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ItemThe carbon footprint of treating patients with septic shock in the intensive care unit(College of Intensive Care Medicine of Australia and New Zealand, 2018-12-01)OBJECTIVE: To use life cycle assessment to determine the environmental footprint of the care of patients with septic shock in the intensive care unit (ICU). DESIGN, SETTING AND PARTICIPANTS: Prospective, observational life cycle assessment examining the use of energy for heating, ventilation and air conditioning; lighting; machines; and all consumables and waste associated with treating ten patients with septic shock in the ICU at BarnesJewish Hospital, St. Louis, MO, United States (US-ICU) and ten patients at Footscray Hospital, Melbourne, Vic, Australia (Aus-ICU). MAIN OUTCOME MEASURES: Environmental footprint, particularly greenhouse gas emissions. RESULTS: Energy use per patient averaged 272 kWh/day for the US-ICU and 143 kWh/day for the Aus-ICU. The average daily amount of single-use materials per patient was 3.4 kg (range, 1.0-6.3 kg) for the US-ICU and 3.4 kg (range, 1.2-8.7 kg) for the Aus-ICU. The average daily particularly greenhouse gas emissions arising from treating patients in the US-ICU was 178 kg carbon dioxide equivalent (CO2-e) emissions (range, 165-228 kg CO2-e), while for the Aus-ICU the carbon footprint was 88 kg CO2-e (range, 77-107 kg CO2-e). Energy accounted for 155 kg CO2-e in the US-ICU (87%) and 67 kg CO2-e in the Aus-ICU (76%). The daily treatment of one patient with septic shock in the US-ICU was equivalent to the total daily carbon footprint of 3.5 Americans' CO2-e emissions, and for the Aus-ICU, it was equivalent to the emissions of 1.5 Australians. CONCLUSION: The carbon footprints of the ICUs were dominated by the energy use for heating, ventilation and air conditioning; consumables were relatively less important, with limited effect of intensity of patient care. There is large opportunity for reducing the ICUs' carbon footprint by improving the energy efficiency of buildings and increasing the use of renewable energy sources.
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ItemA Novel Approach for 3D Modeling and Geovisualization of Easement Rights in Apartments(CMV Verlag, 2018-12-01)
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ItemGrowth differentiation factor 15 is a myomitokine governing systemic energy homeostasis.(Rockefeller University Press, 2017-01-02)Reduced mitochondrial electron transport chain activity promotes longevity and improves energy homeostasis via cell-autonomous and -non-autonomous factors in multiple model systems. This mitohormetic effect is thought to involve the mitochondrial unfolded protein response (UPRmt), an adaptive stress-response pathway activated by mitochondrial proteotoxic stress. Using mice with skeletal muscle-specific deficiency of Crif1 (muscle-specific knockout [MKO]), an integral protein of the large mitoribosomal subunit (39S), we identified growth differentiation factor 15 (GDF15) as a UPRmt-associated cell-non-autonomous myomitokine that regulates systemic energy homeostasis. MKO mice were protected against obesity and sensitized to insulin, an effect associated with elevated GDF15 secretion after UPRmt activation. In ob/ob mice, administration of recombinant GDF15 decreased body weight and improved insulin sensitivity, which was attributed to elevated oxidative metabolism and lipid mobilization in the liver, muscle, and adipose tissue. Thus, GDF15 is a potent mitohormetic signal that safeguards against the onset of obesity and insulin resistance.
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ItemEliciting the mitochondrial unfolded protein response by nicotinamide adenine dinucleotide repletion reverses fatty liver disease in mice.(Ovid Technologies (Wolters Kluwer Health), 2016-04)UNLABELLED: With no approved pharmacological treatment, nonalcoholic fatty liver disease (NAFLD) is now the most common cause of chronic liver disease in Western countries and its worldwide prevalence continues to increase along with the growing obesity epidemic. Here, we show that a high-fat high-sucrose (HFHS) diet, eliciting chronic hepatosteatosis resembling human fatty liver, lowers hepatic nicotinamide adenine dinucleotide (NAD(+) ) levels driving reductions in hepatic mitochondrial content, function, and adenosine triphosphate (ATP) levels, in conjunction with robust increases in hepatic weight, lipid content, and peroxidation in C57BL/6J mice. To assess the effect of NAD(+) repletion on the development of steatosis in mice, nicotinamide riboside, a precursor of NAD(+) biosynthesis, was added to the HFHS diet, either as a preventive strategy or as a therapeutic intervention. We demonstrate that NR prevents and reverts NAFLD by inducing a sirtuin (SIRT)1- and SIRT3-dependent mitochondrial unfolded protein response, triggering an adaptive mitohormetic pathway to increase hepatic β-oxidation and mitochondrial complex content and activity. The cell-autonomous beneficial component of NR treatment was revealed in liver-specific Sirt1 knockout mice (Sirt1(hep-/-) ), whereas apolipoprotein E-deficient mice (Apoe(-/-) ) challenged with a high-fat high-cholesterol diet affirmed the use of NR in other independent models of NAFLD. CONCLUSION: Our data warrant the future evaluation of NAD(+) boosting strategies to manage the development or progression of NAFLD.
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ItemReduced oxidative capacity in macrophages results in systemic insulin resistance.(Springer Science and Business Media LLC, 2018-04-19)Oxidative functions of adipose tissue macrophages control the polarization of M1-like and M2-like phenotypes, but whether reduced macrophage oxidative function causes systemic insulin resistance in vivo is not clear. Here, we show that mice with reduced mitochondrial oxidative phosphorylation (OxPhos) due to myeloid-specific deletion of CR6-interacting factor 1 (Crif1), an essential mitoribosomal factor involved in biogenesis of OxPhos subunits, have M1-like polarization of macrophages and systemic insulin resistance with adipose inflammation. Macrophage GDF15 expression is reduced in mice with impaired oxidative function, but induced upon stimulation with rosiglitazone and IL-4. GDF15 upregulates the oxidative function of macrophages, leading to M2-like polarization, and reverses insulin resistance in ob/ob mice and HFD-fed mice with myeloid-specific deletion of Crif1. Thus, reduced macrophage oxidative function controls systemic insulin resistance and adipose inflammation, which can be reversed with GDF15 and leads to improved oxidative function of macrophages.
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ItemComparisons of cancer-associated fibroblasts in the intratumoral stroma and invasive front in colorectal cancer.(Ovid Technologies (Wolters Kluwer Health), 2019-05)The aim of this study was to evaluate the cytomorphologic maturity and molecular activation of cancer-associated fibroblasts (CAFs) in the intratumoral stroma and invasive front in colorectal cancer and understand how they affect cancer invasion and long-term oncological outcomes.The cytomorphologic maturity of and α-smooth muscle actin (α-SMA), fibroblast activation protein α (FAPα), and fibroblast-specific protein 1 (FSP-1) expression in CAFs in the intratumoral stroma (CAF) and the invasive front (CAF) of colorectal cancer tissues were compared (n = 147). The correlations between CAF maturation, molecular activity markers, and cancer invasion were evaluated by network analysis. Overall survival and systemic recurrence were analyzed to assess the oncological effects of CAF properties.The cytomorphologic maturation rate was comparable between CAF and CAF. The presence of mature CAFs was related to epidermal growth factor receptor overexpression in cancer cells. Expression rates of α-SMA (96.6%-98.0%) and FAPα (18.6%-22.9%) were similar between CAF and CAF. FSP-1 expression was more frequent in CAF than in CAF (66.4% vs 58.2%, P = .038). There was a significant decrease in FSP-1 expression in CAF and CAF in higher stages. The infiltrating growth pattern of the tumor was more frequent in the immature CAF. In colorectal cancer with perineural invasion and lymph node metastasis, FSP-1 expression in CAF was significantly lower. On multivariate analysis using the Cox proportional hazards model, immature CAF was found to be an independent prognostic factor of overall survival. In non-metastatic (stage I-III) colorectal cancer patients, CAF maturity was not a prognostic factor for systemic recurrence.Cytomorphologic maturity and molecular activation markers were similar between CAFs in the intratumoral stroma and invasive front of colorectal cancer.
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ItemCancer-Associated Fibroblasts and Desmoplastic Reactions Related to Cancer Invasiveness in Patients With Colorectal Cancer.(Korean Society of Coloproctology, 2019-02)PURPOSE: We evaluated the relationship of cancer-associated fibroblasts (CAFs) and desmoplastic reactions with cancer invasiveness and long-term outcomes in patients with colorectal cancer (CRC). METHODS: Histologic evaluation of mature CAFs and desmoplasia was performed by observing the collagen fiber structure and fibroblast cytomorphology in the intratumoral stroma and invasive front of CRC tissues. Cancer-cell invasiveness was evaluated using lymphatic invasion, vascular invasion, perineural invasion, tumor budding, and tumor growth patterns. Overall survival and systemic recurrence were analyzed. A network analysis was performed between CAF maturation, desmoplastic reaction, and cancer invasiveness. RESULTS: The proportions of mature CAFs in the intratumoral stroma and the invasive front were 57.6% and 60.3%, respectively. Epidermal growth factor receptor (EGFR) overexpression was significantly higher in the mature CAFs in the invasive front as compared to immature CAFs. Lymphatic invasion increased as the number of mature fibroblasts in the intratumoral stroma increased. Tumor budding was observed in almost half of both mature and immature stroma samples and occurred more frequently in infiltrating tumors. On network analysis, well-connected islands were identified that was associated with EGFR overexpression, CAF maturation, and infiltrating tumor growth patterns leading to tumor budding. CONCLUSION: The maturity of CAFs and desmoplastic reactions were associated with cancer invasion. However, the cytomorphologic characteristics of CAFs were insufficient as an independent prognostic factor for patients with CRC.
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ItemPlastic weed matting is better than jute or woodchips for controlling the invasive wetland grass Phalaris arundinacea, but not Phragmites australis.(Polymeria Publishing, 2016)Woven polypropylene (plastic) weed matting, jute and eucalypt woodchips were trialled for controlling reed canary grass (Phalaris arundinacea L.) and common reed (Phragmites australis (Cav.) Trin. ex Steud.). At two sites, one dominated by reed canary grass and the other by common reed, 50 m x 20 m was mowed and sprayed and ten (10 m x 10 m) plots established, eight of which were fenced. Plots were covered with either plastic weed matting, jute or eucalypt woodchips, or were controls. All plots were planted with native trees and shrubs and understorey plants. Plastic weed matting was the most effective at reducing regrowth of reed canary grass (<5% cover after one year) and promoting the growth of native plantings (>60% cover). Both plastic weed and jute matting were similarly effective at reducing its regrowth (to 10%), but both matting types were compromised by common reed regrowth. While trees and shrubs grew well across all fenced treatments ( 100% survival), understorey plants only established and grew where weed regrowth was controlled. Unfenced unguarded trees and shrubs were virtually eliminated by browsing. Plastic weed matting (combined with other control measures, and protection from browsers where necessary) may provide the best opportunity to control reed canary grass and facilitate wetland restoration.
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ItemBalancing Rural Household Livelihood and Regional Ecological Footprint in Water Source Areas of the South-to-North Water Diversion Project(MDPI AG, 2017-08)There is a knowledge gap and practical demand to understand the co-evolutionary relationship between rural household livelihood and regional ecological footprints for developing sustainable livelihoods in ecological conservation regions. This paper tracks the change trajectories of rural household livelihoods and regional ecological footprints in four water source areas of the South-to-North Water Diversion Project where various ecological and environmental protection projects and measures are being proposed to protect water quality. As a result, some concerns regarding rural livelihood have arisen. The sustainable livelihood approach developed by DFID (Department for International Development in UK) was used to measure the natural, physical, financial, human, and social capitals of rural livelihoods, while the ecological footprint accounting approach was used to calculate the amount of bio-productive spaces that produce the yearly resource flows for human consumption. The study period is 2000–2014 and data was obtained from the Statistical Yearbooks. The results show that the change trend of natural capitals of rural households, which have increased by 72.5% (SY), 98.8% (NY), 69.3% (TA), and 120.3% (JN) within 15 years, determine the overall change track of rural livelihoods and that rural household livelihood grows with the expansion of regional ecological footprints. Sensitivity of regional eco-footprints to rural livelihood varies from 5.8 to 0.5 in case areas. It is recommended that in the “post South-to-North Water Diversion era”, four policy instruments—population transfer and relocation, industrial restructuring and updating, rural infrastructure and community reconstruction, and cross-ecological compensation—should be adopted to improve sustainable livelihoods in these four water source areas.
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ItemKey factors influencing differences in stream water quality across space(WILEY, 2018-01-01)Globally, many rivers are experiencing declining water quality, for example, with altered levels of sediments, salts, and nutrients. Effective water quality management requires a sound understanding of how and why water quality differs across space, both within and between river catchments. Land cover, land use, land management, atmospheric deposition, geology and soil type, climate, topography, and catchment hydrology are the key features of a catchment that affect: (1) the amount of suspended sediment, nutrient, and salt concentrations in catchments (i.e., the source), (2) the mobilization ,and (3) the delivery of these constituents to receiving waters. There are, however, complexities in the relationship between landscape characteristics and stream water quality. The strength of this relationship can be influenced by the distance and spatial arrangement of constituent sources within the catchment, cross correlations between landscape characteristics, and seasonality. A knowledge gap that should be addressed in future studies is that of interactions and cross correlations between landscape characteristics. There is currently limited understanding of how the relationships between landscape characteristics and water quality responses can shift based on the other characteristics of the catchment. Understanding the many forces driving stream water quality and the complexities and interactions in these forces is necessary for the development of successful water quality management strategies. This knowledge could be used to develop predictive models, which would aid in forecasting of riverine water quality. WIREs Water 2018, 5:e1260. doi: 10.1002/wat2.1260 This article is categorized under: Science of Water > Hydrological Processes Science of Water > Water Quality