Infrastructure Engineering - Research Publications
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ItemDetecting structural damage to bridge girders using radar interferometry and computational modelling(JOHN WILEY & SONS LTD, 2017-10)The process for assessing the condition of a bridge involves continuously monitoring changes to the material properties, support conditions, and system connectivity throughout its life cycle. It is known that the structural integrity of bridges can be monitored by measuring their vibration responses. However, the relationship between frequency changes and structural damage is still not fully understood. This study presents a bridge condition assessment framework which integrates computational modelling and noncontact radar sensor techniques (i.e., IBIS-S) to predict changes in the natural frequencies of a bridge girder as a result of a range of parameters that govern its structural performance (e.g., elastomeric bearing stiffness, concrete compressive stiffness, and crack propagation). Using a prestressed concrete bridge in Australia as a case study, the research outcomes suggest that vibration monitoring using IBIS-S is an efficient way for detecting the degradation of elastomeric bearing stiffness and shear crack propagation in the support areas that can significantly affect the overall structural integrity of a bridge structure. However, frequency measurements have limited capability for detecting the decrease in the material properties of a bridge girder.
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ItemBone fracture healing under Ilizarov fixator: Influence of fixator configuration, fracture geometry, and loading(WILEY, 2019-06-01)This study aims to enhance the understanding of the relationship between Ilizarov fixator configuration and its effects on bone fracture healing. Using Taylor spatial frame (TSF) as an example, the roles of critical parameters (ie, TSF ring diameter, wire pre‐tension, fracture gap size, and axial load) that govern fracture healing during the early stages were investigated by using computational modelling in conjunction with mechanical testing involving an advanced 3D optical measurement system. The computational model was first validated using the mechanical test results and then used to simulate mesenchymal stem cell (MSC) differentiations within different regions of the fracture site under various combinations of TSF ring diameter, wire pre‐tension, fracture gap size, and axial load values. Predicted spatially dependent MSC differentiation patterns and the influence of each parameter on differentiations were compared with in vivo results, and good agreement was seen between the two. Gap size was identified as the most influential parameter in MSC differentiation, and the influence of axial loading and TSF configuration (ie, ring diameter and wire pre‐tension) on cell differentiation was seen to be gap size dependent. Most changes in cell differentiation were predicted in the external callus (periosteal), which is the crucial region of the callus in the early stages. However, for small gap sizes (eg, 1 mm), significant changes were predicted in the endosteal callus as well. The study exhibits the potential of computational models in assessing the performance of Ilizarov fixators as well as assisting surgeons in patient‐specific clinical treatment planning.
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ItemRole of Dynamic Loading on Early Stage of Bone Fracture Healing(SPRINGER, 2018-11)After fracture, mesenchymal stem cells (MSCs) and growth factors migrate into the fracture callus to exert their biological actions. Previous studies have indicated that dynamic loading induced tissue deformation and interstitial fluid flow could produce a biomechanical environment which significantly affects the healing outcomes. However, the fundamental relationship between the various loading regimes and different healing outcomes has not still been fully understood. In this study, we present an integrated computational model to investigate the effect of dynamic loading on early stage of bone fracture healing. The model takes into account cell and growth factor transport under dynamic loading, and mechanical stimuli mediated MSC differentiation and tissue production. The developed model was firstly validated by the available experimental data, and then implemented to identify the loading regimes that produce the optimal healing outcomes. Our results demonstrated that dynamic loading enhances MSC and growth factor transport in a spatially dependent manner. For example, compared to free diffusion, dynamic loading could significantly increase MSCs concentration in endosteal zone; and chondrogenic growth factors in both cortical and periosteal zones in callus. Furthermore, there could be an optimal dynamic loading regime (e.g. 10% strain at 1 Hz) which could potentially significant enhance endochondral ossification.
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ItemThe investigation of fluid flow in cartilage contact gap(ELSEVIER SCIENCE BV, 2019-07)Synovial fluid flow in articular joint capsule plays an important role during mixed mode lubrication. However, the actual fluid flow behaviour during cartilage contact has not been fully understood so far. This is due to the difficulties in measuring the gap permeability using conventional experimental techniques. The problem becomes further complicated with consideration of the cartilage surface roughness. Here a validated numerical study was developed to quantify the gap permeability of lateral synovial fluid flow. Both macro- and micro-scale gap flow models were created based on Darcy's law at the macro-scale and the Navier-stokes equation at the micro-scale. To generate model inputs, the cartilage topography was numerically synthesised based on the experimental measurements of bovine medial tibia cartilage surface roughness using Dektak Stylus Profilers. The experimental results show that the average roughness height Ra is 1.97 μm and root-mean-square roughness height Rq is 2.44 μm, while the correlation lengths of the secondary and tertiary undulations are round 100 μm and 20 μm, respectively. The numerical results indicate that the contact gap height and fluid pressure gradient are two critical parameters which significantly affect the gap permeability. As the contact gap closes, there is a decrease in gap permeability, and most importantly, the gap permeability is also very sensitive to the fluid pressure gradient. Furthermore, with gap closure, the permeability of the contact gap gradually approaches that of the cartilage tissue, at which point the contact gap is functional closed. This occurs at a contact gap height around 1 μm and fluid pressure gradient below 5 × 105 Pa/m in this study.
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ItemRobot-assisted weight-bearing exercise for stroke patients with limited mobility(Sage Publications, 2019-06-01)Weight-bearing exercise is a well-accepted physiotherapy to prevent osteoporosis for stroke patients. But the immobility of stroke patients limits the types and intensity of conventional interventions. Recent advances in robot-assisted therapeutic device provide an innovative way which could potentially overcome the above-mentioned limitations. However, the effects of robot-assisted physiotherapy on osteoporosis prevention have not been fully understood. The purpose of the present study is to develop an innovative theoretical framework to investigate the effects of static robot-assisted walking exercise on bone health. Through conducting a series of studies using a robot, force insoles and CT-image-based computational modeling, our results show that robot-assisted walking can significantly reduce the osteoporosis risk for stroke patients. However, the vertical peak ground reaction forces generated from static robot walking is generally lower than that from treadmill walking due to the fact that there are no heel strike and push-off effects in static robotic walking.
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ItemThe role of impairment of mesenchymal stem cell function in osteoporotic bone fracture healing(SPRINGER, 2017-09)With demographic change and increasing life expectancy, osteoporotic fractures have become one of the most prevalent trauma conditions seen in daily clinical practice. A variety of factors are known to affect the rate of healing in osteoporotic conditions (e.g. both biochemical and biomechanical environment of callus cells). However, the influence of impairment of mesenchymal stem cell function in the osteoporotic condition on bone fracture healing has not been fully understood. In the present study, we develop a mathematical model that quantifies the change in biological processes within the fracture callus as a result of osteoporosis. The model includes special features of osteoporosis such as reduction in mesenchymal stem cell (MSC) number in osteoporotic bone, impaired response of osteoporotic MSCs to their biomechanical microenvironment and the effects of configuration of locking compression plate (LCP) system on healing in this context. The results presented here suggest that mechanically-mediated MSCs differentiation at early stages of healing are significantly affected under osteoporotic conditions, while it is predicted that the flexible fixation achieved by increasing bone-plate distance of LCP could alleviate the negative effects of osteoporosis on healing. The outcomes of this study could potentially lead to patient specific surgical solutions, and thus achieve optimal healing outcomes in osteoporotic conditions.
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ItemThe relationship between interfragmentary movement and cell differentiation in early fracture healing under locking plate fixation(Springer Netherlands, 2016)Interfragmentary movement (IFM) at the fracture site plays an important role in fracture healing, particularly during its early stage, via influencing the mechanical microenvironment of mesenchymal stem cells within the fracture callus. However, the effect of changes in IFM resulting from the changes in the configuration of locking plate fixation on cell differentiation has not yet been fully understood. In this study, mechanical experiments on surrogate tibia specimens, manufactured from specially formulated polyurethane, were conducted to investigate changes in IFM of fractures under various locking plate fixation configurations and loading magnitudes. The effect of the observed IFM on callus cell differentiation was then further studied using computational simulation. We found that during the early stage, cell differentiation in the fracture callus is highly influenced by fracture gap size and IFM, which in turn, is highly sensitive to locking plate fixation configuration. The computational model predicted that a small gap size (e.g. 1 mm) under a relatively flexible configuration of locking plate fixation (larger bone-plate distances and working lengths) could experience excessive strain and fluid flow within the fracture site, resulting in excessive fibrous tissue differentiation and delayed healing. By contrast, a relatively flexible configuration of locking plate fixation was predicted to improve cartilaginous callus formation and bone healing for a relatively larger gap size (e.g. 3 mm). If further confirmed by animal and human studies, the research outcome of this paper may have implications for orthopaedic surgeons in optimising the application of locking plate fixations for fractures in clinical practice.