Asia Institute - Research Publications
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ItemNo Preview Available1965setiaphari (living1965)( 2015)
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ItemGenetic evidence for contribution of human dispersal to the genetic diversity of EBA-175 in Plasmodium falciparum.(Springer Science and Business Media LLC, 2015-08-01)BACKGROUND: The 175-kDa erythrocyte binding antigen (EBA-175) of Plasmodium falciparum plays a crucial role in merozoite invasion into human erythrocytes. EBA-175 is believed to have been under diversifying selection; however, there have been no studies investigating the effect of dispersal of humans out of Africa on the genetic variation of EBA-175 in P. falciparum. METHODS: The PCR-direct sequencing was performed for a part of the eba-175 gene (regions II and III) using DNA samples obtained from Thai patients infected with P. falciparum. The divergence times for the P. falciparum eba-175 alleles were estimated assuming that P. falciparum/Plasmodium reichenowi divergence occurred 6 million years ago (MYA). To examine the possibility of diversifying selection, nonsynonymous and synonymous substitution rates for Plasmodium species were also estimated. RESULTS: A total of 32 eba-175 alleles were identified from 131 Thai P. falciparum isolates. Their estimated divergence time was 0.13-0.14 MYA, before the exodus of humans from Africa. A phylogenetic tree for a large sequence dataset of P. falciparum eba-175 alleles from across the world showed the presence of a basal Asian-specific cluster for all P. falciparum sequences. A markedly more nonsynonymous substitutions than synonymous substitutions in region II in P. falciparum was also detected, but not within Plasmodium species parasitizing African apes, suggesting that diversifying selection has acted specifically on P. falciparum eba-175. CONCLUSIONS: Plasmodium falciparum eba-175 genetic diversity appeared to increase following the exodus of Asian ancestors from Africa. Diversifying selection may have played an important role in the diversification of eba-175 allelic lineages. The present results suggest that the dispersals of humans out of Africa influenced significantly the molecular evolution of P. falciparum EBA-175.
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ItemNo Preview AvailableJokowi is not fooling anyone with latest nod to victims of rights abuses(The University of Melbourne, 2015)
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ItemAustralia’s ‘Asian Century’: Time, Space and Public Culture(Japan Focus, 2015-02-10)In this essay we consider ongoing public-cultural discussions about Australia’s situation in ‘the Asian century’ as symptomatic of a conjunctural moment in Australian social life: a historical phase that is given distinctive shape by the convergence of the discourses of paranoid nationalism and free-market (inter)nationalism. We argue that the co-existence of these two (deeply contradictory) imaginaries as the dominant available rubrics for configuring ‘Australia’ and ‘Asia’ in relation to each other results in a profoundly impoverished understanding of current conditions. We propose that an account of some very differently configured relationships between ‘Asia’ and ‘Australia,’ drawn from people’s material experiences of everyday cultural life, can provide resources for those interested in thinking beyond the hyperbole of economic opportunism and the paralysis of paranoid nationalism. We begin by briefly considering ostensibly progressive innovations in governmental and public-cultural framings of the Asia-Australia relationship since the late twentieth century–– ‘Asia as market’ and ‘Asia literacy’––before turning to some stories that we argue offer much richer resources. These stories include our remembered experiences of late 20th-century Australian children’s media––always-already infused with a certain Japanese flavor. We also consider the contemporary translocal experiences of Asian Australians, Chinese international students in Australian cities, and Asian-Australian media and research collaborations. Such phenomena, we argue, constitute Australian social life as translocal and inter-cultural, thereby fundamentally challenging the presumed radical separateness of ‘Australia’ from ‘Asia’ on which currently dominant framings of Australia’s situation in the ‘Asian century’ are founded.
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ItemLimitations on religious freedom in Islam: Rethinking through the Maqasid?(Routledge - Taylor & Francis, 2015-03-16)This handbook features new, specially commissioned papers by a range of eminent scholars and offers a comprehensive overview of the field of law and religion including its historical development.
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ItemContesting Tobacco-Control Policy in Indonesia(ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD, 2015-01-02)
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ItemLaw and the Realisation of Human Rights: Insights from Indonesia's Education Sector(ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD, 2015-04-03)
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ItemRealising Rights in Low Quality Democracies: Instructive Asian Cases(ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD, 2015-04-03)
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ItemNo Preview AvailableCan a modern system of governance work under Xi?(Nikkei Inc, 2015-10-31)
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ItemBibliography of the Languages of Borneo (and Madagascar)(KITLV PRESS, 2015-01-01)