Optometry and Vision Sciences - Research Publications

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Retinal ganglion cells electrophysiology: the effect of cell morphology on impulse waveform

Maturana, MI ; Wong, R ; Cloherty, SL ; Ibbotson, MR ; Hadjinicolaou, AE ; Grayden, DB ; Burkitt, AN ; Meffin, H ; O'Brien, BJ ; Kameneva, T (IEEE, 2013-01-01)

There are 16 morphologically defined classes of rats retinal ganglion cells (RGCs). Using computer simulation of a realistic anatomically correct A1 mouse RGC, we investigate the effect of the cell's morphology on its impulse waveform, using the first-, and second-order time derivatives as well as the phase plot features. Using whole cell patch clamp recordings, we recorded the impulse waveform for each of the rat RGCs types. While we found some clear differences in many features of the impulse waveforms for A2 and B2 cells compared to other cell classes, many cell types did not show clear differences.