Pharmacology and Therapeutics - Research Publications

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Type: Journal Article × Author: Burnstock, Geoffrey × Author: Beart, Philip × Author: Barnes, Nicholas ×

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    THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Overview.
    Alexander, SP ; Kelly, E ; Marrion, NV ; Peters, JA ; Faccenda, E ; Harding, SD ; Pawson, AJ ; Sharman, JL ; Southan, C ; Buneman, OP ; Cidlowski, JA ; Christopoulos, A ; Davenport, AP ; Fabbro, D ; Spedding, M ; Striessnig, J ; Davies, JA ; CGTP Collaborators, (Wiley, 2017-12)
    The Concise Guide to PHARMACOLOGY 2017/18 is the third in this series of biennial publications. This version provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide represents approximately 400 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point-in-time record that will survive database updates. The full contents of this section can be found at http://onlinelibrary.wiley.com/doi/10.1111/bph.13882/full. In addition to this overview, in which are identified 'Other protein targets' which fall outside of the subsequent categorisation, there are eight areas of focus: G protein-coupled receptors, ligand-gated ion channels, voltage-gated ion channels, other ion channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid-2017, and supersedes data presented in the 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature Committee of the Union of Basic and Clinical Pharmacology (NC-IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate.