Asia Institute - Research Publications

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    Polymorphisms of human leucocyte antigen genes in Maonan people in China.
    Ogata, S ; Shi, L ; Matsushita, M ; Yu, L ; Huang, XQ ; Shi, L ; Sun, H ; Ohashi, J ; Muramatsu, M ; Tokunaga, K ; Chu, JY (Wiley, 2007-02)
    We examined human leucocyte antigen (HLA) gene polymorphisms in the Maonan people from southern China. HLA-A, -B and -DRB1 alleles were determined in 108 healthy unrelated Maonan individuals by the polymerase chain reaction-Luminex method, and haplotype frequencies for HLA-A, -B and -DRB1 loci were estimated. The most frequent HLA-A alleles were A*1101 (35.2%), A*0203 (17.6%), A*0207 (13.4%) and A*2402 (13.4%); HLA-B alleles were B*1301(19.9%), B*1502 (14.8%), B*4601 (13.4%) and B*4001 (13.4%); HLA-DRB1 alleles were DRB1*1202 (17.1%), DRB1*1602 (13.0%) and DRB1*1401 (10.7%). The most common haplotypes were A*0207-B*4601 (10.6%), A*1101-B*1301 (10.0%), A*1101-B*4001 (8.4%), B*1502-DRB1*1202 (12.0%), B*4601-DRB1*1401 (5.8%), A*1101-B*1502-DRB1*1202 (7.1%) and A*0207-B*4601-DRB1*1401 (5.3%), profiles that are also found in populations from the southern region of East Asia. Phylogenetic and principal component analyses revealed that the Maonan people belong to the southeastern Asian group and are most closely related to the Buyi people.
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    A practical genome scan for population-specific strong selective sweeps that have reached fixation.
    Kimura, R ; Fujimoto, A ; Tokunaga, K ; Ohashi, J ; Harpending, H (Public Library of Science (PLoS), 2007-03-14)
    Phenotypic divergences between modern human populations have developed as a result of genetic adaptation to local environments over the past 100,000 years. To identify genes involved in population-specific phenotypes, it is necessary to detect signatures of recent positive selection in the human genome. Although detection of elongated linkage disequilibrium (LD) has been a powerful tool in the field of evolutionary genetics, current LD-based approaches are not applicable to already fixed loci. Here, we report a method of scanning for population-specific strong selective sweeps that have reached fixation. In this method, genome-wide SNP data is used to analyze differences in the haplotype frequency, nucleotide diversity, and LD between populations, using the ratio of haplotype homozygosity between populations. To estimate the detection power of the statistics used in this study, we performed computer simulations and found that these tests are relatively robust against the density of typed SNPs and demographic parameters if the advantageous allele has reached fixation. Therefore, we could determine the threshold for maintaining high detection power, regardless of SNP density and demographic history. When this method was applied to the HapMap data, it was able to identify the candidates of population-specific strong selective sweeps more efficiently than the outlier approach that depends on the empirical distribution. This study, confirming strong positive selection on genes previously reported to be associated with specific phenotypes, also identifies other candidates that are likely to contribute to phenotypic differences between human populations.
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    Pacific: Japan, Australia, New Zealand
    Oishi, N ; Waters, MC ; Ueda, R (Harvard University Press, 2007)
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    "Two in one": exploring cross-cultural concepts and realities about relationships
    Wejak, Justin L. (The Australian Indonesian Association of Victoria Inc., 2005-10)
    This article explores cross-cultural concepts and realities about relationships, in a particular context of Indonesia.
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    Online intimacy in a Chinese setting
    McLaren, AE (Informa UK Limited, 2007-01-01)
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    Malayo-Sumbawan
    Adelaar, A (UNIV HAWAII PRESS, 2005-12-01)