Obstetrics and Gynaecology - Research Publications

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Author: Hickey, Martha × Author: Dang, Tri Christa × Type: Journal Article × Start date: 2010 × End date: 2019 ×

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    Unhealthy habits persist: The ongoing presence of modifiable risk factors for disease in women
    Szoeke, C ; Dang, C ; Lehert, P ; Hickey, M ; Morris, ME ; Dennerstein, L ; Campbell, S ; Vassalle, C (PUBLIC LIBRARY SCIENCE, 2017-04-12)
    OBJECTIVES: Vascular disease remains a leading cause of death. There are several vascular risk factors identified that can mitigate development of disease in ageing. We examine reported rates of modifiable risk factors in women responding to an online health questionnaire advertised by popular media. METHODS: A sample of 26 620 women aged over 18 was examined in 2015 with a cross-sectional health questionnaire. The questionnaire included self-reported health, mood, lifestyle and vascular risk factors. RESULTS: There remains high rates of modifiable risk factors present in women. The vast majority of women (80%) reported not eating enough fruit and vegetables. Compared to the guidelines for health, the majority did not perform enough weekly physical activity (70%) and more than half the participants were overweight (54%). Sufficient fruit, vegetables, fish, legumes and physical activity were reported in less than 30% of women! CONCLUSIONS: Women continue to report low rates of physical activity, fruit and vegetable intake and higher BMI than recommended for good health, despite worldwide health promotion activities aimed at changing these lifestyle factors. Programs to support healthy living need to be reviewed and revised to reduce the burden of vascular disease and dementia in women. Previous guidelines are not having the important impact they should, particularly in women.
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    Unhealthy habits persist: The ongoing presence of modifiable risk factors for disease in women (vol 12, e0173603, 2017)
    Szoeke, C ; Dang, C ; Lehert, P ; Hickey, M ; Morris, ME ; Dennerstein, L ; Campbell, S (PUBLIC LIBRARY SCIENCE, 2017-07-07)
    [This corrects the article DOI: 10.1371/journal.pone.0173603.].
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    Rates of age- and amyloid β-associated cortical atrophy in older adults with superior memory performance
    Dang, C ; Yassi, N ; Harrington, KD ; Xia, Y ; Lim, YY ; Ames, D ; Laws, SM ; Hickey, M ; Rainey-Smith, S ; Sohrabi, HR ; Doecke, JD ; Fripp, J ; Salvado, O ; Snyder, PJ ; Weinborn, M ; Villemagne, VL ; Rowe, CC ; Masters, CL ; Maruff, P (WILEY, 2019-12)
    INTRODUCTION: Superior cognitive performance in older adults may reflect underlying resistance to age-associated neurodegeneration. While elevated amyloid β (Aβ) deposition (Aβ+) has been associated with increased cortical atrophy, it remains unknown whether "SuperAgers" may be protected from Aβ-associated neurodegeneration. METHODS: Neuropsychologically defined SuperAgers (n = 172) and cognitively normal for age (n = 172) older adults from the Australian Imaging, Biomarkers and Lifestyle study were case matched. Rates of cortical atrophy over 8 years were examined by SuperAger classification and Aβ status. RESULTS: Of the case-matched SuperAgers and cognitively normal for age older adults, 40.7% and 40.1%, respectively, were Aβ+. Rates of age- and Aβ-associated atrophy did not differ between the groups on any measure. Aβ- individuals displayed the slowest rates of atrophy. DISCUSSION: Maintenance of superior memory in late life does not reflect resistance to age- or Aβ-associated atrophy. However, those individuals who reached old age without cognitive impairment nor elevated Aβ deposition (i.e. Aβ-) displayed reduced rates of cortical atrophy.