Optometry and Vision Sciences - Theses

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Subject: retina × Subject: electrophysiology ×

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    Ageing effects on ocular blood flow, oxygen tension and function during IOP elevation
    Lim, Jeremiah Kah Heng ( 2012)
    This is the first study to simultaneously measure electroretinography, ocular blood flow, and oxygen tension during intraocular pressure elevation. By doing so it shows that changes in oxygen tension are more closely related to function than blood flow. Moreover, by comparing these parameters in young and older eyes this study shows that older eyes have less oxygen availability with higher intraocular pressure despite having similar function. This argues that older eyes use more oxygen to sustain normal function.
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    Functional correlates between the rat electroretinogram and visual evoked potential
    Tsai, Tina I-ting ( 2012)
    The ERG and VEP are sequentially-activated responses, widely used for diagnosis of eye and brain diseases. Measuring both simultaneously provides additional information to help localise where in the visual pathway injury has occurred. This thesis shows how retinal information streams are encoded in the VEP. In addition, it shows that changes to ERG components can predict the amount of loss downstream in the retina. However, retinal loss may not predict VEP changes.
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    Susceptibility of the diabetic rat retina to intraocular pressure challenge
    Wong, Vickie Hoi Ying ( 2012)
    This thesis shows that hyperglycaemia makes retinal function and ocular blood flow more sensitive to acute intraocular pressure (IOP) elevation. Increased functional susceptibility was associated with a reduced capacity to upregulate endothelial nitric oxide synthase. Chronic IOP elevation (4 weeks) produced retinal dysfunction and exacerbated the susceptibility of ocular blood flow to IOP challenge in diabetic but not healthy rats. These data suggest that hyperglycaemia-induced blood flow anomalies may contribute to the functional susceptibility of the diabetic eye to IOP.