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ItemPrinciples for open access to research outputs at Melbourne( 2019)In Australia, the 2017 Policy Statement on F.A.I.R. Access to Australia’s Research Outputs was released, endorsed by Universities Australia. The University of Melbourne supports this policy statement through the adoption of Principles for Open Access to Research Outputs at Melbourne. These principles signal that the University of Melbourne is committed to disseminating its research as widely as possible to improve the public good by accelerating the pace of discovery, encouraging innovation, enriching education, and stimulating the economy. The University supports the deposit of research outputs to repositories as a means of openly disseminating research and publication in open access journals. (Minor revisions were approved by University Executive on 22 April 2020)
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ItemCultivating capability The socio-technical challenges of integrating approaches to records and knowledge management(EMERALD GROUP PUBLISHING LTD, 2016-01-01)Purpose This paper aims to advocate that significant human and systems-based capabilities (termed “socio-technical capabilities”) need to be developed in government departments and other public sector organisations to support more effective description of information resources, collections and their context in online environments. Design/methodology/approach The ideas in this paper draw upon the findings of several action research interventions undertaken within a government department in Victoria in Australia since 2011 as part of a knowledge management initiative. Specific focus is given to the design and development of a new record-centric knowledge curation tool (KCT). Findings Effective functioning of KCT relies upon the input of well-structured, standards-based metadata used to describe collections, information resources and their context. The central claim is that the move towards standards-based descriptions will fundamentally change the capabilities required to manage, search for and disseminate knowledge and records. Research limitations/implications In addition to the capabilities discussed, management of records and knowledge through time requires commitments to stable repository, workflow and administrative systems, and working with contemporary systems involves technical knowledge such as the use of application programming interfaces. These aspects are not discussed here. Practical implications The capabilities discussed in this paper are socio-technical in nature. This means there is a requirement to shift current perspectives about who is responsible for managing organisational information as collections. Originality/value While some of the concepts discussed will be familiar to information professionals, the paper provides a unique description of how existing archival and recordkeeping practices are being integrated in innovative ways within organisations outside the information management professions.
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ItemSubstrate Depth, Vegetation and Irrigation Affect Green Roof Thermal Performance in a Mediterranean Type Climate(MDPI, 2017-08-01)Green roofs are consistently being used to reduce some of the negative environmental impacts of cities. The increasing interest in extensive green roofs requires refined studies on their design and operation, and on the effects of their relevant parameters on green roof thermal performance. The effects of two design parameters, substrate thickness (ST) and conductivity of dry soil (CDS), and four operating parameters, leaf area index (LAI), leaf reflectivity (LR), stomatal resistance (SR), and moisture content (MC), were investigated using the green roof computer model developed by Sailor in 2008. The computer simulations showed that among the operating parameters, LAI has the largest effects on thermal performance while CDS is a more influential design parameter than ST. Experimental investigations of non-vegetated and sparsely vegetated green roofs in Melbourne were principally used to understand the effect of the substrate and enable better understanding of dominant heat transfer mechanisms involved. Investigated green roofs had three substrate thicknesses (100, 150 and 200 mm), and their performance was compared to a bare conventional roof. In contrast to the computer simulations, the experimental results for summer and winter showed the importance of MC and ST in reducing the substrate temperature and heat flux through the green roof.
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ItemMeasuring the impact: Springer Book Archives at Melbourne(Neal-Schuman Publishers, 2017)Purpose: The purpose of this paper is to examine usage trends during the first four years of the implementation of the Springer Book Archives (SBA) at the University of Melbourne. The article assesses the benefits of the SBA against perceptions at the time of purchase and seeks to evaluate the long term value of the purchase. Design/methodology/approach: The methodology included a literature search to identify issues in the adoption of large backlists of ebooks, examination of detailed usage data supplied in COUNTER complaint spreadsheets and tables by Springer, validating findings with librarians and academics and positing next steps. Findings: Usage of ebooks, like other electronic resources is difficult to predict. Resources expected to be used, may not be and vice versa. Access to large aggregations of electronic content creates new opportunities for teaching and research, additional economies and benefits as well as unexpected outcomes. Research limitations: Detailed data on user profiles was not available and an evaluation of user perceptions was not possible at this time. Originality/value: The literature review suggests that this is the only published study of institutional usage of the Springer book archives at this time.
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ItemNo Preview AvailableGenetics of epilepsy The testimony of twins in the molecular era(LIPPINCOTT WILLIAMS & WILKINS, 2014-09-16)OBJECTIVE: Analysis of twins with epilepsy to explore the genetic architecture of specific epilepsies, to evaluate the applicability of the 2010 International League Against Epilepsy (ILAE) organization of epilepsy syndromes, and to integrate molecular genetics with phenotypic analyses. METHODS: A total of 558 twin pairs suspected to have epilepsy were ascertained from twin registries (69%) or referral (31%). Casewise concordance estimates were calculated for epilepsy syndromes. Epilepsies were then grouped according to the 2010 ILAE organizational scheme. Molecular genetic information was utilized where applicable. RESULTS: Of 558 twin pairs, 418 had confirmed seizures. A total of 534 twin individuals were affected. There were higher twin concordance estimates for monozygotic (MZ) than for dizygotic (DZ) twins for idiopathic generalized epilepsies (MZ = 0.77; DZ = 0.35), genetic epilepsy with febrile seizures plus (MZ = 0.85; DZ = 0.25), and focal epilepsies (MZ = 0.40; DZ = 0.03). Utilizing the 2010 ILAE scheme, the twin data clearly demonstrated genetic influences in the syndromes designated as genetic. Of the 384 tested twin individuals, 10.9% had mutations of large effect in known epilepsy genes or carried validated susceptibility alleles. CONCLUSIONS: Twin studies confirm clear genetic influences for specific epilepsies. Analysis of the twin sample using the 2010 ILAE scheme strongly supported the validity of grouping the "genetic" syndromes together and shows this organizational scheme to be a more flexible and biologically meaningful system than previous classifications. Successful selected molecular testing applied to this cohort is the prelude to future large-scale next-generation sequencing of epilepsy research cohorts. Insights into genetic architecture provided by twin studies provide essential data for optimizing such approaches.
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ItemNo Preview AvailableRotavirus inhibits IFN-induced STAT nuclear translocation by a mechanism that acts after STAT binding to importin-alpha(SOC GENERAL MICROBIOLOGY, 2014-08-01)The importance of innate immunity to rotaviruses is exemplified by the range of strategies evolved by rotaviruses to interfere with the IFN response. We showed previously that rotaviruses block gene expression induced by type I and II IFNs, through a mechanism allowing activation of signal transducer and activator of transcription (STAT) 1 and STAT2 but preventing their nuclear accumulation. This normally occurs through activated STAT1/2 dimerization, enabling an interaction with importin α5 that mediates transport into the nucleus. In rotavirus-infected cells, STAT1/2 inhibition may limit the antiviral actions of IFN produced early in infection. Here we further analysed the block to STAT1/2 nuclear accumulation, showing that activated STAT1 accumulates in the cytoplasm in rotavirus-infected cells. STAT1/2 nuclear accumulation was inhibited by rotavirus even in the presence of the nuclear export inhibitor Leptomycin B, demonstrating that enhanced nuclear export is not involved in STAT1/2 cytoplasmic retention. The ability to inhibit STAT nuclear translocation was completely conserved amongst the group A rotaviruses tested, including a divergent avian strain. Analysis of mutant rotaviruses indicated that residues after amino acid 47 of NSP1 are dispensable for STAT inhibition. Furthermore, expression of any of the 12 Rhesus monkey rotavirus proteins did not inhibit IFN-stimulated STAT1 nuclear translocation. Finally, co-immunoprecipitation experiments from transfected epithelial cells showed that STAT1/2 binds importin α5 normally following rotavirus infection. These findings demonstrate that rotavirus probably employs a novel strategy to inhibit IFN-induced STAT signalling, which acts after STAT activation and binding to the nuclear import machinery.
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ItemRegional Trade Agreements and Regionalisation: Motivations and limits of a global phenomenon.(Australian National University, 2013)
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ItemThe evolving geography of production hubs and regional value chains across East Asia: Trade in value-added(ELSEVIER SCIENCE INC, 2015-07-01)The interdependence of regional trade and production networks has important implications for national prosperity, regional stability and the internationalization of production. We ask: What are the locational patterns of trade in value-added in East Asia and how are these patterns changing over time? The disintermediation of value chains and the externalization of business activity create hubs of capability and extend value chains between countries. We adopt input-output techniques to analyze the evolution of production networks in East Asia over the period 1990-2005 from a value chain perspective. A high density of cross-border interaction is reported alongside changing geographic dynamics, and an informal integration derived from intermediates trade in value-addition. The locational interdependence of developed and less-developed countries across the region leverages on the heterogeneity of location-specific advantages within the region.
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ItemNegotiating the Transatlantic Relationship: An International, Interdisciplinary Simulation of a Real-World Negotiation(CAMBRIDGE UNIV PRESS, 2016-04-01)This article analyzes the effectiveness of an international, interdisciplinary simulation of an ongoing trade negotiation. It thoroughly describes the simulation, provides links to background information for public use, and off ers suggestions on ways to further strengthen the learning outcomes achieved.
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ItemPerspectives on strategic internationalization: Developing capabilities for renewal(ELSEVIER SCIENCE BV, 2016-08-01)While strategic renewal has increasingly received interest from strategy scholars (Agarwal & Helfat, 2009; Baden-Fuller & Volberda, 1997; Capron & Mitchell, 2009; Crossan & Berdrow, 2003; Gulati & Puranam, 2009; Huff, Huff, & Thomas, 1992), its gains from internationalization are less understood. We draw on both internationalization and strategy literature to investigate what is known about 'if' and 'how' firms renew their capabilities through internationalization. We anticipate that the scope of internationalization has an inverted U-shape effect on the firm's ability to create alternatives for renewal, thus allowing for the development of renewal capabilities. Yet we also draw attention to the factors that may represent limitations of the role of internationalization for strategic renewal. Internationalization strategies related to location, timing and venture mode decisions are antecedents to capability renewal strategies, uncovered as linear vs. non-linear renewal paths.