The subject of Religious Education (RE) is the one feature distinguishing Catholic Schools from Government Schools. It is a unique subject because its impact on students' lives is long-lasting and important. The factors influencing students' attitudes and perceptions of RE are examined in this study. Two of the main factors researched here include the content of Religious Education lessons and the methodology employed by teachers, as perceived by students. Marked differences in the gender responses of students were observed to be very significant and these are discussed and explored. Recommendations for possible ways of addressing these disparities are also included.