School of Chemistry - Research Publications

Permanent URI for this collection

http://hdl.handle.net/11343/300

Filters

2012 - 2014 3
Reset filters

Settings
Statistics
Citations
Author: BEST, JAMES × Author: JOHNSTON, ANGUS × Author: Such, Georgina × Type: Journal Article ×

Search Results

Now showing 1 - 3 of 3
  • Item
    Thumbnail Image
    Engineering Particles for Therapeutic Delivery: Prospects and Challenges
    Yan, Y ; Such, GK ; Johnston, APR ; Best, JP ; Caruso, F (AMER CHEMICAL SOC, 2012-05)
    Nanoengineered particles that can facilitate drug formulation and passively target tumors have reached the clinic in recent years. These early successes have driven a new wave of significant innovation in the generation of advanced particles. Recent developments in enabling technologies and chemistries have led to control over key particle properties, including surface functionality, size, shape, and rigidity. Combining these advances with the rapid developments in the discovery of many disease-related characteristics now offers new opportunities for improving particle specificity for targeted therapy. In this Perspective, we summarize recent progress in particle-based therapeutic delivery and discuss important concepts in particle design and biological barriers for developing the next generation of particles.
  • Item
    Thumbnail Image
    Mechanically Tunable, Self-Adjuvanting Nanoengineered Polypeptide Particles
    Cui, J ; De Rose, R ; Best, JP ; Johnston, APR ; Alcantara, S ; Liang, K ; Such, GK ; Kent, SJ ; Caruso, F (WILEY-V C H VERLAG GMBH, 2013-07-05)
    DNA-loaded polypeptide particles are prepared via templated assembly of mesoporous silica for the delivery of adjuvants. The elasticity and cargo-loading capacity of the obtained particles can be tuned by the amount of cross-linker used to stabilize the polypeptide particles. The use of polypeptide particles as biocarriers provides a promising method for vaccine delivery.
  • Item
    Thumbnail Image
    Fundamental Studies of Hybrid Poly(2-(diisopropylamino)ethyl methacrylate)/Poly(N-vinylpyrrolidone) Films and Capsules
    Ng, SL ; Best, JP ; Kempe, K ; Liang, K ; Johnston, APR ; Such, GK ; Caruso, F (AMER CHEMICAL SOC, 2014-07)
    Hybrid and multicompartment carriers are of significant interest for the development of next-generation therapeutic drug carriers. Herein, fundamental investigations on layer-by-layer (LbL) capsules consisting of two different polymers are presented. The hybrid systems were designed to have pH-responsive, charge-shifting poly(2-(diisopropylamino)ethyl methacrylate) (PDPA) inner layers and low-fouling poly(N-vinylpyrrolidone) (PVPON) outer layers. Planar hybrid films with different layer ratios were studied by quartz crystal microgravimetry (QCM) and atomic force microscopy (AFM). The information obtained was translated to particulate templates to prepare hybrid capsules, which were stabilized by click chemistry. The charge-shifting behavior of PDPA improved the cargo encapsulation and initial retention of a model CpG cargo, while outer layers of PVPON improved biofouling properties compared to single-component PDPA capsules. The results demonstrate the need to understand and design multifunctional systems that can successfully embody different functionalities in a single, stable construct for the fabrication of next-generation drug and gene delivery carriers aimed at overcoming the challenges encountered in biological systems.