Optometry and Vision Sciences - Theses

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Type: PhD thesis × Subject: retina × Subject: electroretinography × Start date: 2016 × End date: 2019 ×

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    Characterising the ocular phenotype in a murine model of Alzheimer’s disease
    Lim, Jeremiah ( 2018)
    This thesis shows that amyloid beta found in the brain is also present in the retina of a murine model of Alzheimer’s disease. By applying non-invasive retinal techniques, we show that neuronal structural and functional changes occur early in this model and that these are associated with vascular dysfunction. Such retinal hallmarks differentiate Alzheimer's changes from healthy ageing mice and provide evidence that the retina is a viable biomarker for dementia.
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    Age-related changes in structure, function and response to stress in the rat retina
    Paul, Joseph ( 2016)
    Ageing is a key risk factor for ocular diseases, though age-related changes in the eye have not been fully characterised. This study investigated age-related changes in retinal function, structure and their response to acute and chronic stress in Long Evans rats. With age, both retinal structure and function decline and the retina loses its ability to cope with acute stress. When exposed to mild chronic stress, older eyes suffered greater functional damage than younger eyes.