia announced in October last year that it would pursue nuclear-powered and conventionally armed submarines. An eighteen-month study has to determine if and how the project is carried out. If it materializes, it would be done in collaboration with the United Kingdom and the United States, two traditional allies of Australia. The three countries have established the AUKUS partnership to strengthen defense and security cooperation in various areas, including, in addition to the submarine project, cyber capabilities, artificial intelligence and quantum technologies. In November 2021, the three countries signed an agreement that allows the exchange of information and visits to facilitate the study of submarines. The obstacles to Australia's submarine ambitions are legion. Among them, their astronomical costs (some estimates reach 14 billion Australian dollars per unit), Australia's limited technical capacity to build, operate, maintain and deploy such ships and the secrecy surrounding the nuclear propulsion technology that neither the UK nor the US will be willing to share with Australia. Although details are currently scarce, the most likely scenario is that Australia will try to build the submarines itself (probably eight) in the south of the country and import the nuclear reactors and highly enriched uranium fuel from the US ( UAE). The fuel would be sealed in the reactors before passing into Australian hands and returned to the US at the end of life for removal and disposal. One of the advantages of submarine reactors fueled by UAE is that they have cores that last the entire life of the submarine and do not require periodic recharging. Although there are undoubted military advantages to acquiring submarines that are quieter, can remain submerged longer, and have greater range than conventional submarines, there are also significant disadvantages.
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ItemRapture: A Study in Pathos and Scenography(International Association of Theatre Critics (IATC), 2022)This article presents Aby Warburg’s art historical approach as a potential guide for scenographic creation and analysis, forwarding Rapture as an example: a song cycle presented by Sydney Festival 2021 to a live and livestreamed audience. The author designed the set and costumes for Rapture and here reflects upon the following questions: can Warburg’s appreciation for “emotive formulas” and “engrams” assist in the making of compelling scenography when conditions for live performance are so altered from the standard? How does a design methodology championing synoptics, analytics and empathy, as Warburg did, integrate within a broader collaboration? Reconstructing Rapture’s design evolution, this study looks to the Laocoön Group, Il Medico and geometries associated with hypnosis as three persuasive pathos carriers. It finds that scenographic focus, potency and expediency arise from the proposed methodology.
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ItemNo Preview AvailableMaking robo-advisers careful? Duties of care in providing automated financial advice to consumers(ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD, 2021-01-01)
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ItemNo Preview AvailableA MXI1-NUTM1 fusion protein with MYC-like activity suggests a novel oncogenic mechanism in a subset ofNUTM1-rearranged tumors(ELSEVIER SCIENCE INC, 2021-01)Most NUTM1-rearranged neoplasms (NRNs) have fusions between NUTM1 and BRD (bromodomain-containing) family members and are termed NUT carcinomas (NCs) because they show some squamous differentiation. However, some NRNs are associated with fusions between NUTM1 and members of the MAD (MAX dimerization) gene family of MYC antagonists. Here we describe a small round cell malignancy from the gastro-esophageal junction with a previously unreported fusion between NUTM1 and the MAD family member MXI1. In contrast to NCs, the MXI1-NUTM1 tumor did not show squamous differentiation and did not express MYC, TP63 or SOX2, genes known to be targets of BRD-NUTM1 proteins and critical for NC oncogenesis. Transcriptome analysis showed paradoxical enrichment of MYC target genes in the MXI1-NUTM1 tumor despite the lack of MYC expression. When expressed in vitro MXI1-NUTM1 partially phenocopied MYC, enhancing cell proliferation and cooperating with oncogenic HRAS to produce anchorage-independent cell growth. These data provide evidence that MAD family members, which are normally repressors of MYC activity, can be converted into MYC-like mimics by fusion to NUTM1. The pathological features and novel oncogenic mechanism of the MXI1-NUTM1 tumor show that identification of NUTM1 fusion partners can be important for accurate diagnostic classification of some NRN subtypes, and potentially may guide therapeutic options.