Optometry and Vision Sciences - Theses

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Subject: electroretinography × Subject: glaucoma × Subject: retina ×

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    Age-related changes in structure, function and response to stress in the rat retina
    Paul, Joseph ( 2016)
    Ageing is a key risk factor for ocular diseases, though age-related changes in the eye have not been fully characterised. This study investigated age-related changes in retinal function, structure and their response to acute and chronic stress in Long Evans rats. With age, both retinal structure and function decline and the retina loses its ability to cope with acute stress. When exposed to mild chronic stress, older eyes suffered greater functional damage than younger eyes.
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    Ageing effects on ocular blood flow, oxygen tension and function during IOP elevation
    Lim, Jeremiah Kah Heng ( 2012)
    This is the first study to simultaneously measure electroretinography, ocular blood flow, and oxygen tension during intraocular pressure elevation. By doing so it shows that changes in oxygen tension are more closely related to function than blood flow. Moreover, by comparing these parameters in young and older eyes this study shows that older eyes have less oxygen availability with higher intraocular pressure despite having similar function. This argues that older eyes use more oxygen to sustain normal function.