Optometry and Vision Sciences - Research Publications

Permanent URI for this collection

http://hdl.handle.net/11343/312

Filters

2013 1
1
Reset filters

Settings
Statistics
Citations
Author: Vingrys, Algis × Author: Nguyen, Christine × Subject: Optometry and Ophthalmology not elsewhere classified; Hearing ×

Search Results

Now showing 1 - 1 of 1
  • Item
    Thumbnail Image
    Increased Susceptibility to Injury in Older Eyes
    Charng, J ; Nguyen, CTO ; Vingrys, AJ ; Jobling, AI ; Bui, BV (LIPPINCOTT WILLIAMS & WILKINS, 2013-03)
    PURPOSE: To determine whether there is an age-dependent susceptibility in retinal function in response to repeated anterior chamber cannulation with or without intraocular pressure (IOP) elevation. METHODS: Baseline electroretinograms were measured in 3- and 18-month-old Sprague-Dawley rats (n = 16 each group). Following baseline assessment, eyes were randomly assigned to undergo a 60-min anterior chamber cannulation with IOP either left at baseline (sham, 15 mm Hg) or elevated to 60 mm Hg. This was repeated three additional times, with each episode separated by 1 week. At weeks 1 to 3, dark-adapted retinal function was assessed immediately before cannulation, with final functional assessment at week 4. RESULTS: Both sham and IOP elevated eyes of older rats showed retinal dysfunction, which became more pronounced with the number of repeated insults. This effect was largest for responses arising from the inner retina. Repeated insult in younger eyes did not produce a change in amplitude but an increase in the sensitivity to light of photoreceptoral and bipolar cell components of the electroretinogram. CONCLUSIONS: Repeated trauma, not IOP, produces permanent retinal dysfunction in older eyes. Younger eyes appear to be able to withstand this type of injury by upregulating sensitivity of outer and middle retinal responses to maintain normal inner retinal function.