Optometry and Vision Sciences - Theses

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2012 - 2016 3
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End date: 2017 × Start date: 2012 × Type: PhD thesis × Subject: retina ×

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    Age-related changes in structure, function and response to stress in the rat retina
    Paul, Joseph ( 2016)
    Ageing is a key risk factor for ocular diseases, though age-related changes in the eye have not been fully characterised. This study investigated age-related changes in retinal function, structure and their response to acute and chronic stress in Long Evans rats. With age, both retinal structure and function decline and the retina loses its ability to cope with acute stress. When exposed to mild chronic stress, older eyes suffered greater functional damage than younger eyes.
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    Functional correlates between the rat electroretinogram and visual evoked potential
    Tsai, Tina I-ting ( 2012)
    The ERG and VEP are sequentially-activated responses, widely used for diagnosis of eye and brain diseases. Measuring both simultaneously provides additional information to help localise where in the visual pathway injury has occurred. This thesis shows how retinal information streams are encoded in the VEP. In addition, it shows that changes to ERG components can predict the amount of loss downstream in the retina. However, retinal loss may not predict VEP changes.
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    Susceptibility of the diabetic rat retina to intraocular pressure challenge
    Wong, Vickie Hoi Ying ( 2012)
    This thesis shows that hyperglycaemia makes retinal function and ocular blood flow more sensitive to acute intraocular pressure (IOP) elevation. Increased functional susceptibility was associated with a reduced capacity to upregulate endothelial nitric oxide synthase. Chronic IOP elevation (4 weeks) produced retinal dysfunction and exacerbated the susceptibility of ocular blood flow to IOP challenge in diabetic but not healthy rats. These data suggest that hyperglycaemia-induced blood flow anomalies may contribute to the functional susceptibility of the diabetic eye to IOP.