Biomedical Engineering - Theses

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Subject: Microfluidics × Subject: Acoustic metasurfaces ×

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    Acoustic metasurfaces for micromanipulation
    Xu, Mingxin ( 2023-07)
    Acoustic methods are ideal tools for micromanipulation due to their biocompatibility and ability to generate acoustic fields with micro/nano-scale resolution. These methods utilize the force generated by acoustic waves to pattern, manipulate, and sort cells and microparticles without physical contact. These approaches have several advantages including the ability to handle fragile or sensitive cells without damaging them, and the potential for high-throughput manipulation of multiple cells/micro-particles simultaneously. While acoustic methods have shown great potential in micromanipulation, several challenges need to be addressed. One of the primary challenges is to generate flexible and complex acoustic fields to achieve desired manipulations, such as the trapping of cells or particles with complex patterns. Another challenge is the ability to generate programmable acoustic fields to generate instantly reconfigurable acoustic fields. Acoustic methods for micromanipulation also face challenges related to planarization and integration with other techniques. Therefore, this work introduces the following acoustic approaches based on metasurfaces for micromanipulation: (1) sawtooth acoustic metasurfaces for generating flexible acoustic fields in microfluidic channels using only a single travelling acoustic wave, (2) micropillar-based acoustic metasurfaces for applications in generating complex acoustic holographic patterns, (3) the creation of reconfigurable acoustic holograms through the modification of the sound velocity of the medium, and (4) the integration of acoustic holography with microfluidic systems to generate complex acoustic fields in microfluidic channels, where acoustic metasurfaces with subwavelength structures can achieve unique acoustic properties that do not normally exist in nature. These metasurface methods can generate flexible, complex, and programmable acoustic fields through subwavelength structures, holding great significance for various applications including acoustic tweezers, microfluidics, and biomedical sensing.