Obstetrics and Gynaecology - Research Publications

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Author: Donoghue, Jacqueline × Author: Girling, Jane × Author: Rogers, Peter × Start date: 2020 × Type: Journal Article ×

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    A molecular staging model for accurately dating the endometrial biopsy
    Teh, WT ; Chung, J ; Holdsworth-Carson, SJ ; Donoghue, JF ; Healey, M ; Rees, HC ; Bittinger, S ; Obers, V ; Sloggett, C ; Kendarsari, R ; Fung, JN ; Mortlock, S ; Montgomery, GW ; Girling, JE ; Rogers, PAW (NATURE PORTFOLIO, 2023-10-06)
    Natural variability in menstrual cycle length, coupled with rapid changes in endometrial gene expression, makes it difficult to accurately define and compare different stages of the endometrial cycle. Here we develop and validate a method for precisely determining endometrial cycle stage based on global gene expression. Our 'molecular staging model' reveals significant and remarkably synchronised daily changes in expression for over 3400 endometrial genes throughout the cycle, with the most dramatic changes occurring during the secretory phase. Our study significantly extends existing data on the endometrial transcriptome, and for the first time enables identification of differentially expressed endometrial genes with increasing age and different ethnicities. It also allows reinterpretation of all endometrial RNA-seq and array data that has been published to date. Our molecular staging model will significantly advance understanding of endometrial-related disorders that affect nearly all women at some stage of their lives, such as heavy menstrual bleeding, endometriosis, adenomyosis, and recurrent implantation failure.
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    The genetic basis of endometriosis and comorbidity with other pain and inflammatory conditions
    Rahmioglu, N ; Mortlock, S ; Ghiasi, M ; Moller, PL ; Stefansdottir, L ; Galarneau, G ; Turman, C ; Danning, R ; Law, MH ; Sapkota, Y ; Christofidou, P ; Skarp, S ; Giri, A ; Banasik, K ; Krassowski, M ; Lepamets, M ; Marciniak, B ; Noukas, M ; Perro, D ; Sliz, E ; Sobalska-Kwapis, M ; Thorleifsson, G ; Topbas-Selcuki, NF ; Vitonis, A ; Westergaard, D ; Arnadottir, R ; Burgdorf, KS ; Campbell, A ; Cheuk, CSK ; Clementi, C ; Cook, J ; De Vivo, I ; DiVasta, A ; Dorien, O ; Donoghue, JF ; Edwards, T ; Fontanillas, P ; Fung, JN ; Geirsson, RT ; Girling, JE ; Harkki, P ; Harris, HR ; Healey, M ; Heikinheimo, O ; Holdsworth-Carson, S ; Hostettler, IC ; Houlden, H ; Houshdaran, S ; Irwin, JC ; Jarvelin, M-R ; Kamatani, Y ; Kennedy, SH ; Kepka, E ; Kettunen, J ; Kubo, M ; Kulig, B ; Kurra, V ; Laivuori, H ; Laufer, MR ; Lindgren, CM ; MacGregor, S ; Mangino, M ; Martin, NG ; Matalliotaki, C ; Matalliotakis, M ; Murray, AD ; Ndungu, A ; Nezhat, C ; Olsen, CM ; Opoku-Anane, J ; Padmanabhan, S ; Paranjpe, M ; Peters, M ; Polak, G ; Porteous, DJ ; Rabban, J ; Rexrode, KM ; Romanowicz, H ; Saare, M ; Saavalainen, L ; Schork, AJ ; Sen, S ; Shafrir, AL ; Siewierska-Gorska, A ; Slomka, M ; Smith, BH ; Smolarz, B ; Szaflik, T ; Szyllo, K ; Takahashi, A ; Terry, KL ; Tomassetti, C ; Treloar, SA ; Vanhie, A ; Vincent, K ; Vo, KC ; Werring, DJ ; Zeggini, E ; Zervou, M ; Stefansson, K ; Nyegaard, M ; Uimari, O ; Yurttas-Beim, P ; Tung, JY ; Adachi, S ; Buring, JE ; Ridker, PM ; D'Hooghe, T ; Goulielmos, GN ; Hapangama, DK ; Hayward, C ; Horne, AW ; Low, S-K ; Martikainen, H ; Chasman, D ; Rogers, PAW ; Saunders, PT ; Sirota, M ; Spector, T ; Strapagiel, D ; Whiteman, DC ; Giudice, LC ; Velez-Edwards, DR ; Kraft, P ; Salumets, A ; Nyholt, DR ; Magi, R ; Becker, CM ; Steinthorsdottir, V ; Missmer, SA ; Montgomery, GW ; Morris, AP ; Zondervan, KT (NATURE PORTFOLIO, 2023-03)
    Endometriosis is a common condition associated with debilitating pelvic pain and infertility. A genome-wide association study meta-analysis, including 60,674 cases and 701,926 controls of European and East Asian descent, identified 42 genome-wide significant loci comprising 49 distinct association signals. Effect sizes were largest for stage 3/4 disease, driven by ovarian endometriosis. Identified signals explained up to 5.01% of disease variance and regulated expression or methylation of genes in endometrium and blood, many of which were associated with pain perception/maintenance (SRP14/BMF, GDAP1, MLLT10, BSN and NGF). We observed significant genetic correlations between endometriosis and 11 pain conditions, including migraine, back and multisite chronic pain (MCP), as well as inflammatory conditions, including asthma and osteoarthritis. Multitrait genetic analyses identified substantial sharing of variants associated with endometriosis and MCP/migraine. Targeted investigations of genetically regulated mechanisms shared between endometriosis and other pain conditions are needed to aid the development of new treatments and facilitate early symptomatic intervention.
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    Dilated Thin-Walled Blood and Lymphatic Vessels in Human Endometrium: A Potential Role for VEGF-D in Progestin-Induced Break-Through Bleeding (vol 7, e30916, 2012)
    Donoghue, JF ; McGavigan, CJ ; Lederman, FL ; Cann, LM ; Fu, L ; Dimitriadis, E ; Girling, JE ; Rogers, PAW (PUBLIC LIBRARY SCIENCE, 2021-10-26)
    [This corrects the article DOI: 10.1371/journal.pone.0030916.].