Optometry and Vision Sciences

Search Results

Now showing 1 - 2 of 2

Ageing effects on ocular blood flow, oxygen tension and function during IOP elevation

Lim, Jeremiah Kah Heng ( 2012)

This is the first study to simultaneously measure electroretinography, ocular blood flow, and oxygen tension during intraocular pressure elevation. By doing so it shows that changes in oxygen tension are more closely related to function than blood flow. Moreover, by comparing these parameters in young and older eyes this study shows that older eyes have less oxygen availability with higher intraocular pressure despite having similar function. This argues that older eyes use more oxygen to sustain normal function.
Time course of retinal changes in models of chronic IOP elevation

Hui, Flora ( 2010)

Glaucoma is an increasingly common sight threatening disease. Our understanding of the pathogenesis requires good models for disease risk factors. This thesis refines models of chronic intraocular pressure elevation in rats. Non-invasive assessment showed evidence of widespread retinal dysfunction. It is clear that dysfunction was not solely determined by intraocular pressure, but is associated with either ocular trauma or agent toxicity. Clear methodological recommendations are provided to minimise widespread damage and thus provide improved models for understanding glaucoma.