Optometry and Vision Sciences - Research Publications

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Focal Activation of Primary Visual Cortex Following Supra-choroidal Electrical Stimulation of the Retina: Intrinsic Signal Imaging and Linear Model Analysis

Cloherty, SL ; Hietanen, MA ; Suaning, GJ ; Ibbotson, MR (IEEE, 2010-01-01)

UNLABELLED: We performed optical intrinsic signal imaging of cat primary visual cortex (Area 17 and 18) while delivering bipolar electrical stimulation to the retina by way of a supra-choroidal electrode array. Using a general linear model (GLM) analysis we identified statistically significant (p < 0.01) activation in a localized region of cortex following supra-threshold electrical stimulation at a single retinal locus. OUR RESULTS: (1) demonstrate that intrinsic signal imaging combined with linear model analysis provides a powerful tool for assessing cortical responses to prosthetic stimulation, and (2) confirm that supra-choroidal electrical stimulation can achieve localized activation of the cortex consistent with focal activation of the retina.