Mechanical Engineering - Research Publications
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ItemFeasibility and performance analysis of hybrid ground source heat pump systems in fourteen cities(PERGAMON-ELSEVIER SCIENCE LTD, 2021-11-01)Ground source heat pump systems (GSHP) for residential building heating, cooling, and hot water are highly energy efficient but capital intensive when sized for peak demands. The use of supplemental sources of energy with GSHP systems enables improved life-cycle economics through the reduction in the size and cost of the GSHP components. This paper investigates the life-cycle economics of hybrid solar-assisted ground source heat pump systems (SAGSHP) using simulations validated from field data. The economics and optimal sizing of SAGSHP systems for heating dominant climates in four locations in Australia and ten locations elsewhere are evaluated in order to explore the suitability and relative merits of SAGSHP systems in a range of heating dominant climates. In locations having high or moderate levels of solar irradiation, high electricity prices, and high or moderate gas prices, SAGSHP systems are shown to have the lowest life cycle cost amongst alternatives, with predicted savings of up to 30%.
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ItemA Distributed Coordination Approach for the Charge and Discharge of Electric Vehicles in Unbalanced Distribution Grids(IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC, 2024-03)
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ItemClassification of antiseizure drugs in cultured neuronal networks using multielectrode arrays and unsupervised learning(WILEY, 2022-07)OBJECTIVE: Antiseizure drugs (ASDs) modulate synaptic and ion channel function to prevent abnormal hypersynchronous or excitatory activity arising in neuronal networks, but the relationship between ASDs with respect to their impact on network activity is poorly defined. In this study, we first investigated whether different ASD classes exert differential impact upon network activity, and we then sought to classify ASDs according to their impact on network activity. METHODS: We used multielectrode arrays (MEAs) to record the network activity of cultured cortical neurons after applying ASDs from two classes: sodium channel blockers (SCBs) and γ-aminobutyric acid type A receptor-positive allosteric modulators (GABA PAMs). A two-dimensional representation of changes in network features was then derived, and the ability of this low-dimensional representation to classify ASDs with different molecular targets was assessed. RESULTS: A two-dimensional representation of network features revealed a separation between the SCB and GABA PAM drug classes, and could classify several test compounds known to act through these molecular targets. Interestingly, several ASDs with novel targets, such as cannabidiol and retigabine, had closer similarity to the SCB class with respect to their impact upon network activity. SIGNIFICANCE: These results demonstrate that the molecular target of two common classes of ASDs is reflected through characteristic changes in network activity of cultured neurons. Furthermore, a low-dimensional representation of network features can be used to infer an ASDs molecular target. This approach may allow for drug screening to be performed based on features extracted from MEA recordings.
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ItemNo Preview AvailableMulti-resolution, multi-horizon distributed solar PV power forecasting with forecast combinations(PERGAMON-ELSEVIER SCIENCE LTD, 2022-11-01)
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ItemNo Preview AvailableDimensionality reduction for visualizing high-dimensional biological data(ELSEVIER SCI LTD, 2022-10)High throughput technologies used in experimental biological sciences produce data with a vast number of variables at a rapid pace, making large volumes of high-dimensional data available. The exploratory analysis of such high-dimensional data can be aided by human interpretable low-dimensional visualizations. This work investigates how both discrete and continuous structures in biological data can be captured using the recently proposed dimensionality reduction method SONG, and compares the results with commonly used methods UMAP and PHATE. Using simulated and real-world datasets, we observe that SONG produces insightful visualizations by preserving various patterns, including discrete clusters, continuums, and branching structures in all considered datasets. More importantly, for datasets containing both discrete and continuous structures, SONG performs better at preserving both the structures compared to UMAP and PHATE. Furthermore, our quantitative evaluation of the three methods using downstream analysis validates the on par quality of the SONG's low-dimensional embeddings compared to the other methods.
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ItemA machine learning accelerated inverse design of underwater acoustic polyurethane coatings(SPRINGER, 2022-08)Abstract Here we propose a detailed protocol to enable an accelerated inverse design of acoustic coatings for underwater sound attenuation application by coupling Machine Learning and an optimization algorithm with Finite Element Models (FEM). The FEMs were developed to obtain the realistic performance of the polyurethane (PU) acoustic coatings with embedded cylindrical voids. The frequency dependent viscoelasticity of PU matrix is considered in FEM models to substantiate the impact on absorption peak associated with the embedded cylinders at low frequencies. This has been often ignored in previous studies of underwater acoustic coatings, where usually a constant frequency-independent complex modulus was used for the polymer matrix. The key highlight of the proposed optimization framework for the inverse design lies in its potential to tackle the computational hurdles of the FEM when calculating the true objective function. This is done by replacing the FEM with an efficiently computable surrogate model developed through a Deep Neural Network. This enhances the speed of predicting the absorption coefficient by a factor of $$4.5 \times 10^3$$ 4.5 × 10 3 compared to FEM model and is capable of rapidly providing a well-performing, sub-optimal solution in an efficient way. A significant, broadband, low-frequency attenuation is achieved by optimally configuring the layers of cylindrical voids. This is accomplished by accommodating attenuation mechanisms, including Fabry–P$$\acute{e}$$ e ´ rot resonance and Bragg scattering of the layers of voids. Furthermore, the proposed protocol enables the inverse and targeted design of underwater acoustic coatings through accelerating the exploration of the vast design space compared to time-consuming and resource-intensive conventional trial-and-error forward approaches.
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ItemIMPARO: inferring microbial interactions through parameter optimisation(BMC, 2020-08-19)BACKGROUND: Microbial Interaction Networks (MINs) provide important information for understanding bacterial communities. MINs can be inferred by examining microbial abundance profiles. Abundance profiles are often interpreted with the Lotka Volterra model in research. However existing research fails to consider a biologically meaningful underlying mathematical model for MINs or to address the possibility of multiple solutions. RESULTS: In this paper we present IMPARO, a method for inferring microbial interactions through parameter optimisation. We use biologically meaningful models for both the abundance profile, as well as the MIN. We show how multiple MINs could be inferred with similar reconstructed abundance profile accuracy, and argue that a unique solution is not always satisfactory. Using our method, we successfully inferred clear interactions in the gut microbiome which have been previously observed in in-vitro experiments. CONCLUSIONS: IMPARO was used to successfully infer microbial interactions in human microbiome samples as well as in a varied set of simulated data. The work also highlights the importance of considering multiple solutions for MINs.
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ItemExtremum Seeking Control with Sporadic Packet Transmission for Networked Control Systems(IEEE, 2020-06)Extremum Seeking Control (ESC) is a data-driven optimization technique that can steer a dynamic plant towards an extremum of an unknown but measurable, input to steady-state map. In the context of Networked Control Systems (NCS) a new implementation method for ESC inspired by the well known Luus-Jaakola algorithm is proposed. The main motivation is to minimize the communication burden associated with the search phase of ESC. In the proposed method the controller only requires a notification of a change registered at the sensor, rather than the full information available at the sensor. This event based approach leads to sporadic packet transmission. In addition the proposed method is able to directly account for constraints whilst seeking for the desired extremum. The constraints may be of the inequality or equality type. The algorithm's behavior is illustrated on a networked water pump control system.
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ItemDiscovering the pharmacodynamics of conolidine and cannabidiol using a cultured neuronal network based workflow(NATURE PORTFOLIO, 2019-01-15)Determining the mechanism of action (MOA) of novel or naturally occurring compounds mostly relies on assays tailored for individual target proteins. Here we explore an alternative approach based on pattern matching response profiles obtained using cultured neuronal networks. Conolidine and cannabidiol are plant-derivatives with known antinociceptive activity but unknown MOA. Application of conolidine/cannabidiol to cultured neuronal networks altered network firing in a highly reproducible manner and created similar impact on network properties suggesting engagement with a common biological target. We used principal component analysis (PCA) and multi-dimensional scaling (MDS) to compare network activity profiles of conolidine/cannabidiol to a series of well-studied compounds with known MOA. Network activity profiles evoked by conolidine and cannabidiol closely matched that of ω-conotoxin CVIE, a potent and selective Cav2.2 calcium channel blocker with proposed antinociceptive action suggesting that they too would block this channel. To verify this, Cav2.2 channels were heterologously expressed, recorded with whole-cell patch clamp and conolidine/cannabidiol was applied. Remarkably, conolidine and cannabidiol both inhibited Cav2.2, providing a glimpse into the MOA that could underlie their antinociceptive action. These data highlight the utility of cultured neuronal network-based workflows to efficiently identify MOA of drugs in a highly scalable assay.