Infrastructure Engineering - Research Publications
Permanent URI for this collection
Search Results
1 - 10 of 249
-
ItemThe carbon footprint of treating patients with septic shock in the intensive care unit(College of Intensive Care Medicine of Australia and New Zealand, 2018-12-01)OBJECTIVE: To use life cycle assessment to determine the environmental footprint of the care of patients with septic shock in the intensive care unit (ICU). DESIGN, SETTING AND PARTICIPANTS: Prospective, observational life cycle assessment examining the use of energy for heating, ventilation and air conditioning; lighting; machines; and all consumables and waste associated with treating ten patients with septic shock in the ICU at BarnesJewish Hospital, St. Louis, MO, United States (US-ICU) and ten patients at Footscray Hospital, Melbourne, Vic, Australia (Aus-ICU). MAIN OUTCOME MEASURES: Environmental footprint, particularly greenhouse gas emissions. RESULTS: Energy use per patient averaged 272 kWh/day for the US-ICU and 143 kWh/day for the Aus-ICU. The average daily amount of single-use materials per patient was 3.4 kg (range, 1.0-6.3 kg) for the US-ICU and 3.4 kg (range, 1.2-8.7 kg) for the Aus-ICU. The average daily particularly greenhouse gas emissions arising from treating patients in the US-ICU was 178 kg carbon dioxide equivalent (CO2-e) emissions (range, 165-228 kg CO2-e), while for the Aus-ICU the carbon footprint was 88 kg CO2-e (range, 77-107 kg CO2-e). Energy accounted for 155 kg CO2-e in the US-ICU (87%) and 67 kg CO2-e in the Aus-ICU (76%). The daily treatment of one patient with septic shock in the US-ICU was equivalent to the total daily carbon footprint of 3.5 Americans' CO2-e emissions, and for the Aus-ICU, it was equivalent to the emissions of 1.5 Australians. CONCLUSION: The carbon footprints of the ICUs were dominated by the energy use for heating, ventilation and air conditioning; consumables were relatively less important, with limited effect of intensity of patient care. There is large opportunity for reducing the ICUs' carbon footprint by improving the energy efficiency of buildings and increasing the use of renewable energy sources.
-
ItemA Novel Approach for 3D Modeling and Geovisualization of Easement Rights in Apartments(CMV Verlag, 2018-12-01)
-
ItemReduced oxidative capacity in macrophages results in systemic insulin resistance.(Springer Science and Business Media LLC, 2018-04-19)Oxidative functions of adipose tissue macrophages control the polarization of M1-like and M2-like phenotypes, but whether reduced macrophage oxidative function causes systemic insulin resistance in vivo is not clear. Here, we show that mice with reduced mitochondrial oxidative phosphorylation (OxPhos) due to myeloid-specific deletion of CR6-interacting factor 1 (Crif1), an essential mitoribosomal factor involved in biogenesis of OxPhos subunits, have M1-like polarization of macrophages and systemic insulin resistance with adipose inflammation. Macrophage GDF15 expression is reduced in mice with impaired oxidative function, but induced upon stimulation with rosiglitazone and IL-4. GDF15 upregulates the oxidative function of macrophages, leading to M2-like polarization, and reverses insulin resistance in ob/ob mice and HFD-fed mice with myeloid-specific deletion of Crif1. Thus, reduced macrophage oxidative function controls systemic insulin resistance and adipose inflammation, which can be reversed with GDF15 and leads to improved oxidative function of macrophages.
-
ItemComparisons of cancer-associated fibroblasts in the intratumoral stroma and invasive front in colorectal cancer.(Ovid Technologies (Wolters Kluwer Health), 2019-05)The aim of this study was to evaluate the cytomorphologic maturity and molecular activation of cancer-associated fibroblasts (CAFs) in the intratumoral stroma and invasive front in colorectal cancer and understand how they affect cancer invasion and long-term oncological outcomes.The cytomorphologic maturity of and α-smooth muscle actin (α-SMA), fibroblast activation protein α (FAPα), and fibroblast-specific protein 1 (FSP-1) expression in CAFs in the intratumoral stroma (CAF) and the invasive front (CAF) of colorectal cancer tissues were compared (n = 147). The correlations between CAF maturation, molecular activity markers, and cancer invasion were evaluated by network analysis. Overall survival and systemic recurrence were analyzed to assess the oncological effects of CAF properties.The cytomorphologic maturation rate was comparable between CAF and CAF. The presence of mature CAFs was related to epidermal growth factor receptor overexpression in cancer cells. Expression rates of α-SMA (96.6%-98.0%) and FAPα (18.6%-22.9%) were similar between CAF and CAF. FSP-1 expression was more frequent in CAF than in CAF (66.4% vs 58.2%, P = .038). There was a significant decrease in FSP-1 expression in CAF and CAF in higher stages. The infiltrating growth pattern of the tumor was more frequent in the immature CAF. In colorectal cancer with perineural invasion and lymph node metastasis, FSP-1 expression in CAF was significantly lower. On multivariate analysis using the Cox proportional hazards model, immature CAF was found to be an independent prognostic factor of overall survival. In non-metastatic (stage I-III) colorectal cancer patients, CAF maturity was not a prognostic factor for systemic recurrence.Cytomorphologic maturity and molecular activation markers were similar between CAFs in the intratumoral stroma and invasive front of colorectal cancer.
-
ItemCancer-Associated Fibroblasts and Desmoplastic Reactions Related to Cancer Invasiveness in Patients With Colorectal Cancer.(Korean Society of Coloproctology, 2019-02)PURPOSE: We evaluated the relationship of cancer-associated fibroblasts (CAFs) and desmoplastic reactions with cancer invasiveness and long-term outcomes in patients with colorectal cancer (CRC). METHODS: Histologic evaluation of mature CAFs and desmoplasia was performed by observing the collagen fiber structure and fibroblast cytomorphology in the intratumoral stroma and invasive front of CRC tissues. Cancer-cell invasiveness was evaluated using lymphatic invasion, vascular invasion, perineural invasion, tumor budding, and tumor growth patterns. Overall survival and systemic recurrence were analyzed. A network analysis was performed between CAF maturation, desmoplastic reaction, and cancer invasiveness. RESULTS: The proportions of mature CAFs in the intratumoral stroma and the invasive front were 57.6% and 60.3%, respectively. Epidermal growth factor receptor (EGFR) overexpression was significantly higher in the mature CAFs in the invasive front as compared to immature CAFs. Lymphatic invasion increased as the number of mature fibroblasts in the intratumoral stroma increased. Tumor budding was observed in almost half of both mature and immature stroma samples and occurred more frequently in infiltrating tumors. On network analysis, well-connected islands were identified that was associated with EGFR overexpression, CAF maturation, and infiltrating tumor growth patterns leading to tumor budding. CONCLUSION: The maturity of CAFs and desmoplastic reactions were associated with cancer invasion. However, the cytomorphologic characteristics of CAFs were insufficient as an independent prognostic factor for patients with CRC.
-
ItemKey factors influencing differences in stream water quality across space(WILEY, 2018-01-01)Globally, many rivers are experiencing declining water quality, for example, with altered levels of sediments, salts, and nutrients. Effective water quality management requires a sound understanding of how and why water quality differs across space, both within and between river catchments. Land cover, land use, land management, atmospheric deposition, geology and soil type, climate, topography, and catchment hydrology are the key features of a catchment that affect: (1) the amount of suspended sediment, nutrient, and salt concentrations in catchments (i.e., the source), (2) the mobilization ,and (3) the delivery of these constituents to receiving waters. There are, however, complexities in the relationship between landscape characteristics and stream water quality. The strength of this relationship can be influenced by the distance and spatial arrangement of constituent sources within the catchment, cross correlations between landscape characteristics, and seasonality. A knowledge gap that should be addressed in future studies is that of interactions and cross correlations between landscape characteristics. There is currently limited understanding of how the relationships between landscape characteristics and water quality responses can shift based on the other characteristics of the catchment. Understanding the many forces driving stream water quality and the complexities and interactions in these forces is necessary for the development of successful water quality management strategies. This knowledge could be used to develop predictive models, which would aid in forecasting of riverine water quality. WIREs Water 2018, 5:e1260. doi: 10.1002/wat2.1260 This article is categorized under: Science of Water > Hydrological Processes Science of Water > Water Quality
-
ItemAn evaluation of a methodology for seasonal soil water forecasting for Australian dry land cropping systems(ELSEVIER, 2018-05-01)Soil water is a critical resource in many rain-fed agricultural systems. Climate variability represents a significant risk in these systems, which has been addressed in the past through seasonal weather outlooks. This study undertakes a pilot assessment of the potential to extend seasonal weather outlooks to plant available soil water (PASW). We analyse 20 sites in the southeast Australian wheat belt using seasonal weather outlooks from the Predictive Ocean-Atmosphere Model for Australia (POAMA; (the operational seasonal model of the Australian Bureau of Meteorology), which were downscaled and used in conjunction with the Agricultural Production Simulator (APSIM). Hindcast rainfall, potential evapotranspiration (PET) and PASW outlooks were produced on a monthly basis for 33 years at a point scale. The outlooks were assessed using a range of ensemble verification tools. The results showed hit rates that outperformed climatology for rainfall and PET in the short-term (0–2 months), and for PASW with longer lead times (2–5 months). Continuous rank probability skill scores (CRPSS) were generally statistically worse than climatology for rainfall and PET and statistically better than climatology for PASW over 1–3 months. The influence of initial soil water is seasonally dependent, with longer dependence in low evapotranspiration periods. Improved weather model downscaling approaches would transition to climatology and could improve both weather and PASW outlooks. PASW outlooks were strongly reliant on initial conditions, indicating the importance of understanding current soil water status, which needs to be interpreted in a seasonal context as its influence varies over the year. Expanded operational soil water monitoring would be important if PASW outlooks are to become routine.
-
ItemPredicting groundwater recharge for varying land cover and climate conditions - a global meta-study(COPERNICUS GESELLSCHAFT MBH, 2018-05-07)Abstract. Groundwater recharge is one of the important factors determining the groundwater development potential of an area. Even though recharge plays a key role in controlling groundwater system dynamics, much uncertainty remains regarding the relationships between groundwater recharge and its governing factors at a large scale. Therefore, this study aims to identify the most influential factors of groundwater recharge, and to develop an empirical model to estimate diffuse rainfall recharge at a global scale. Recharge estimates reported in the literature from various parts of the world (715 sites) were compiled and used in model building and testing exercises. Unlike conventional recharge estimates from water balance, this study used a multimodel inference approach and information theory to explain the relationship between groundwater recharge and influential factors, and to predict groundwater recharge at 0.5∘ resolution. The results show that meteorological factors (precipitation and potential evapotranspiration) and vegetation factors (land use and land cover) had the most predictive power for recharge. According to the model, long-term global average annual recharge (1981–2014) was 134 mm yr−1 with a prediction error ranging from −8 to 10 mm yr−1 for 97.2 % of cases. The recharge estimates presented in this study are unique and more reliable than the existing global groundwater recharge estimates because of the extensive validation carried out using both independent local estimates collated from the literature and national statistics from the Food and Agriculture Organization (FAO). In a water-scarce future driven by increased anthropogenic development, the results from this study will aid in making informed decisions about groundwater potential at a large scale.
-
ItemJustin Costelloe: a champion of arid-zone water research(Springer Verlag, 2019-11-06)Justin Francis Costelloe (Fig. 1) was born in 1965. He grew up in the mining city of Bendigo (Victoria, Australia) before studying Earth Sciences at the University of Melbourne. He went on to work as an exploration geologist in the mining industry in the dryland regions of Australia and Chile. He developed a love of Australia’s desert landscapes and returned to undertake Masters and PhD studies on arid zone hydrology at the University of Melbourne, before continuing as a research fellow and senior research fellow leading arid zone research projects. Justin was a leader in research aimed at understanding surface water and groundwater in Australia’s arid zone and also made important interdisciplinary contributions linking the hydrology and ecology of the arid zone, with a focus on Australia’s iconic Channel Country and the Great Artesian Basin (GAB).
-
ItemIntegrated assessment of the use of recycled concrete aggregate replacing natural aggregate in structural concrete(Elsevier, 2018)The use of recycled concrete aggregate (RCA) replacing natural aggregate (NA) to produce concrete named as recycled aggregate concrete (RAC) has gained increased importance in the last few decades. Despite many visible advantages associated with the initiative, RAC is not manufactured at commercial scale to replace natural aggregate concrete (NAC) used as structural concrete in Australia presently. To identify whether the production of RAC should be favoured against NAC, an integrated assessment combining multiple criteria is essential as the previous research findings provide mixed outcomes on financial viability, product performance and environmental performance. This paper uses an integrated assessment methodology employing cost-benefit analysis (CBA) which combines the financial, direct and indirect environmental, social outcomes associated with the initiative to evaluate its suitability. By combining several qualitative and quantitative studies published by the author/s, an integral result to compare the use of RCA replacing NA in structural applications is conducted in this study. Net present value (NPV) to society associated with a unit volume of RAC is evaluated as a representative indicator to compare RAC against NAC in this paper. The results state that a unit volume of RAC results in a positive NPV of 4.2–6.0% of the price of NAC for 30% replacement (and 16.3–22.6% for 100%), prior to being used in a building r. Simulation of application of the RAC to two case study buildings indicate that the average price of concrete used in the buildings is decreased by 4.1–6.1%. The results indicate that, if the external benefit associated with the production of RAC is internalised and passed on to the purchaser of the product, production of RAC in structural buildings result in a positive NPV and saving of building material costs to the contractor.