- Chemical and Biomolecular Engineering - Research Publications
Chemical and Biomolecular Engineering - Research Publications
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ItemPhotocontrolled Cargo Release from Dual Cross-Linked Polymer ParticlesTan, S ; Cui, J ; Fu, Q ; Nam, E ; Ladewig, K ; Ren, JM ; Wong, EHH ; Caruso, F ; Blencowe, A ; Qiao, GG (AMER CHEMICAL SOC, 2016-03-09)Burst release of a payload from polymeric particles upon photoirradiation was engineered by altering the cross-linking density. This was achieved via a dual cross-linking concept whereby noncovalent cross-linking was provided by cyclodextrin host-guest interactions, and irreversible covalent cross-linking was mediated by continuous assembly of polymers (CAP). The dual cross-linked particles (DCPs) were efficiently infiltrated (∼80-93%) by the biomacromolecule dextran (molecular weight up to 500 kDa) to provide high loadings (70-75%). Upon short exposure (5 s) to UV light, the noncovalent cross-links were disrupted resulting in increased permeability and burst release of the cargo (50 mol % within 1 s) as visualized by time-lapse fluorescence microscopy. As sunlight contains UV light at low intensities, the particles can potentially be incorporated into systems used in agriculture, environmental control, and food packaging, whereby sunlight could control the release of nutrients and antimicrobial agents.
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ItemFabrication of ultra-thin polyrotaxane-based films via solid-state continuous assembly of polymersTan, S ; Nam, E ; Cui, J ; Xu, C ; Fu, Q ; Ren, JM ; Wong, EHH ; Ladewig, K ; Caruso, F ; Blencowe, A ; Qiao, GG (ROYAL SOC CHEMISTRY, 2015)Surface-confined ultra-thin polyrotaxane (PRX)-based films with tunable composition, surface topology and swelling characteristics were prepared by solid-state continuous assembly of polymers (ssCAP). The PRX-based films supported cell attachment, and their degradation in biological media could be tuned. This study provides a versatile nano-coating technology with potential applications in biomedicine, including tissue engineering and medical devices.