Otolaryngology - Theses

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The protective effects of systemic steroids on residual hearing post cochlear implantation

Ismail, Hudaifa ( 2012)

The aim of this study is to assess residual hearing after cochlear implantation with administration of systemic dexamethasone. In accordance with previous studies carried out by the hearing protection team at Royal Victorian Eye and Ear Hospital the purpose of this study is to observe the relationship between a single dose of intra-venous dexamethasone administration and residual hearing protection. This thesis will address whether hearing protection is sustained by observing functional outcomes in guinea pigs for three months after single dose of intravenous dexamethasone administration. Seventeen normal hearing guinea pigs were randomly allocated to receive an intravenous injection of (2 mg/kg) dose of dexamethasone 60 min prior to cochlear implantation or topical (Round window) application of normal saline pad (control) 30 min prior to cochlear implantation. Auditory brainstem response (ABR) threshold shifts at 2, 8,16, 24 and 32 kHz were measured and a comparison between pre- and 12 weeks post-operative levels was carried out.