Chemical and Biomolecular Engineering - Research Publications

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Templated synthesis of single-component polymer capsules and their application in drug delivery

Wang, Y ; Bansal, V ; Zelikin, AN ; Caruso, F (AMER CHEMICAL SOC, 2008-06)

We report a general and facile approach for the fabrication of a new class of monodispersed, single-component and thick-walled polymer nanocapsules via the single-step assembly of macromolecules in solid core/mesoporous shell (SC/MS) silica particle templates, followed by cross-linking of the macromolecules and removal of the SC/MS templates. The general applicability of this approach is demonstrated by the preparation of nanocapsules using various polymers, including synthetic polyelectrolytes, polypeptides, and polypeptide-drug conjugates. The potential of doxorubicin (Dox)-loaded poly(L-glutamic acid) nanocapsules in tumor therapy applications is demonstrated via in vitro degradation experiments, which show a near-linear release of the Dox in the presence of a lysosomal hydrolase, nanocapsule uptake by human colorectal tumor cells, and delivery of the anticancer drug into the tumor cells, leading to tumor cell death.
Degradable, Surfactant-Free, Monodisperse Polymer-Encapsulated Emulsions as Anticancer Drug Carriers

Sivakumar, S ; Bansal, V ; Cortez, C ; Chong, S-F ; Zelikin, AN ; Caruso, F (WILEY-V C H VERLAG GMBH, 2009-05-11)