Veterinary and Agricultural Sciences Collected Works - Research Publications

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    PATHOGENESIS OF VIRUS-INDUCED DEMYELINATION
    FAZAKERLEY, JK ; BUCHMEIER, MJ ; Maramorosch, K ; Murphy, FA ; Shatkin, AJ (ELSEVIER ACADEMIC PRESS INC, 1993-01-01)
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    THE V5A13.1 ENVELOPE GLYCOPROTEIN DELETION MUTANT OF MOUSE HEPATITIS-VIRUS TYPE-4 IS NEUROATTENUATED BY ITS REDUCED RATE OF SPREAD IN THE CENTRAL-NERVOUS-SYSTEM
    FAZAKERLEY, JK ; PARKER, SE ; BLOOM, F ; BUCHMEIER, MJ (ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS, 1992-03-01)
    Following intracerebral inoculation of adult Balb/c Byj mice, the MHV-4 strain of mouse hepatitis virus (MHV) had an LD50 of less than 0.1 PFU, whereas its monoclonal antibody resistant variant V5A13.1 had an LD50 of 10(4.2) PFU. To determine the basis for this difference in neurovirulence we have studied the acute central nervous system (CNS) infection of these two viruses by in situ hybridization. Both viruses infected the same, specific neuroanatomical areas, predominantly neurons, and spread via the cerebrospinal fluid, along neuronal pathways and between adjacent cells. The neuronal nuclei infected and the spread of virus within the brain are described. The main difference between the parental and variant viruses was the rate at which the infection spread. MHV-4 spread rapidly, destroying large numbers of neurons and the animals died within 4 days of infection. The variant virus spread to the same areas of the brain but at a slower rate. This difference in the rate of virus spread was also apparent from the brain virus titers. The slower rate of spread of the variant virus appears to allow intervention by the immune response. Consistent with this, the variant virus spread slowly in athymic nu/nu mice, but in the absence of an intact immune response, infection and destruction of neurons eventually reached the same extent as that of the parental virus and the mice died within 6 days of infection. We conclude that the V5A13.1 variant of MHV-4 is neuroattenuated by its slower rate of spread in the CNS.
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    THE EMERGING ROLE FOR AGRICULTURAL EDUCATION IN PRODUCING FUTURE RESEARCHERS
    Falvey, L ; Maguire, C (Journal of International Agricultural and Extension Education, 1997-01-01)
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    INSTITUTIONAL ARRANGEMENTS IN AGRICULTURAL EDUCATION, EXTENSION, AND RESEARCH: LESSONS FOR INTERNATIONAL DEVELOPMENT
    Falvey, L ; Forno, D (Journal of International Agricultural and Extension Education, 1997-01-01)
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    Formal Agricultural Education: Origins of Agricultural Knowledge Systems
    Falvey, J (Asian Agri-History Foundation, 1997)
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    Attracting the Shining Stars to Agriculture.
    Falvey, J (Australian Institute of Agricultural Science and Technology, 1997)
    While one will expect partnerships of convenience from time to time. the long-term prospect for agricultural education is based on the recognition of its role as an applied area of social and natural sciences supporting agriculture. Industry and research funders. among others. are also sending this message (Falvey and Ma!!hews. 1997). As an applied field, it behoves us to link strongly with all stakeholders in policy formulation. planning. implementation and funding.
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    Food and Environmental Science
    Falvey, J (Australian Science Teachers Association, 1997)
    The negative impact of food production on the environment is of increasing public concern and more sensitive production systems such as organic farming are often proposed. Such views miss the point that this global issue must be considered in terms of essential tradeoffs which require more and better science in the fields of food and environment, such as in agricultural science courses. Global population will continue to grow and demographic shifts and poverty will require massive increases in food production which can only be provided from intensive agriculture. Declining food prices and extreme poverty in some countries will continue to orient food producers to short term gains. All of these factors suggest that intensive agriculture restricted to suitable lands will be required for the foreseeable future. Balancing environmental care with food production is a challenge which continues to demand the best minds for research and education. We cannot isolate ourselves from the world in which we live.
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    Food Production and Natural Resource Management
    Falvey, L (Informa UK Limited, 1998-01)
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    The Future Shape of Agricultural Research
    Falvey, J (Australian Institute of Agricultural Science and Technology, 1998)
    Agricultural research has changed in orientation since its inception; we must continue to expect change. Publicly funded, institutionalised research has been a significant development to, and through, this era and is evolving to a more mature system.
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    STAKEHOLDER VIEWS ON AGRICULTURAL EDUCATION IN AUSTRALIA
    Falvey, L ; Matthews, B (Journal of International Agricultural and Extension Education, 1999-01-01)