Obstetrics and Gynaecology - Research Publications

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Author: Donoghue, Jacqueline × Author: Healey, Martin × Author: Rogers, Peter × End date: 2023 × Start date: 2021 × Type: Journal Article ×

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    A molecular staging model for accurately dating the endometrial biopsy
    Teh, WT ; Chung, J ; Holdsworth-Carson, SJ ; Donoghue, JF ; Healey, M ; Rees, HC ; Bittinger, S ; Obers, V ; Sloggett, C ; Kendarsari, R ; Fung, JN ; Mortlock, S ; Montgomery, GW ; Girling, JE ; Rogers, PAW (NATURE PORTFOLIO, 2023-10-06)
    Natural variability in menstrual cycle length, coupled with rapid changes in endometrial gene expression, makes it difficult to accurately define and compare different stages of the endometrial cycle. Here we develop and validate a method for precisely determining endometrial cycle stage based on global gene expression. Our 'molecular staging model' reveals significant and remarkably synchronised daily changes in expression for over 3400 endometrial genes throughout the cycle, with the most dramatic changes occurring during the secretory phase. Our study significantly extends existing data on the endometrial transcriptome, and for the first time enables identification of differentially expressed endometrial genes with increasing age and different ethnicities. It also allows reinterpretation of all endometrial RNA-seq and array data that has been published to date. Our molecular staging model will significantly advance understanding of endometrial-related disorders that affect nearly all women at some stage of their lives, such as heavy menstrual bleeding, endometriosis, adenomyosis, and recurrent implantation failure.
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    Peripheral, Central, and Cross Sensitization in Endometriosis-Associated Pain and Comorbid Pain Syndromes.
    McNamara, HC ; Frawley, HC ; Donoghue, JF ; Readman, E ; Healey, M ; Ellett, L ; Reddington, C ; Hicks, LJ ; Harlow, K ; Rogers, PAW ; Cheng, C (Frontiers Media S.A., 2021)
    Endometriosis-associated pain and the mechanisms responsible for its initiation and persistence are complex and difficult to treat. Endometriosis-associated pain is experienced as dysmenorrhea, cyclical pain related to organ function including dysuria, dyschezia and dyspareunia, and persistent pelvic pain. Pain symptomatology correlates poorly with the extent of macroscopic disease. In addition to the local effects of disease, endometriosis-associated pain develops as a product of peripheral sensitization, central sensitization and cross sensitization. Endometriosis-associated pain is further contributed to by comorbid pain conditions, such as bladder pain syndrome, irritable bowel syndrome, abdomino-pelvic myalgia and vulvodynia. This article will review endometriosis-associated pain, its mechanisms, and its comorbid pain syndromes with a view to aiding the clinician in navigating the literature and terminology of pain and pain syndromes. Limitations of our current understanding of endometriosis-associated pain will be acknowledged. Where possible, commonalities in pain mechanisms between endometriosis-associated pain and comorbid pain syndromes will be highlighted.