Infrastructure Engineering - Research Publications
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ItemA Novel Approach for 3D Modeling and Geovisualization of Easement Rights in Apartments(CMV Verlag, 2018-12-01)
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ItemNo Preview AvailableA predictive model for spatio-temporal variability in stream water quality( 2019-07-23)Abstract. Degraded water quality in rivers and streams can have large economic, societal and ecological impacts. Stream water quality can be highly variable both over space and time. To develop effective management strategies for riverine water quality, it is critical to be able to predict these spatio-temporal variabilities. However, our current capacity to model stream water quality is limited, particularly at large spatial scales across multiple catchments. This is due to a lack of understanding of the key controls that drive spatio-temporal variabilities of stream water quality. To address this, we developed a Bayesian hierarchical statistical model to analyse the spatio-temporal variability in stream water quality across the state of Victoria, Australia. The model was developed based on monthly water quality monitoring data collected at 102 sites over 21 years. The modelling focused on six key water quality constituents: total suspended solids (TSS), total phosphorus (TP), filterable reactive phosphorus (FRP), total Kjeldahl nitrogen (TKN), nitrate-nitrite (NOx), and electrical conductivity (EC). Among the six constituents, the models explained varying proportions of variation in water quality. EC was the most predictable constituent (88.6 % variability explained) and FRP had the lowest predictive performance (19.9 % variability explained). The models were validated for multiple sets of calibration/validation sites and showed robust performance. Temporal validation revealed a systematic change in the TSS model performance across most catchments since an extended drought period in the study region, highlighting potential shifts in TSS dynamics over the drought. Further improvements in model performance need to focus on: (1) alternative statistical model structures to improve fitting for the low concentration data, especially records below the detection limit; and (2) better representation of non-conservative constituents by accounting for important biogeochemical processes. We also recommend future improvements in water quality monitoring programs which can potentially enhance the model capacity, via: (1) improving the monitoring and assimilation of high-frequency water quality data; and (2) improving the availability of data to capture land use and management changes over time.
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ItemCancer-Associated Fibroblasts and Desmoplastic Reactions Related to Cancer Invasiveness in Patients With Colorectal Cancer.(Korean Society of Coloproctology, 2019-02)PURPOSE: We evaluated the relationship of cancer-associated fibroblasts (CAFs) and desmoplastic reactions with cancer invasiveness and long-term outcomes in patients with colorectal cancer (CRC). METHODS: Histologic evaluation of mature CAFs and desmoplasia was performed by observing the collagen fiber structure and fibroblast cytomorphology in the intratumoral stroma and invasive front of CRC tissues. Cancer-cell invasiveness was evaluated using lymphatic invasion, vascular invasion, perineural invasion, tumor budding, and tumor growth patterns. Overall survival and systemic recurrence were analyzed. A network analysis was performed between CAF maturation, desmoplastic reaction, and cancer invasiveness. RESULTS: The proportions of mature CAFs in the intratumoral stroma and the invasive front were 57.6% and 60.3%, respectively. Epidermal growth factor receptor (EGFR) overexpression was significantly higher in the mature CAFs in the invasive front as compared to immature CAFs. Lymphatic invasion increased as the number of mature fibroblasts in the intratumoral stroma increased. Tumor budding was observed in almost half of both mature and immature stroma samples and occurred more frequently in infiltrating tumors. On network analysis, well-connected islands were identified that was associated with EGFR overexpression, CAF maturation, and infiltrating tumor growth patterns leading to tumor budding. CONCLUSION: The maturity of CAFs and desmoplastic reactions were associated with cancer invasion. However, the cytomorphologic characteristics of CAFs were insufficient as an independent prognostic factor for patients with CRC.
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ItemReduced oxidative capacity in macrophages results in systemic insulin resistance.(Springer Science and Business Media LLC, 2018-04-19)Oxidative functions of adipose tissue macrophages control the polarization of M1-like and M2-like phenotypes, but whether reduced macrophage oxidative function causes systemic insulin resistance in vivo is not clear. Here, we show that mice with reduced mitochondrial oxidative phosphorylation (OxPhos) due to myeloid-specific deletion of CR6-interacting factor 1 (Crif1), an essential mitoribosomal factor involved in biogenesis of OxPhos subunits, have M1-like polarization of macrophages and systemic insulin resistance with adipose inflammation. Macrophage GDF15 expression is reduced in mice with impaired oxidative function, but induced upon stimulation with rosiglitazone and IL-4. GDF15 upregulates the oxidative function of macrophages, leading to M2-like polarization, and reverses insulin resistance in ob/ob mice and HFD-fed mice with myeloid-specific deletion of Crif1. Thus, reduced macrophage oxidative function controls systemic insulin resistance and adipose inflammation, which can be reversed with GDF15 and leads to improved oxidative function of macrophages.
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ItemComparisons of cancer-associated fibroblasts in the intratumoral stroma and invasive front in colorectal cancer.(Ovid Technologies (Wolters Kluwer Health), 2019-05)The aim of this study was to evaluate the cytomorphologic maturity and molecular activation of cancer-associated fibroblasts (CAFs) in the intratumoral stroma and invasive front in colorectal cancer and understand how they affect cancer invasion and long-term oncological outcomes.The cytomorphologic maturity of and α-smooth muscle actin (α-SMA), fibroblast activation protein α (FAPα), and fibroblast-specific protein 1 (FSP-1) expression in CAFs in the intratumoral stroma (CAF) and the invasive front (CAF) of colorectal cancer tissues were compared (n = 147). The correlations between CAF maturation, molecular activity markers, and cancer invasion were evaluated by network analysis. Overall survival and systemic recurrence were analyzed to assess the oncological effects of CAF properties.The cytomorphologic maturation rate was comparable between CAF and CAF. The presence of mature CAFs was related to epidermal growth factor receptor overexpression in cancer cells. Expression rates of α-SMA (96.6%-98.0%) and FAPα (18.6%-22.9%) were similar between CAF and CAF. FSP-1 expression was more frequent in CAF than in CAF (66.4% vs 58.2%, P = .038). There was a significant decrease in FSP-1 expression in CAF and CAF in higher stages. The infiltrating growth pattern of the tumor was more frequent in the immature CAF. In colorectal cancer with perineural invasion and lymph node metastasis, FSP-1 expression in CAF was significantly lower. On multivariate analysis using the Cox proportional hazards model, immature CAF was found to be an independent prognostic factor of overall survival. In non-metastatic (stage I-III) colorectal cancer patients, CAF maturity was not a prognostic factor for systemic recurrence.Cytomorphologic maturity and molecular activation markers were similar between CAFs in the intratumoral stroma and invasive front of colorectal cancer.
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ItemKey factors influencing differences in stream water quality across space(WILEY, 2018-01-01)
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ItemThe value of water in storage: Implications for operational policies(Curran Associate Inc., 2018-01-01)With desalination plants becoming an increasingly common feature of water supply systems for major cities, the options for managing water security are now markedly different to past times when the short-term response to low water availability essentially revolved around reducing usage. The operation of desalination plants and other components of diversified water supply systems now enable operators to increase availability, essentially by producing water. The operation of such systems clearly impacts operational costs but, more subtly, also impacts future augmentation decisions. This can have major cost implications as there is a trade-off between the costs of operating a water supply system and the probability and timing of future augmentations that leads to important differences in the economics of reliably supplying water. This paper first summarises an economic analysis framework in which to explore the interaction of short (operational) and long (capital investment) term decisions towards maintaining water security. It then explores the implications of different operation approaches in Melbourne’s water supply system, assuming a planned augmentation pathway under conditions of low water availability. We assume augmentation decisions are prompted by critically low water availability events, rather than long-term reliability analysis. We show that the majority of the variation in cost of maintaining a reliable water supply is associated with impacts of operational rules on likely capital investment and that this results in a strong interaction between short and long-term decision making. The outcome of this work has implications for both operational decision making and augmentation planning for urban water supply systems. These implications are relevant to any water supply system where a climate independent water supply source, such as desalination, can be accessed.
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ItemAn evaluation of a methodology for seasonal soil water forecasting for Australian dry land cropping systems(ELSEVIER SCIENCE BV, 2018-05-01)Soil water is a critical resource in many rain-fed agricultural systems. Climate variability represents a significant risk in these systems, which has been addressed in the past through seasonal weather outlooks. This study undertakes a pilot assessment of the potential to extend seasonal weather outlooks to plant available soil water (PASW). We analyse 20 sites in the southeast Australian wheat belt using seasonal weather outlooks from the Predictive Ocean-Atmosphere Model for Australia (POAMA; (the operational seasonal model of the Australian Bureau of Meteorology), which were downscaled and used in conjunction with the Agricultural Production Simulator (APSIM). Hindcast rainfall, potential evapotranspiration (PET) and PASW outlooks were produced on a monthly basis for 33 years at a point scale. The outlooks were assessed using a range of ensemble verification tools. The results showed hit rates that outperformed climatology for rainfall and PET in the short-term (0–2 months), and for PASW with longer lead times (2–5 months). Continuous rank probability skill scores (CRPSS) were generally statistically worse than climatology for rainfall and PET and statistically better than climatology for PASW over 1–3 months. The influence of initial soil water is seasonally dependent, with longer dependence in low evapotranspiration periods. Improved weather model downscaling approaches would transition to climatology and could improve both weather and PASW outlooks. PASW outlooks were strongly reliant on initial conditions, indicating the importance of understanding current soil water status, which needs to be interpreted in a seasonal context as its influence varies over the year. Expanded operational soil water monitoring would be important if PASW outlooks are to become routine.
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ItemPredicting groundwater recharge for varying land cover and climate conditions - a global meta-study(COPERNICUS GESELLSCHAFT MBH, 2018-05-07)Abstract. Groundwater recharge is one of the important factors determining the groundwater development potential of an area. Even though recharge plays a key role in controlling groundwater system dynamics, much uncertainty remains regarding the relationships between groundwater recharge and its governing factors at a large scale. Therefore, this study aims to identify the most influential factors of groundwater recharge, and to develop an empirical model to estimate diffuse rainfall recharge at a global scale. Recharge estimates reported in the literature from various parts of the world (715 sites) were compiled and used in model building and testing exercises. Unlike conventional recharge estimates from water balance, this study used a multimodel inference approach and information theory to explain the relationship between groundwater recharge and influential factors, and to predict groundwater recharge at 0.5∘ resolution. The results show that meteorological factors (precipitation and potential evapotranspiration) and vegetation factors (land use and land cover) had the most predictive power for recharge. According to the model, long-term global average annual recharge (1981–2014) was 134 mm yr−1 with a prediction error ranging from −8 to 10 mm yr−1 for 97.2 % of cases. The recharge estimates presented in this study are unique and more reliable than the existing global groundwater recharge estimates because of the extensive validation carried out using both independent local estimates collated from the literature and national statistics from the Food and Agriculture Organization (FAO). In a water-scarce future driven by increased anthropogenic development, the results from this study will aid in making informed decisions about groundwater potential at a large scale.
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ItemJustin Costelloe: a champion of arid-zone water research(Springer Verlag, 2019-11-06)Justin Francis Costelloe (Fig. 1) was born in 1965. He grew up in the mining city of Bendigo (Victoria, Australia) before studying Earth Sciences at the University of Melbourne. He went on to work as an exploration geologist in the mining industry in the dryland regions of Australia and Chile. He developed a love of Australia’s desert landscapes and returned to undertake Masters and PhD studies on arid zone hydrology at the University of Melbourne, before continuing as a research fellow and senior research fellow leading arid zone research projects. Justin was a leader in research aimed at understanding surface water and groundwater in Australia’s arid zone and also made important interdisciplinary contributions linking the hydrology and ecology of the arid zone, with a focus on Australia’s iconic Channel Country and the Great Artesian Basin (GAB).