The principal focus of this dissertation is the pathology and pathogenesis of neurological disorders, both spontaneously-arising veterinary neurological diseases and animal models of human neurological disorders (comparative neuropathology). Ocular manifestations of some neurotoxicities were also studied.
A range of neurological disorders was studied and these diseases were better characterised using gross and histopathological examinations, abetted by ancillary diagnostic techniques, including ultrastructural pathology (transmission and scanning electron microscopy), immunohistochemistry, toxicology, tissue culture, and clinical pathology (clinical chemistry and haematology).
A major aim of these studies was to better characterise brain (and ocular) lesions that could be diagnostically useful.
These studies have been grouped into the following disease categories. Relevant publications are summarised and paper details cited after each disease entity.