Asia Institute - Research Publications

Permanent URI for this collection

http://hdl.handle.net/11343/401

Filters

2020 2
Reset filters

Settings
Statistics
Citations
Author: Ohashi, Jun × Type: Journal Article × Start date: 2020 × End date: 2020 ×

Search Results

Now showing 1 - 2 of 2
  • Item
    Thumbnail Image
    Genome-wide association study identifies CDH13 as a susceptibility gene for rhododendrol-induced leukoderma.
    Okamura, K ; Abe, Y ; Naka, I ; Ohashi, J ; Yagami, A ; Matsunaga, K ; Kobayashi, Y ; Fukai, K ; Tanemura, A ; Katayama, I ; Masui, Y ; Ito, A ; Yamashita, T ; Nagai, H ; Nishigori, C ; Oiso, N ; Aoyama, Y ; Araki, Y ; Saito, T ; Hayashi, M ; Hozumi, Y ; Suzuki, T (Wiley, 2020-11)
    Racemic RS-4-(4-hydroxyphenyl)-2-butanol (rhododendrol; trade name: Rhododenol [RD]), which is used in topical skin-lightening cosmetics, was unexpectedly reported in Japan to induce leukoderma or vitiligo called RD-induced leukoderma (RIL) after repeated application. To our knowledge, no studies have investigated chemical-induced vitiligo pathogenesis on a genome-wide scale. Here, we conducted a genome-wide association study (GWAS) for 147 cases and 112 controls. CDH13, encoding a glycosylphosphatidylinositol-anchored protein called T-cadherin (T-cad), was identified as the strongest RIL susceptibility gene. RD sensitivity was remarkably increased by T-cad knockdown in cultured normal human melanocytes. Furthermore, we confirmed tyrosinase upregulation and downregulation of the anti-apoptotic molecules (BCL-2 and BCL-XL), suggesting that T-cad is associated with RD via tyrosinase or apoptotic pathway regulation. Finally, monobenzyl ether of hydroquinone sensitivity also tended to increase with T-cad knockdown, suggesting that the T-cad could be a candidate susceptibility gene for RIL and other chemical-induced vitiligo forms. This is the first GWAS for chemical-induced vitiligo, and it could be a useful model for studying the disease's genetic aspects.
  • Item
    Thumbnail Image
    The Nation over Gender and Class: Media Framing of Comfort Women in South Korea and Japan
    Song, J ; Ohashi, J (The British Association for Korean Studies, 2020-10-01)
    In December 2015, South Korea and Japan reached an agreement on resolving the “comfort women” issue that sparked media interests. This article analyses how the South Korean and Japanese media covered comfort women in 2013–2018. The study collects over 20,000 newspaper articles and analyses distinctive media framings in liberal, conservative and leftist newspapers in South Korea and Japan. During this period, the South Korean media have gone beyond the extant nationalist and feminist narratives and incorporated a class dimension. The authors find that there have been dynamic interplays among nation, gender and class that make the debates more complex and transnational, yet the dominant narratives are still from liberal or leftist nationalists in Korea and conservative statists in Japan.