Engineering and Information Technology Collected Works - Research Publications

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Author: Sandberg, Claudia × End date: 2019 × Start date: 2010 × Type: Journal Article ×

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    Aqp 9 and Brain Tumour Stem Cells
    Fossdal, G ; Vik-Mo, EO ; Sandberg, C ; Varghese, M ; Kaarbo, M ; Telmo, E ; Langmoen, IA ; Murrell, W (HINDAWI LTD, 2012)
    Several studies have implicated the aquaporins (aqp) 1, 4, and 9 in the pathogenesis of malignant brain tumours, suggesting that they contribute to motility, invasiveness, and oedema formation and facilitate metabolism in tumour cells under hypoxic conditions. We have studied the expression of aqp1, 4, and 9 in biopsies from glioblastomas, isolated tumour stem cells grown in a tumoursphere assay and analyzed the progenitor and differentiated cells from these cultures. We have compared these to the situation in normal rat brain, its stem cells, and differentiated cells derived thereof. In short, qPCR in tumour tissue showed presence of aqp1, 4, and 9. In the tumour progenitor population, aqp9 was markedly more highly expressed, whilst in tumour-derived differentiated cells, aqp4 was downregulated. However, immunostaining did not reveal increased protein expression of aqp9 in the tumourspheres containing progenitor cells; in contrast, its expression (both mRNA and protein) was high in differentiated cultures. We, therefore, propose that aquaporin 9 may have a central role in the tumorigenesis of glioblastoma.
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    Hidden Treasures and Hidden Films
    Sandberg, C ; Areal Vélez, A (University of the West of England, Bristol, 2018-07-03)
    The short film Hidden Treasures/Películas Escondidas (2013) and the feature-length documentary Hidden Films. A Journey From Exile to Memory/Películas Escondidas. Un viaje entre el exilio y la memoria (2016) explore Chilean films made by the East German state-owned production company DEFA in the 1970s and 1980s as transnational memories of the Cold War. With these works, film scholar Claudia Sandberg and director Alejandro Areal Vélez highlight the importance of the East German film archives, not just as a form of political diplomacy but as a carrier of memory for quite disperse groups. Hidden Treasures and Hidden Films assess the role of filmmaking as a seismograph for larger geopolitical events and global transformations.
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