Obstetrics and Gynaecology - Research Publications

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    Combination methotrexate and gefitinib: A potential medical treatment for inoperable nontubal ectopic pregnancy
    Italiano, S ; Tong, S ; Readman, E ; Tassone, M ; Hastie, R ; Pritchard, N (WILEY, 2019-12-09)
    Nontubal ectopic pregnancies present as a therapeutic challenge. A 35-year-old primigravida at 7 weeks gestation had a live interstitial ectopic pregnancy and contraindications to surgery. The patient was treated with a multidose methotrexate regimen combined with oral gefitinib (250 mg daily for 7 days). The peak human chorionic gonadotropin (hCG) of the patient was recorded at 19 510 IU/L and began declining from day 4 of combination therapy (day 6 of initial treatment). Successful resolution of the ectopic was demonstrated by cessation of the fetal heart by day 15 and hCG falling to 23 IU/L by day 42. A 10-year review of all nontubal ectopic pregnancies treated with methotrexate identified 46 cases, which had a comparable time to resolution to combination therapy. However, for cases where cardiac activity was present, the median time to resolution following methotrexate treatment was 64 days (47-87 days), 22 days longer than combination therapy. Combination therapy may provide a safe medical treatment for inoperable nontubal ectopic pregnancy.
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    Sex variation in perinatal outcomes by infertility treatment modality in a population cohort
    Davies, M ; Rumbold, A ; Marino, J ; Willson, K ; Moore, V ; Giles, L (OXFORD UNIV PRESS, 2013-06-01)