- Microbiology & Immunology - Research Publications
Microbiology & Immunology - Research Publications
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ItemEnergy Efficient Time Synchronization in WSN for Critical Infrastructure MonitoringRao, AS ; Gubbi, J ; Tuan, N ; Nguyen, J ; Palaniswami, M ; Wyld, DC ; Wozniak, M ; Chaki, N ; Meghanathan, N ; Nagamalai, D (SPRINGER-VERLAG BERLIN, 2011-01-01)Wireless Sensor Networks (WSN) based Structural Health Monitoring (SHM) is becoming popular in analyzing the life of critical infrastructure such as bridges on a continuous basis. For most of the applications, data aggregation requires high sampling rate. A need for accurate time synchronization in the order of 0.6 − 9 μs every few minutes is necessary for data collection and analysis. Two-stage energy-efficient time synchronization is proposed in this paper. Firstly, the network is divided into clusters and a head node is elected using Low-Energy Adaptive Clustering Hierarchy based algorithm. Later, multiple packets of different lengths are used to estimate the delay between the elected head and the entire network hierarchically at different levels. Algorithmic scheme limits error to 3-hop worst case synchronization error. Unlike earlier energy-efficient time synchronization schemes, the achieved results increase the lifetime of the network.
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ItemThe T3SS Effector EspT Defines a New Category of Invasive Enteropathogenic E. coli (EPEC) Which Form Intracellular Actin PedestalsBulgin, R ; Arbeloa, A ; Goulding, D ; Dougan, G ; Crepin, VF ; Raymond, B ; Frankel, G ; Van Nhieu, GT (PUBLIC LIBRARY SCIENCE, 2009-12)Enteropathogenic Escherichia coli (EPEC) strains are defined as extracellular pathogens which nucleate actin rich pedestal-like membrane extensions on intestinal enterocytes to which they intimately adhere. EPEC infection is mediated by type III secretion system effectors, which modulate host cell signaling. Recently we have shown that the WxxxE effector EspT activates Rac1 and Cdc42 leading to formation of membrane ruffles and lamellipodia. Here we report that EspT-induced membrane ruffles facilitate EPEC invasion into non-phagocytic cells in a process involving Rac1 and Wave2. Internalized EPEC resides within a vacuole and Tir is localized to the vacuolar membrane, resulting in actin polymerization and formation of intracellular pedestals. To the best of our knowledge this is the first time a pathogen has been shown to induce formation of actin comets across a vacuole membrane. Moreover, our data breaks the dogma of EPEC as an extracellular pathogen and defines a new category of invasive EPEC.
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ItemPrecision Medicine: Dawn of Supercomputing in ‘omics ResearchReumann, M ; Holt, KE ; Inouye, M ; Stinear, T ; Goudey, B ; Abraham, G ; WANG, Q ; Shi, F ; Kowalczyk, A ; Pearce, A ; Isaac, A ; Pope, BJ ; Butzkueven, H ; Wagner, J ; Moore, S ; Downton, M ; Church, PC ; Turner, SJ ; Field, J ; Southey, M ; Bowtell, D ; Schmidt, D ; Makalic, E ; Zobel, J ; Hopper, J ; Petrovski, S ; O'Brien, T (eResearch Australasia, 2011)