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ItemGrammar notes on Siraya, an extinct Formosan language(University of Hawaii Press, 1997-12-01)This is an attempt to unravel the grammar of a gospel text in Siraya, an extinct West Formosan language. It includes a discussion of the historical setting, the spelling, phonological features, function words, relation markers, morphosyntax of the verb, and the use of deictic verbs as prepositions. Regarding verbal morphosyntax, special attention is given to case marking suffixes, verbal classifiers, compound verbs, and anticipating sequences. Verbal classifiers are lexical elements prefixed to a root (a verb, adverb, or noun) with which they constitute the overall meaning of the resulting verb (mattäy- ‘talking, saying’ + vli ‘reciprocating, doing in return’ mattäy-vli ‘to answer’; mattäy- + rĭx ‘mind’ mattäy- rĭx ‘talk to oneself’). Compound verb constructions are constructions in which auxiliaries assume the functions of adverbs in English. These auxiliaries form an open class and are in fact the head of the verb phrase, as they carry most of the marking. An anticipating sequence is an element of a verb that is prefixed to the preceding auxiliary.
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ItemSiraya reduplication (West Formosa, roots, lexical properties of wordbases, disyllabic reduplication)(University of Hawaii Press, 2000-06-01)The main patterns of reduplication in Siraya (West Formosa) include monosyllabic root reduplication, an inherent lexical property of certain wordbases, and disyllabic reduplication, which adds the notion of diffuseness (including plurality, variety, similarity) to nominal wordbases, and the notion of diffusenes (repetition of action, plurality of actants) or continuity (including state, process) to verbal wordbases. The same meanings are conveyed by rightward reduplication, which applies when the last three or four segments of a root are copied at the end (losing the final consonant if there is one). First-syllable reduplication basically forms cardinal numbers with nonhuman referents. Ca- reduplication is part of verbal morphosyntax indicating progressive aspect, generic aspect, or a state, but it also forms deverbal nouns; it is, moreover, used with ordinal numerals, and with cardinal numerals and other count words having a human referent. Contrary to the general pattern found in other Austronesian languages (Blust 1998), the meaning of Siraya nouns derived through Ca- reduplication is not restricted to that of instrument but also includes that of agent, abstract noun, undergoer, and (in combination with the suffix -an) location. Finally, pa- reduplication is a morphosyntactic device forming causative verbs.
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ItemNatural Conversation Reconstruction Tasks: The Language Classroom as a Meeting Place(University of Technology, Sydney (UTS), 2009)This paper, drawing on Pratt’s notion of ‘transculturation’ and Bhabha’s ‘third space’, presents an example of language learning tasks that empower learners’ agency and promote their cross-cultural awareness and sensitivities to a different set of cultural expectations, using a naturally occurred Japanese thanking episodes. The paper discusses the merits of Natural Conversation Reconstruction Tasks (NCRTs) as a practical method for helping L2 learners develop this ‘intercultural competence’. It is based on a qualitative study of the results of one NCRT created for use in the context of teaching Japanese as a L2 in a multicultural society. It suggests the NCRT encourages the learners to explore the intersection where language use, speaker intention and L1 and L2 cultural norms meet. Such a process helps the learners become aware of socially expected patterns of communication in L1 and L2 in terms of the choices of speech act, formulaic expressions, sequential organization and politeness orientation. The learners’ comments suggest that the NCRT helps learners transcend their cultural boundaries by overcoming their narrow understanding of ‘thanking’ as ‘expressions of gratitude and appreciation’ and by cross-culturally widening their views of what counts as thanking. The NCRT with rich contextual information promotes the learners’ intercultural awareness, sensitivity to context and intercultural exploration in the space between L1 and L2, where they have authority and freedom of making sense of conversations, and pragmatics is fully integrated into language pedagogy.
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ItemThe Fragmented Self: Cross-cultural Difference, Conflict and the Lessons of Ethnographic Experience(Frobenius Institute, 2006)
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ItemArriving in the Future: The Utopia of Here and Now in the Work of Modern-Day Mystics From Eric Fromm to Eckhart Tolle(MONASH UNIV, CENTRE COMPARATIVE LITERATURE & CULTURAL STUDIES, 2009-12-01)
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ItemNo Preview AvailableACE1 polymorphism and progression of SARS.(Elsevier BV, 2004-10-22)We have hypothesized that genetic predisposition influences the progression of SARS. Angiotensin converting enzyme (ACE1) insertion/deletion (I/D) polymorphism was previously reported to show association with the adult respiratory distress syndrome, which is also thought to play a key role in damaging the lung tissues in SARS cases. This time, the polymorphism was genotyped in 44 Vietnamese SARS cases, with 103 healthy controls who had had a contact with the SARS patients and 50 controls without any contact history. SARS cases were divided into either non-hypoxemic or hypoxemic groups. Despite the small sample size, the frequency of the D allele was significantly higher in the hypoxemic group than in the non-hypoxemic group (p=0.013), whereas there was no significant difference between the SARS cases and controls, irrespective of a contact history. ACE1 might be one of the candidate genes that influence the progression of pneumonia in SARS.
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ItemNo Preview AvailablePolymorphisms of human leucocyte antigen genes in Maonan people in China.(Wiley, 2007-02)We examined human leucocyte antigen (HLA) gene polymorphisms in the Maonan people from southern China. HLA-A, -B and -DRB1 alleles were determined in 108 healthy unrelated Maonan individuals by the polymerase chain reaction-Luminex method, and haplotype frequencies for HLA-A, -B and -DRB1 loci were estimated. The most frequent HLA-A alleles were A*1101 (35.2%), A*0203 (17.6%), A*0207 (13.4%) and A*2402 (13.4%); HLA-B alleles were B*1301(19.9%), B*1502 (14.8%), B*4601 (13.4%) and B*4001 (13.4%); HLA-DRB1 alleles were DRB1*1202 (17.1%), DRB1*1602 (13.0%) and DRB1*1401 (10.7%). The most common haplotypes were A*0207-B*4601 (10.6%), A*1101-B*1301 (10.0%), A*1101-B*4001 (8.4%), B*1502-DRB1*1202 (12.0%), B*4601-DRB1*1401 (5.8%), A*1101-B*1502-DRB1*1202 (7.1%) and A*0207-B*4601-DRB1*1401 (5.3%), profiles that are also found in populations from the southern region of East Asia. Phylogenetic and principal component analyses revealed that the Maonan people belong to the southeastern Asian group and are most closely related to the Buyi people.
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ItemA replication study of the association between the IL12B promoter allele CTCTAA and susceptibility to cerebral malaria in Thai population.(Springer Science and Business Media LLC, 2009-12-11)BACKGROUND: Interleukin-12 (IL-12), a heterodimeric cytokine composed of p35 and p40 subunits, has been thought to play an important role in the pathogenesis of malaria. The IL-12p40 subunit is encoded by the IL12B gene. An IL12B promoter allele, CTCTAA, at rs17860508 has been reported to be associated with susceptibility to cerebral malaria in African populations. However, this association has not so far been replicated in non-African populations. METHODS: To examine whether the CTCTAA allele is associated with susceptibility to cerebral malaria in Asian populations, 303 Thai patients with Plasmodium falciparum malaria (109 cerebral malaria and 194 mild malaria patients) were genotyped for rs17860508 by PCR-direct sequencing. RESULTS: The CTCTAA allele showed a significant association with susceptibility to cerebral malaria in the Thai population (allelic OR = 1.37; one sided P-value = 0.030). CONCLUSIONS: The existence of a significant association between the CTCTAA allele and susceptibility to cerebral malaria was confirmed in Southeast Asian population, which was previously reported in African populations.
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ItemIdentification of a haplotype block in the 5q31 cytokine gene cluster associated with the susceptibility to severe malaria.(Springer Science and Business Media LLC, 2009-10-19)BACKGROUND: It has been previously demonstrated that a single nucleotide polymorphism (SNP) in the IL13 promoter region, IL13 -1055T>C (rs1800925), was associated with susceptibility to severe malaria in Thais. In the present study, fine association mapping for a cytokine gene cluster including IL4, IL5, and IL13 on chromosome 5q31 was conducted using the same malaria subjects to refine the region containing a primary variant or a haplotype susceptible to severe malaria. METHODS: A total of 82 SNPs spanning 522 kb of the 5q31 region were analysed in 368 patients with Plasmodium falciparum malaria (203 mild malaria and 165 severe malaria patients). RESULTS: Only rs1881457 located in the promoter region of IL13, which is in linkage disequilibrium with rs1800925 (r2 = 0.73), showed a significant association with severe malaria after adjusting for multiple testing (P = 0.046 by permutation test). This SNP was in a haplotype block spanning 97 kb (from rs2069812 to rs2240032). The detected haplotype block contained the RAD50 gene and the promoter of IL13, but not the other genes. CONCLUSION: A haplotype block in which a primary polymorphism associated with severe malaria is likely to be encoded was identified in Thai malaria patients.
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ItemPopulation diversity and antibody selective pressure to Plasmodium falciparum MSP1 block2 locus in an African malaria-endemic setting.(Springer Science and Business Media LLC, 2009-10-15)BACKGROUND: Genetic evidence for diversifying selection identified the Merozoite Surface Protein1 block2 (PfMSP1 block2) as a putative target of protective immunity against Plasmodium falciparum. The locus displays three family types and one recombinant type, each with multiple allelic forms differing by single nucleotide polymorphism as well as sequence, copy number and arrangement variation of three amino acid repeats. The family-specific antibody responses observed in endemic settings support immune selection operating at the family level. However, the factors contributing to the large intra-family allelic diversity remain unclear. To address this question, population allelic polymorphism and sequence variant-specific antibody responses were studied in a single Senegalese rural community where malaria transmission is intense and perennial. RESULTS: Family distribution showed no significant temporal fluctuation over the 10 y period surveyed. Sequencing of 358 PCR fragments identified 126 distinct alleles, including numerous novel alleles in each family and multiple novel alleles of recombinant types. The parasite population consisted in a large number of low frequency alleles, alongside one high-frequency and three intermediate frequency alleles. Population diversity tests supported positive selection at the family level, but showed no significant departure from neutrality when considering intra-family allelic sequence diversity and all families combined. Seroprevalence, analysed using biotinylated peptides displaying numerous sequence variants, was moderate and increased with age. Reactivity profiles were individual-specific, mapped to the family-specific flanking regions and to repeat sequences shared by numerous allelic forms within a family type. Seroreactivity to K1-, Mad20- and R033 families correlated with the relative family genotype distribution within the village. Antibody specificity remained unchanged with cumulated exposure to an increasingly large number of alleles. CONCLUSION: The Pfmsp1 block2 locus presents a very large population sequence diversity. The lack of stable acquisition of novel antibody specificities despite exposure to novel allelic forms is reminiscent of clonal imprinting. The locus appears under antibody-mediated diversifying selection in a variable environment that maintains a balance between the various family types without selecting for sequence variant allelic forms. There is no evidence of positive selection for intra-family sequence diversity, consistent with the observed characteristics of the antibody response.