Biomedical Engineering - Theses

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Mechanoregulatory Communication and Remodelling Networks in Cartilage Tissue Models

Boos, Manuela ( 2023-05)

The structural integrity of cartilage is vital for healthy and pain free ageing. However, it is a slow remodelling tissue and has limited healing capacity. To successfully replicate native cartilage tissue, it is crucial to understand its structure-function relationship and mechanical complexity, and to have platforms to study subsequent cellular remodelling behaviour. Therefore, this work aims to understand cartilage micromechanics by using an image-guided micromechanical evaluation approach and developing a cartilage tissue model to mimic heterogeneous mechanical domains.