Asia Institute - Research Publications

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Type: Journal Article × Start date: 2008 × End date: 2008 ×

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    Role of STAT4 polymorphisms in systemic lupus erythematosus in a Japanese population: a case-control association study of the STAT1-STAT4 region.
    Kawasaki, A ; Ito, I ; Hikami, K ; Ohashi, J ; Hayashi, T ; Goto, D ; Matsumoto, I ; Ito, S ; Tsutsumi, A ; Koga, M ; Arinami, T ; Graham, RR ; Hom, G ; Takasaki, Y ; Hashimoto, H ; Behrens, TW ; Sumida, T ; Tsuchiya, N (Springer Science and Business Media LLC, 2008)
    INTRODUCTION: Recent studies identified STAT4 (signal transducers and activators of transcription-4) as a susceptibility gene for systemic lupus erythematosus (SLE). STAT1 is encoded adjacently to STAT4 on 2q32.2-q32.3, upregulated in peripheral blood mononuclear cells from SLE patients, and functionally relevant to SLE. This study was conducted to test whether STAT4 is associated with SLE in a Japanese population also, to identify the risk haplotype, and to examine the potential genetic contribution of STAT1. To accomplish these aims, we carried out a comprehensive association analysis of 52 tag single nucleotide polymorphisms (SNPs) encompassing the STAT1-STAT4 region. METHODS: In the first screening, 52 tag SNPs were selected based on HapMap Phase II JPT (Japanese in Tokyo, Japan) data, and case-control association analysis was carried out on 105 Japanese female patients with SLE and 102 female controls. For associated SNPs, additional cases and controls were genotyped and association was analyzed using 308 SLE patients and 306 controls. Estimation of haplotype frequencies and an association study using the permutation test were performed with Haploview version 4.0 software. Population attributable risk percentage was estimated to compare the epidemiological significance of the risk genotype among populations. RESULTS: In the first screening, rs7574865, rs11889341, and rs10168266 in STAT4 were most significantly associated (P < 0.01). Significant association was not observed for STAT1. Subsequent association studies of the three SNPs using 308 SLE patients and 306 controls confirmed a strong association of the rs7574865T allele (SLE patients: 46.3%, controls: 33.5%, P = 4.9 x 10(-6), odds ratio 1.71) as well as TTT haplotype (rs10168266/rs11889341/rs7574865) (P = 1.5 x 10(-6)). The association was stronger in subgroups of SLE with nephritis and anti-double-stranded DNA antibodies. Population attributable risk percentage was estimated to be higher in the Japanese population (40.2%) than in Americans of European descent (19.5%). CONCLUSIONS: The same STAT4 risk allele is associated with SLE in Caucasian and Japanese populations. Evidence for a role of STAT1 in genetic susceptibility to SLE was not detected. The contribution of STAT4 for the genetic background of SLE may be greater in the Japanese population than in Americans of European descent.
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    Rewriting Trauma ― The 228 Incident and Li Ang’s “Rouged Sacrifice”
    CraigSmith, (Chinese Literary Society, 2008-03)
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    Taiwan’s 228 Incident and the Politics of Placing Blame
    Smith, C (University of Alberta, 2008)
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    Some reflections on the Contextualist approach to ethico-legal texts of the Quran
    Saeed, A (CAMBRIDGE UNIV PRESS, 2008-01-01)
    Abstract A “contextualist” reading of the Quran is becoming increasingly popular, particularly among those Muslims referred to as “progressive-ijtihadis”. One of the primary concerns of this reading is that in order to understand and interpret the ethico-legal content of the Quran and relate that content to the changing needs and circumstances of Muslims today, it is important to approach the text at different levels, giving a high degree of emphasis to the socio-historical context of the text. In the classical tafsīr this emphasis on socio-historical context was not considered important, particularly in the interpretation of the ethico-legal texts, despite the frequent use of asbāb al-nuzūl literature. In this paper, I will explore how progressive-ijtihadis are adopting a contextualist reading of ethico-legal texts of the Quran. To illustrate this, I will use one or two such texts (verses) and their interpretations by the progressive-ijtihadis and will seek to demonstrate the contours of this approach, and highlight some of the challenges this approach is facing.
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    Prospects for feminism in the Islamic republic of Iran
    Barlow, R ; Akbarzadeh, S (JOHNS HOPKINS UNIV PRESS, 2008-02-01)
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    Intertext and Allusion in the Quranic Presentation of the Story of Noah
    ABDULLAH, A (The International Institute of Islamic Thought, 2008)
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    Linguistic rituals for thanking in Japanese: Balancing obligations
    Ohashi, J (ELSEVIER SCIENCE BV, 2008-12-01)