Biomedical Engineering - Theses
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ItemOptimizing Acoustic Systems for Biomedical Applications with Numerical Modeling( 2023-06)This thesis explores the development and optimization of acoustic and acoustofluidic devices. Acoustofluidic devices, which combine principles of acoustics and microfluidics, have emerged as a promising platform for biological micro-object micromanipulation due to their non-invasive, accurate, rapid, and label-free qualities. Acoustofluidic devices have found utility in various biomedical applications including single-cell studies, point-of-care testing, lab-on-a-chip studies, and tissue engineering. The objective of this thesis is to develop key components of these devices and explore new device configurations employing computational modeling and optimization techniques. As a result, novel device configurations are developed enabling complex and high-resolution micromanipulation of suspended micro-objects. In the studies presented here, computational analysis is utilized to optimize (1) traveling surface acoustic wave device dimensions, (2) the configuration of a planar acoustic resonator that integrates a structured surface, (3) the thickness of the coupling layer and superstrate materials for bulk-wave transmission, (4) the shape of acoustically-actuated 3D microstructures, and (5) waveguide topology in reusable face masks. In doing so, this work demonstrates that computational analysis is an integral part of the development of acoustofluidic devices for advanced micromanipulation and sound-transmitting structures, which have extensive potential in biomedical applications.